QUOTE FOR WEDNESDAY

“An enzyme is a biological catalyst and is almost always a protein. It speeds up the rate of a specific chemical reaction in the cell. The enzyme is not destroyed during the reaction and is used over and over. A cell contains thousands of different types of enzyme molecules, each specific to a particular chemical reaction.”
 
National Human Genome Research Institute

What allows vital operations to keep the body alive and working  – ENZYMEs.

3X7340

                                                                                                                                      Enzymes are vital for processes to take place in our body without them they couldn’t take place.  What are enzymes exactly?   We have an many enzymes  in our body from our saliva to our pancrease.  Enzymes are specialized proteins that are produced by living cells to catalyze reactions in the body=breakdown.   Protein in the form of an enzyme acts as a catalyst.  A catalyst in action brakes down something, any chemical substance affected with the speed of reaction without being permanently altered by the reaction.  For a chemical or biochemical reaction to occur, a certain amount of energy is required=the activation energy.  Energy can be transformed from one state to another.  The role of an enzyme is to decrease the amount of energy needed to start the reaction.  Exactly how enzymes lower activation energies is not completely and fully understood but it is known that an enzyme attaches itself to one of the reacting molecules, this is called a substrate complex.  Thousands of enzymes exist but each kind can attach ONLY to one kind of substrate.  The enzyme molecule must fit exactly with the substrate molecule (just like how pieces in a jigsaw puzzle have to fit in their specific space of the picture).  Well, if the substrate and enzyme don’t perfectly match or fit properly no reaction takes place.  When they do fit perfectly the substrate molecule can react with other molecules in a synthesis reaction and when completed the enzyme is free to move on elsewhere to connect with another substrate molecule.  This whole process takes place quickly.  Clearly, enzymes are essential to the body’s overall homeostasis. (In order to lead a healthy life, we need to bring a balance in the way we lead our lifestyle.  Homeostasis is nothing but a mechanism which helps the human body maintain a balance between the internal and external environment).  Enzymes quickly perform catalyze chemical reactions and they also govern the reactions that occur.   Enzymes are named by adding the suffix “ase” to the name of their substrates.  For example there is:

The breaking down of starches = the enzyme that does this function is amylase.             (Know this about amylase, it is present in human saliva where it begins the chemical process of digestion; that starts in our mouth. Foods that contain much starch but little sugar, such as rice and potato, taste slightly sweet as they are chewed because amylase turns some of their starch into sugar in the mouth. The pancreas also makes amylase (alpha amylase) to hydrolyse dietary starch into disaccharides and trisaccharides which are converted by other enzymes to glucose to supply the body with energy.  There is even b and y amylases. Ending product on enzymes breaking down starches or carbohydrates gives us one thing only sugar.)                                                                                                                                                       The breaking down of sugars, like sucrose = the enzyme is sucrase.  The ending product of the enzyme is it breaks down complex sugars to more simple sugars in the body.                                                                                                                                                                             The breaking down of fats (lipids) = the enzyme is lipase.  Lipase perform essential roles in the digestion, transport and processing of dietary lipids in most if not all living organisms (example (triglycerides, fats, oils).Most lipases act at a specific position on glycerol backbone of lipid substrate (A1,A2 or A3 in the small intestines).  For example, human pancreatic lipase (HPL) is the main enzyme that breaks down dietary fats in the digestive system, converts triglyceride substrates found in ingested oils to monoglycerides and two fatty acids.  Know that glycerol is a simple sugar compound.  Enzymes deal with breaking down our foods because they take a major role in what we call the process digestion in the human body but notice what the ending result is of mostly every ingredient out of 3 of our food groups, which is SUGAR.  It’s because of the food already having some sugar in it but more importantly also the chemical reaction with the enzyme to allow the food to break down into smaller compounds to be utilized in the body=simpler sugar compounds which also plays a part in the entire digestion process.

