“How likely you are to develop osteoporosis ? — a condition that causes bones to become weak and brittle — depends on how much bone mass you attain by the time you reach age 30 and how rapidly you lose it after that.”

MAYO CLINIC

Is life worth living?   It all depends on the liver.

       NASH LIVER                           DISEASED LIVER          FATTY TISSUE LIVER

Liver Disease is also referred to Hepatic Disease. Liver Disease is a term that is used when there is any disturbance of the liver function that causes illness. It is a broad term to describe when more than 75% or three quarters of liver tissue needed is affected and decreased function in the liver occurs. The number one cause of liver disease is alcohol abuse in North America. They can cause liver inflammation, referred to as alcoholic hepatitis. Other causes include Cirrhosis, Cholestasis, Steatosis, Hepatitis, Viruses, Non-Alcoholic Fatty Liver, Hemachromatosis, Wilson’s Disease and Gilbert’s Disease.

Causes: Cirrhosis

Cirrhosis is when the liver cells are replaced by permanent scar tissue as a result of chronic liver disease. It is considered the late-stage of liver disease. Cirrhosis is common among chronic alcohol abuse users where the fat accumulation occurs in the liver cells and causes scar tissue. Cholestasis is when the bile flow is obstructed from the gallbladder or duodenum. Steatosis is the term used when cholesterol and triglycerides accumulate in the liver.

Causes: Hepatitis

Hepatitis is a term used to describe the inflammation on liver cells. They can become inflamed due to infection.

There are many forms of Hepatitis:

Hepatitis A (Hep A) is a viral infection primarily spread through the fecal-oral route when small amounts of infected fecal matter are ingested. An acute inflammation of the liver occurs but there is a way to prevent this type of infection. There is a vaccine available and the best way to help prevent it is by a good hand washing.

Hepatitis B (Hep B) is spread by exposure to body fluids and can cause an acute infection. If left untreated, it can progress into a chronic inflammation and on into cirrhosis. There is also a vaccine for this form of hepatitis. Typically, the vaccine contains both Hep A and B in a combination series of doses.

Hepatitis C (Hep C) is caused by a virus different from Hep A or Hep B. It can either be “acute” or “chronic” and is primarily spread through contact with the blood of an infected person. The most common way is by sharing needles or other equipment to inject drugs. Before 1992, Hepatitis C was also commonly spread through blood transfusions and organ transplants which led to the start of a widespread screening of blood supplies. Another way it can be transmitted is through being born to a mother who has it. There are less common ways to contract Hepatitis C, and that’s through sharing personal care items that may have come into contact with another person’s blood (razors, toothbrushes), or having unprotected sex with a infected person. Some people are at an increased risk for Hepatitis C. Those individuals include: Children born to mothers infected with this Hep C; current injection drug users (most common way Hepatitis C is spread in the US), past injection drug users, recipients of donated blood (blood products and organs), hemodialysis patients who spent many years on dialysis for kidney failure, people who received body piercings or tattoos done with non-sterile instruments, & people with known exposure to Hepatitis C like Health care workers or recipients of blood or organs from a donor who tested positive.

Hepatitis D (Hep D) is known as “delta hepatitis” can also be “acute” or “chronic” but is uncommon in the United States. It requires the Hepatitis B virus to survive. It is transmitted through sexual contact with infected blood or blood products. There is also no vaccine available for this virus. Hepatitis E (Hep E) is caused by Ribonucleic Acid (RNA) virus. It is transmitted mainly through the fecal-oral route due to fecal contaminated drinking water.

Causes: NAFLD

Non-alcoholic fatty liver disease (NAFLD) is the build up of extra fat in liver cells that is not caused by alcohol. It is normal for the liver to contain some fat. liver’s weight is fat, then it NAFLD tends to develop in people who are overweight or obese or have diabetes, high cholesterol or high triglycerides. Rapid weight loss and poor eating habits also may lead to NAFLD. However, some people develop NAFLD even if they do not have any risk factors. NAFLD affects up to 25% of people in the United States. However, if more than 5% up to 10% of the liver’s weight is fat then the liver is called a fatty liver called steatosis.  Non-Alcoholic Fatty Liver (NAFL) describes the accumulation of fat within the liver that can cause an inflammation and a gradual decrease in function.

