“Darier’s disease is a dominantly inherited condition affecting skin, nails and mucosae.   Prevalence is estimated at 1 in 36 000 (in North-East England). Skin signs generally develop between 6 and 20 years of age, although lesions may be overlooked until aggravated by heat, sweating or sunlight.

Clinically, the distinctive lesion is a warty plaque formed by coalescing firm, greasy, skin-coloured papules. The seborrhoeic areas of the trunk and face are predominantly affected. Pruritus is common, occurring in 80% of patients, and may be intractable; pain is unusual. When flexures are involved, the lesions may be hypertrophic, fissured and malodorous.”

National Library of Medicine (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539598/)