 

So know sugar in the body is our fuel for energy but with our digestion process, in how it works is like this:  when the body gets a meal within 1 hour digestion starts in the stomach and complete in 6 to 8 hours depending on how large the meal is, especially if 3 large meals a day.  The foods if contain starches, fat, lipids they all break down to simple sugars that transfer to the bloodstream and whatever energy the body needs at that point the tissues with cells utilize it but when enough sugar is used and we have excess in the blood we than have the body store the extra sugar that first converts the glucose (active sugar) to glycogen (inactive sugar) in our liver.  The liver is only so big and when it reaches its optimal level of storage than the sugar gets stored in our fat tissue = WEIGHT GAIN.  This is the problem with people in America not understanding this process.  Plus as most people get older from 30 than to 40 years old and every 10 years after that till heaven we put cellulite on the body for 2 major reasons not eating as healthy due to the bikini and speedo fit not being the priority in life but getting the feet up after a hard day’s work is.  The other reason is we aren’t as active as when we were 20 or 30 years old and the metabolism naturally slows down unless you’re a Jack la Lanne.

 

How do we deal with this to prevent obesity?  Do what I did go on a 4-6 small meal/health snack diet.  Eat a meal every 3 hours with keeping fat, calories/sugar, carbohydrates in proper proportions to prevent excess sugar in the meals to not allow fat storage=weight gain.  Of course some exercise or activity daily or every other day helps tone the muscle and not let it flab due to cellulite.  Live healthier habits of living not just a month, 3 months or 6 months but make it your daily routine with treating yourself to foods you don’t eat daily to maintain a good weight and increase your health status to allow you to live a happier, longer and more exciting life.

Let’s not forget with enzymes they also break proteins down in our body:                                                                                                                                                                               The breaking down of proteins=Trypsin Proteins are large biological molecules consisting of one or more chains of amino acids.  Proteins perform a vast array of functions within living organisms, including catalyzing metabolic reactions, replicating DNA, responding to stimuli, and transporting molecules from one location to another.  Trypsin is a enzyme catalyst, which allows the catalysis of chemical reactions.   The ending product of the break down is amino acids not sugar.  Know high on a protein diet continuously for years can hurt the body also.

 

Enzymes deal with breaking down our foods because they take a major role in what we call the process digestion in the human body.  but notice what the ending result is of mostly every ingredient in our 4 food groups is; SUGAR.  It because of the food has some sugar in it but also the chemical reaction with the enzyme to allow the food to break down into smaller compounds to be utilized in the body with send through the entire digestion process.

 

There are risks with eating just high protein diets for long periods of time.  You put yourself at risk for:  Osteoporosis:  Research shows that women who eat high protein diets based on meat have a higher rate of bone density loss than those who don’t. Women who eat meat lose an average of 35% of their bone density by age 65, while women who don’t eat meat lose an average of 18%. In the long run, bone density loss leads to osteoporosis.

Kidneys:  A high protein diet puts strain on the kidneys.  It is well known that patients with kidney problems suffer from eating a high protein diet which is due to the high amino acids levels.                         A high-protein diet may worsen kidney function in people with kidney disease because your body may have trouble eliminating all the waste products of protein metabolism.

However, the risks of using a high-protein diet with carbohydrate restriction for the long term are still being studied. Several health problems may result if a high-protein diet is followed for an extended time:

Some high-protein diets restrict carbohydrate intake so much that they can result in nutritional deficiencies or insufficient fiber, which can cause health problems such as constipation and diverticulitis.

Some high-protein diets promote foods such as red meat and full-fat dairy products, which may increase your risk of heart disease.

If you want to follow a high-protein diet, do so only as a short-term weight-loss aid.  Also, choose your protein wisely. Good choices include fish, skinless chicken, lean beef, pork and low-fat dairy products. Choose carbs that are high in fiber, such as whole grains and nutrient-dense vegetables and fruit.

It’s always a good idea to talk with your doctor before starting a weight-loss diet. And that’s especially important in this case if you have kidney disease, diabetes or other chronic health condition.