  Causes: NAFLD

 Those at risk for NAFLD? NAFLD tends to develop in people who are overweight or obese or have diabetes, high cholesterol or high triglycerides. Rapid weight loss and poor eating habits also may lead to NAFLD. However, some people develop NAFLD even if they do not have any risk factors. NAFLD affects up to 25% of people in the United States.

RISKS NAFLD may cause the liver to swell (steatohepatitis). A swollen liver may cause scarring (cirrhosis) over time and may even lead to liver cancer or liver failure.

SYMPTOMS NAFLD often has no symptoms. When symptoms occur, they may include fatigue, weakness, weight loss, loss of appetite, nausea, abdominal pain, spider-like blood vessels, yellowing of the skin and eyes (jaundice), itching, fluid build up and swelling of the legs (edema) and abdomen (ascites), and mental confusion.

DIAGNOSIS NAFLD is initially suspected if blood tests show high levels of liver enzymes. However, other liver diseases are first ruled out through additional tests. Often, an ultrasound is used to confirm the NAFLD diagnosis.

TREATMENT There are no medical treatments yet for NAFLD. Eating a healthy diet and exercising regularly may help prevent liver damage from starting or reverse it in the early stages.

• See a doctor who specializes in the liver regularly
• Talk to your doctor about ways to improve your liver health
• Lose weight, if you are overweight or obese
• Lower your cholesterol and triglycerides
• Control your diabetes
• Avoid alcohol
• *
• PREVENTION There are ways to prevent NAFLD:
• Maintain a healthy weight
• Eat a healthy diet
• Exercise regularly
• Limit alcohol intak
• Only take medicines that you need and follow dosing recommendations. The more severe form of NAFLD is called non-alcoholic steatohepatitis (NASH). NASH causes the liver to swell and become damaged. NASH tends to develop in people who are overweight or obese, or have diabetes, high cholesterol or high triglycerides. NASH can occur in many.
• *
•  Causes: NASH:Nonalcoholic steatohepatitis or NASH is a common, often “silent” liver disease. It resembles alcoholic liver disease, but occurs in people who drink little or no alcohol. The major feature in NASH is fat in the liver, along with inflammation and damage. Most people with NASH feel well and are not aware that they have a liver problem. Nevertheless, NASH can be severe and can lead to cirrhosis, in which the liver is permanently damaged and scarred and no longer able to work properly.NASH affects 2 to 5 percent of Americans. An additional 10 to 20 percent of Americans have fat in their liver, but no inflammation or liver damage, a condition called “fatty liver.” Although having fat in the liver is not normal, by itself it probably causes little harm or permanent damage. If fat is suspected based on blood test results or scans of the liver, this problem is called nonalcoholic fatty liver disease (NAFLD). If a liver biopsy is performed in this case, it will show that some people have NASH while others have simple fatty liver.
• Most people with NASH are between the ages of 40 and 60 years. It is more common in women than in men. NASH often has no symptoms and people can have NASH for years before symptoms occur. NASH is one of the leading causes of cirrhosis in the United States.  Up to 25% of adults with NASH may have cirrhosis.  Know people have NASH even if they do not have one risk factor can get the disease.
• Both NASH and NAFLD are becoming more common, possibly because of the greater number of Americans with obesity. In the past 10 years, the rate of obesity has doubled in adults and tripled in children. Obesity also contributes to diabetes and high blood cholesterol, which can further complicate the health of someone with NASH. Diabetes and high blood cholesterol are also becoming more common among Americans.
• • Nonalcoholic steatohepatitis (NASH) is fat in the liver, with inflammation and damage.
  • NASH occurs in people who drink little or no alcohol and affects 2 to 5 percent of Americans, especially people who are middle-aged and overweight or obese.
  • NASH can occur in children.
  • People who have NASH may feel well and may not know that they have a liver disease.
  • NASH can lead to cirrhosis, a condition in which the liver is permanently damaged and cannot work properly.
  • Fatigue can occur at any stage of NASH.
  • Weight loss and weakness may begin once the disease is advanced or cirrhosis is present.
  • NASH may be suspected if blood tests show high levels of liver enzymes or if scans show fatty liver.
  • NASH is diagnosed by examining a small piece of the liver taken through a needle, a procedure called biopsy.
  • People who have NASH should reduce their weight, eat a balanced diet, engage in physical activity, and avoid alcohol and unnecessary medications.
  • No specific therapies for NASH exist. Experimental therapies being studied include antioxidants and antidiabetes medications.

Other Pointers in knowing about the types of liver diseases:

• Most liver diseases are managed and not cured. The exception is for gallstone disease and some viral infections like Hepatitis A and infectious mononucleosis. All forms of liver disease has the ability to progress to cirrhosis and cause liver failure. Complications associated with cirrhosis and liver failure include an increased risk of bleeding and infection, malnutrition and weight loss, and decreased cognitive function.
• Depending on the type of cause for liver disease, determines how it is treated. Hep A requires supportive care from others to maintain hydration while the body’s immune system continues to fight off infections. Other diseases may require long-term care to control and minimize consequences of a particular disease. With cirrhosis and end-stage liver disease patients, they are often given medications to control the amount of protein absorbed in the diet. For other cirrhosis patients, they may not be able to metabolize waste products which raises their blood ammonia levels. To help them function, they need to take water pills (diuretics) and start a low sodium diet to minimize water retention. Only when all other options have failed is liver transplantation an option.
• Symptoms of liver disease range depending on the exact cause for the limited liver function. The general symptoms include a weakness or fatigue, weight loss, nausea, vomiting, fever and a yellow discoloration. If these symptoms are experienced without an explanation, it may be time to consult a medical professional. The time for education is before something like this happens. The survival rate is much higher for the individuals that seek medical attention early on through the act of having the knowledge to make the right decision. By the way the yellow discoloration is what we call Jaundice.
• Some of the other viruses that cause liver disease are viral infections like Mononucleosis, Adenovirus and Cytomegalovirus. There are also non-viral infections like toxoplasmosis and Rocky Mountain Spotted fever that could lead to liver disease but they are less common.
• There are other conditions like Hemachromatosis (iron overload), which is a metabolic disorder that leads to abnormally elevated amounts of iron that is stored in the body. It is an inherited disease. Wilson’s disease is another inherited disease but it affects the body’s ability to metabolize copper. Gilbert’s Disease is an abnormality in bilirubin metabolism in the liver and affects up to 7% of the North American population.
• Most people with NASH are between the ages of 40 and 60 years. It is more common in women than in men. NASH often has no symptoms and people can have NASH for years before symptoms occur. NASH is one of the leading causes of cirrhosis in adults in the United States. Up to 25% of adults with NASH may have cirrhosis. Know people have NASH even if they do not have one risk factor.

Due to alcohol abuse acting as the most common cause of liver disease, it is recommended that alcohol consumption is in moderation. It may help minimize the risk of alcohol-related liver disease. Hepatitis B and C contraction can be decreased by minimizing the risk of exposure to another person’s bodily fluids. There is a vaccination available for Hepatitis A and B. There is screening available for Hepatitis C at most clinics or doctors offices. Fatty liver disease is preventable by the promotion of a healthy lifestyle. Those lifestyle choices include a well-balanced diet, weight control, avoiding excess alcohol consumption and routine exercise.

“If you are drinking more than you should,  one herbal supplement to try is milk thistle.  This helps the liver do its job of detoxifying the body.”

Kate Cook (born 24 April 1962, Nutrition and Wellness expert, author and keynote speaker).

“I always work out because I have scoliosis  I have to maintain strength in my core.”

Joan Smalls Rodriguez, (born July 11, 1988 is a fashion model. In 2013, she ranked at #8 on Forbes magazine’s “World’s Highest-Paid Models” list.

“Everyone is has sarcoidosis is affected differently.”

Duffy was leading a relatively carefree youth in her young days and of her modeling career when in 1995 she was diagnosed with the relatively rare disease sarcoidosis. In her case, this affected her brain (neurosarcoidosis), leaving her partially paralyzed.

Go to striveforgoodhealth.com and learn about sarcoidosis and the different areas it can affect.

AMYLOIDOSIS

What is Amyloidosis?  Amyloidosis (am-uh-loi-DO-sis) is a rare disease that occurs when a substance called amyloid builds up in your organs. Amyloid is an abnormal protein that is usually produced in your bone marrow and can be deposited in any tissue or organ.

The cause of primary amyloidosis is unknown. The condition is related to abnormal and excess production of antibodies by a type of immune cell called plasma cells. Clumps of abnormal proteins build up in certain organs. This reduces their ability to work correctly.