So if you want to continue on high protein diets longer than 6 months know how to alkalize the body chemicals to decrease the proteins and there are supplements that can do that via the pharmacy or look up even online.

Before changing your always do a diet check with your doctor to make sure its cleared ok by the doctor since he knows your entire medical history.

QUOTE FOR TUESDAY:

“Information from the ongoing COVID-19 pandemic suggests that this virus is spreading more efficiently than influenza, but not as efficiently as measles, which is highly contagious.”

CDC (cdc.org)

COVID-19 and where we are at; including other pandemics in history!

Global coronavirus epidemic outbreak concept – 3D illustration

Coronavirus Cases:

5,532,110

Deaths:

347,243

Recovered:

2,319,216

Now Let Us Look At 1918-1919 H1N1 Swyne Flu statistics

CDC states: “The 1918 influenza pandemic was the most severe pandemic in recent history. It was caused by an H1N1 virus with genes of avian origin. Although there is not universal consensus regarding where the virus originated, it spread worldwide during 1918-1919. In the United States, it was first identified in military personnel in spring 1918. It is estimated that about 500 million people or one-third of the world’s population became infected with this virus. The number of deaths was estimated to be at least 50 million worldwide with about 675,000 occurring in the United States.”

So H1N1 affected 500 million people  1/3 of the world at that time.

H1N1 by 1918 killed 50 million deaths.

Covid-19 is not even close in numbers.  No comparison and there was a lock down 6 weeks in the US for H1N1 1918 to 1919. 

The 100-year anniversary of the 1918 pandemic and the 10-year anniversary of the 2009 H1N1 pandemic are milestones that provide an opportunity to reflect on the groundbreaking work that led to the discovery, sequencing and reconstruction of the 1918 pandemic flu virus. This collaborative effort advanced understanding of the deadliest flu pandemic in modern history and has helped the global public health community prepare for contemporary pandemics, such as 2009 H1N1, as well as future pandemic threats. ”

By the numbers of both pandemics this is shown to be true (Covid -19 compared to our deadliest pandemic 1918-1919 Swine Flu=The Spanish Flu doesn’t even come close in numbers of how many affected and killed).

Covid over 500,000 affected and H1N1  over 5,000,000. See the difference and we will get through this.

H1N1 in 2009-2010:

“From April 12, 2009 to April 10, 2010, CDC estimated there were 60.8 million cases (range: 43.3-89.3 million), 274,304 hospitalizations (range: 195,086-402,719), and 12,469 deaths (range: 8868-18,306) in the United States due to the (H1N1)pdm09 virus.”.
Ending line, history does repeat itself and there have been pandemics worse, similar, or less but significant in count to be called a pandemic.
We needed to lock down but now we are ready to reopen.   God willing it stays that way and by history pandemics the research on Covid-19 will get better in treating and being prepared for this.  Also, our economy will get better in time.

QUOTE FOR THE WEEKEND:

Asthma is a condition in which your airways narrow and swell and produce extra mucus. This can make breathing difficult and trigger coughing, wheezing and shortness of breath. For some people, asthma is a minor nuisance where for others it could be a lot worse.

MAYO CLINIC

National Asthma Month

 

 

 

airways impacted by asthma

Asthma is a chronic, or long-term, disease that inflames and narrows the airways of your lungs

Asthma causes a variety of symptoms that can worsen at any time, making breathing difficult. Asthma is a disease that cannot be cured, but it can be managed. Some days you may not have symptoms, but this doesn’t mean your asthma has gone away. Asthma doesn’t have to slow you down. There are things you can do to control your asthma.

Asthma may cause the linings of your airways to get swollen, and the muscles around them can get tight. Sometimes the swelling and tightness get much worse. This is called an exacerbation, or asthma attack. An asthma attack can happen with any kind of asthma. Over time, effects of uncontrolled asthma, such as increased inflammation and asthma attacks, may have long-term effects on your breathing leading to permanent damage to the lining of your airways.  Asthma attacks can be serious; that’s why it’s important for you to work with your healthcare provider to control your asthma.