Symptoms depend on the organs affected.  Amyloidosis frequently affects the heart, kidneys, liver, spleen, nervous system and digestive tract. Severe amyloidosis can lead to life-threatening organ failure. This disease can affect the tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys.  Skin changes, such as thickening or easy bruising, and purplish patches around the eyes, difficulty swallowing,

Symptoms include: enlarged tongue, difficulty swallowing, feeling full quickly when eating, and significant weight loss, diarrhea possibly with blood or constipation, abnormal heart rhythm, fatigue, numbness of hands or feet, shortness of breath, hoarseness or changing voice, swelling of your ankles and legs and joint pain.

Amyloid is produced in your bone marrow and can be deposited in any tissue or organ affecting the tissue and organs like stated previously. The specific cause of this condition depends on the type of amyloidosis present.

Unfortunately, there are many different types of amyloidosis.  Here are the types:

– Immunoglobulin light chain (AL) amyloidosis.  This is the most common type, can affect your heart, kidneys, skin, nerves and liver. It was previously known as primary amyloidosis. It occurs when your bone marrow produces abnormal antibodies that can’t be broken down. The antibodies are deposited in your tissues as amyloid, interfering with normal function.   Most people diagnosed with AL amyloidosis, the most common type, are age 50 or older, although earlier onset can occur.  This is  hard in preventing this disease from occurring.  Nearly 70 percent of people with AL amyloidosis are men.

– AA amyloidosis, mostly affects your kidneys but occasionally your digestive tract, liver or heart. It was previously known as secondary amyloidosis. It occurs along with chronic infectious or inflammatory diseases, such as rheumatoid arthritis or inflammatory bowel disease.  One way to prevent this is through good health to prevent chronic infections, possibly rheumatoid arthritis or inflammatory bowel disease.

– Hereditary (familial) amyloidosis, is an inherited disorder that often affects the liver, nerves, heart and kidneys. One type is caused by a certain amyloid (transthyretin amyloid) that can affect the nervous system or the heart.  This is hereditary and unlikely to prevent but see your MD regularly to be checked for it every 6 months or yearly.  See what your MD suggests if you know this is in your family. African-Americans have a greater risk of this type than do Caucasians. It is thought to be a significant cause of heart failure in African-American men.

– Dialysis-related amyloidosis, develops when proteins in blood are deposited in joints and tendons which end up causing pain, stiffness and fluid in the joints, as well as carpal tunnel syndrome. This type generally affects people on long-term dialysis.  Dialysis can’t always remove large proteins from the blood. If you’re on dialysis, abnormal proteins can build up in your blood and eventually be deposited in tissue. The good news regarding this type of amyloidosis is this condition is less common with modern dialysis techniques.

IN THE END WHAT THIS CONDITION LEAVES AS AN END RESULT TO INTEFERE WITH NORMAL FUNCTION OF TISSUES/ORGANS IN THE HUMAN BODY:

1.) Amyloid can harm the kidneys’ filtering system=our toileting system of the human body which takes toxics out of the bloodstream dumping them into the urinary bladder that our body voids out of the body through urinating.  If this organ, the kidneys are affected, this ends up causing protein to leak from your blood into your urine. The kidneys’ ability to remove waste products from your body is lowered, which may eventually lead to kidney failure (if 100% failure occurs now hemodialysis starts causing the amyloidosis to be at risk for just getting worse, see above dialysis-related amyloidosis).

2.) Amyloid can harm the nervous system, which affects our electrical system of the human body.  You may experience pain, numbness or tingling of the fingers or numbness, lack of feeling or a burning sensation in your toes or the soles of your feet. If amyloid affects the nerves that control your bowel function, you may experience periods of alternating constipation and diarrhea. Sometimes amyloidosis affects nerves that control blood pressure, and you may experience dizziness or near fainting when standing too quickly, as a result of a drop in your blood pressure due to orthostatic hypotension occurring secondary to the nerves affecting the B/P.