Not all asthma is the same.

Asthma may be different for different people. Your healthcare provider may identify your type of asthma based on:

  • how often you have symptoms
  • nighttime awakenings
  • how often you’re using your rescue inhaler
  • if your asthma is keeping you from doing your normal activities
  • how well you’re breathing, based on a breathing test

Your healthcare provider may assign the type of asthma that you have based on the most severe category listed above.

Intermittent asthma

If your asthma affects you twice a week or less, your asthma may be intermittent. You may need a rescue inhaler up to 2 days per week. It’s the mildest kind of asthma, but it’s not risk free, so be sure to tell your healthcare provider about your symptoms, and find out what you can do to help keep them under control.

Persistent asthma

Unlike intermittent asthma, with persistent asthma you may have symptoms and other limitations more often.  Persistent asthma can be mild, moderate, or severe.  Sometimes your symptoms may go away on their own. But other times, uncontrolled asthma may get worse. So can the risk of an asthma attack. It’s important to talk to your healthcare provider about your symptoms, and any changes you notice. Your healthcare provider can work with you to help control your asthma symptoms and reduce your risk.

People with mild asthma may have symptoms more than twice a week, but not every day. They may be awakened 3-4 times a month by their asthma or use a rescue inhaler called a SABA more than 2 days a week. They typically have some minor limits to their activities, but have a normal score on breathing tests. People with mild persistent asthma may also have some risk of asthma attacks that require corticosteroids (like prednisone).

If you have mild asthma, your doctor may prescribe a long-term controller medication like low-dose inhaled corticosteroids, as well as your rescue inhaler. When your mild asthma is well controlled, you may not have any symptoms at all, but this doesn’t mean your asthma has gone away.

If you have mild asthma, talk to your healthcare provider to make sure you are getting the right medicines to control your symptoms, and to help avoid asthma attacks. You should ask your healthcare provider what to watch for, and how to prevent an attack.

If you have moderate asthma, you may have symptoms every day. People with moderate asthma may be awakened once a week or more by asthma but not nightly, or may need to use their rescue inhaler every day. Their asthma may cause some limitations to their regular activities. Breathing tests may show some limitations, too. People with moderate asthma may have some risk of asthma attacks that require corticosteroids (like prednisone). Work with your healthcare provider to see what you can do to help gain control of moderate asthma, reduce symptoms and awakenings, and the need for a rescue inhaler, with little or no interference in your normal activities.

If you have severe asthma, you’re not alone. With the help of your doctor, severe asthma can be controlled.  However, severe asthma affects roughly 5-10% of people with asthma. Uncontrolled severe asthma may include symptoms throughout the day, every day, or waking up every night due to asthma symptoms. You may need a rescue inhaler several times a day. People with severe asthma may have frequent asthma attacks that require oral corticosteroids, sometimes severe enough to send them to a hospital. Severe asthma may cause many limits to daily activities, and low scores on breathing tests.

Some risk factors that can play a part in whether you develop different types of asthma may include pollution, allergies, smoking, obesity, or genetics.

If your asthma is severe and uncontrolled, your healthcare provider may recommend a specialist, like an allergist or a pulmonary specialist (also called a pulmonologist). These doctors are specially trained to treat asthma. They can help you find the right combination of medication and self-care to help manage your

QUOTE FOR FRIDAY:

“Preeclampsia is a disorder that occurs only during pregnancy and the postpartum period and affects both the mother and the unborn baby. Affecting at least 5-8% of all pregnancies, it is a rapidly progressive condition characterized by high blood pressure and usually the presence of protein in the urine.  Early recognition of preeclampsia symptoms can save your life.”

Preeclampsia Foundation (preclampsiafoundation.org)

World Preeclampsia Day!

What is Preeclampsia?