3.) Amyloid if it affects the engine of the human body it will cause reduction of that organ’s function being the heart.  It causes your heart’s ability to fill with blood between heartbeats. Less blood is filled up in each chamber of the heart at the normal level an this causes the heart to pump out less cardiac output with each beat, especially the left ventricle of the heart that pumps out oxygenated blood throughout the body.  This causes less oxygenated blood to our tissues and like plumbing when the pipes (in this case the arteries with veins) cause back up in the running of blood which go back to the lungs first (does not take long) all the way down to the feet (this takes time).  This in the end can make you experience shortness of breath due to fluid build up in the lungs. If amyloidosis affects your heart’s electrical system, your heart rhythm may be disturbed.  This can put you into arrhythmias the longer you don’t take care of the situation the worse the rhythm will get.

You may go to your general practitioner first depending on your insurance coverage but if it is questionable or your GP thinks it amyloidosis you should be referred to a doctor who specializes in blood disorders (hematologist).  Be prepared with questions already written out at home when you see your doctor so you don’t walk out of the office knocking your head saying “I forgot to ask him…”.   That could be from signs and symptoms, causes, risk factors, tests, treatments/medications, etc…

There’s no cure unfortunately for amyloidosis. But treatments can help you manage your symptoms and limit the production of amyloid protein.

Diagnosis and Tests for Amyloidosis:

*1. First your doctor would do a thorough medical exam with blood/urine tests searching for clues of high protein where it shouldn’t belong or certain liver or thyroid abnormal findings. The MD will follow with further diagnostic tooling especially if these findings show up in blood/urine tests. Common blood exams used are BNP (basic natriuretic peptide). BNP is a substance secreted from the ventricles or lower chambers of the heart in response to stress and changes in pressure that occur when to heart failure develops and worsens. The level of BNP in the blood increases when heart failure symptoms worsen, and decreases when heart failure condition is stable. It is not so much elevated over the norm but more with this disease patients the MD will see where the BNP level was at last visit & compare.

Another blood test is troponin and this gets released into the bloodstream when your heart is affected by amyloids.

*2. Second your MD may want to further diagnose for this disease through getting a tissue biopsy where the MD’s intent is to check for signs indicating this is highly possible for amyloidosis. The biopsy could be taken from your abdominal fat, bone marrow, or an organ such as your liver or kidney. Tissue analysis can help determine the type of amyloid deposit.

*3. Imaging Tests. Images taken of the organs that are affected by amloidosis can help the MD establish the intensity or stage your disease is at. There are 2 most commonly imaging tests used and can diagnose the disease early. There is the echocardiogram test, sound wave imaging of the heart, that will be used to assess the size and functioning capability level of the heart. Another test is a MRI of the heart (magnetic residence imaging). Other imaging tests can evaluate the extent of amyloidosis in the liver or spleen.

When the heart chambers become filled with amyloids it thickens the walls of those chambers especially the lower chambers which can be picked up by the echocardiogram through the different angles of sound waves that go via the heart during this exam. Another thing that can be measured through the echocardiogram is your diagnostic function; that represents a measure of how stiff your heart is and how well is your heart actually functioning.

Another technique that can be used is strain imaging. This is also done through echocardiogram. This tells the doctor in more detail how much the muscle fibers in the heart are actually shortening and contracting. It measures certain parts of the heart in actually contracting and function. This is actually better in help diagnosing compared to just looking at ejection fraction, which is the amount of blood pumped out of the left ventricle chamber upon contraction of the heart (When he hear lub dub of the heart with a stethoscope that is the heart actually contracting. First the upper chamber on lub is contracting and on dub is the lower chambers contracting). This test is a specializing test and is not widely used but it is available in certain hospitals.

Ending line amyloidosis is a group of diseases in which one or more organ systems in the body accumulate abnormal proteins known as amyloid. The name amyloidosis was first used more than 150 years ago, but cases were described over 300 years ago. However, only in the past ¼ of a century have MD’s understood the specific make up and structure of amyloid proteins. Although amyloidosis is not a cancer but it is a serious condition. It is disabilitating and gets to life threatening. However, growing aware- ness of the condition seems to be leading to substantial new research and Rx alternatives.

Through “The Amyloidosis Foundation” they provide over the world medical facilities/hospitals that major in this disease at http://www.amyloidosis.org/PatientPrograms/physiciansusa.html.

“For diabetes in particular, we know there’s a relationship between lack of glucose regulation and complications like blindness and kidney failure. So if you were diabetic and you knew that you could get your glucose in a tight, normal range just by adjusting your lifestyle, wouldn’t that be great?”

Eric Topol   MD, (born 1954 who is an American cardiologist, geneticist, and digital medicine researcher.)