 

Preeclampsia is a condition that occurs only during pregnancy. Some symptoms may include high blood pressure and protein in the urine, occurring after week 20 of pregnancy. Preeclampsia is often precluded by gestational hypertension. While high blood pressure during pregnancy does not necessarily indicate preeclampsia, it may be a sign of another problem. The condition affects at least 5-8% of pregnancies.

Preeclampsia, formerly called toxemia, is when a pregnant woman has high blood pressure, protein in her urine, and swelling in her legs, feet, and hands. It can range from mild to severe. It usually happens late in pregnancy, though it can come earlier or just after delivery.

Preeclampsia can lead to eclampsia, a serious condition that can have health risks for mom and baby and, in rare cases, cause death. Women with preeclampsia who have seizures have eclampsia.

If you have a mild case and your baby has not reached full development, your doctor will probably recommend you do the following:

  • Rest, lying on your left side to take the weight of the baby off your major blood vessels.
  • Increase prenatal checkups.
  • Consume less salt
  • Drink at least 8 glasses of water a day
  • Change your diet to include more protein

If you have a severe case, your doctor may try to treat you with blood pressure medication until you are far enough along to deliver safely, along with possibly bed rest, dietary changes, and supplements.

The only cure for preeclampsia is to give birth. Even after delivery, symptoms of preeclampsia can last 1 to 6 weeks or more.

You can help protect yourself by learning the symptoms of preeclampsia and by seeing your doctor for regular prenatal care. Catching preeclampsia early may lower the chances of long-term problems for both mom and baby.

Who is at risk for preeclampsia?

  • A first-time mom
  • Previous experience with gestational hypertension or preeclampsia
  • Women whose sisters and mothers who had preeclampsia
  • Women carrying multiple babies
  • Women younger than 20 years and older than age 40
  • Women who had high blood pressure or kidney disease prior to pregnancy
  • Women who are obese or have a BMI of 30 or greater

Preeclampsia Causes

Many experts think preeclampsia and eclampsia happen when a woman’s placenta doesn’t work the way it should, but they don’t know exactly why. Some think poor nutrition or high body fat might contribute. A lack of blood flow to the uterus could play a role. Genes are also a factor.

How do I know if I have preeclampsia?

At each prenatal checkup, your healthcare provider will check your blood pressure, urine levels, and may order blood tests which may show if you have preeclampsia. Your physician may also perform other tests that include: checking kidney and blood-clotting functions; ultrasound scan to check your baby’s growth; and Doppler scan to measure the efficiency of blood flow to the placenta.

Symptoms

Preeclampsia sometimes develops without any symptoms. High blood pressure may develop slowly, or it may have a sudden onset. Monitoring your blood pressure is an important part of prenatal care because the first sign of preeclampsia is commonly a rise in blood pressure. Blood pressure that exceeds 140/90 millimeters of mercury (mm Hg) or greater — documented on two occasions, at least four hours apart — is abnormal.

Other signs and symptoms of preeclampsia may include:

  • Excess protein in your urine (proteinuria) or additional signs of kidney problems
  • Severe headaches
  • Changes in vision, including temporary loss of vision, blurred vision or light sensitivity
  • Upper abdominal pain, usually under your ribs on the right side
  • Nausea or vomiting
  • Decreased urine output
  • Decreased levels of platelets in your blood (thrombocytopenia)
  • Impaired liver function
  • Shortness of breath, caused by fluid in your lungs

 

 

 

QUOTE FOR THURSDAY:

“According to the US Centers for Disease Control and Prevention, hemophilia occurs in approximately 1 in 5,000 live births. There are about 20,000 people with hemophilia in the US. All races and ethnic groups are affected. Hemophilia A is four times as common as hemophilia B while more than half of patients with hemophilia A have the severe form of hemophilia.  Von Willebrand disease (VWD) is the most common bleeding disorder, affecting up to 1% of the US population.”

National Hemophilia Foundation