“Depression-related anger can be a reaction to the perceived hopelessness of a situation or even frustration over recurring states of depression [source: MacManamy].

A problem that offers no effective solutions or positive outcomes is going to produce its fair share of frustration and anger. For similar reasons, anger is also a common stage of grief [source: Chakraburtty]. As is the case with depression, grief-induced anger is the result of a feeling of hopelessness and despair.”

Tom Scheve (Howstuffworks.com)

“Factor V deficiency disease is an extremely rare hematological disease.  A person with this condition suffers with being able to barely to clot their blood.”

National Hemophilia Foundation

“Prothrombin deficiency is a bleeding disorder that slows the blood clotting process. People with this condition often experience prolonged bleeding following an injury, surgery, or having a tooth pulled.”

NIH  U.S. National Library of Medicine

“Most people with the disease are born with it, though its warning signs may not show up for years. Some people may suspect they have a bleeding disorder when they have heavy bleeding after a dental procedure or, for women, during a menstrual period.  Von Willebrand disease can’t be cured. But with good treatment and self-care, most people with this disease can lead active lives.”

MAYO CLINIC

“In 1965, Dr. Judith Graham Pool published a paper on cryoprecipitate. In a major breakthrough, she discovered that the precipitate left from thawing plasma was rich in factor VIII. Because cryoprecipitate contained a substantial amount of factor in a smaller volume, it could be infused to control serious bleeding.”

Judith Graham Pool – A researcher at Stanford University 1960s

“According to the US Centers for Disease Control and Prevention, hemophilia occurs in approximately 1 in 5,000 live births. There are about 20,000 people with hemophilia in the US. All races and ethnic groups are affected. Hemophilia A is four times as common as hemophilia B while more than half of patients with hemophilia A have the severe form of hemophilia.”

National Hemophilia Foundation

“Acute renal failure is abrupt deterioration in renal function, which is usually, but not invariably reversible over a period of days or weeks, and usually accompanied by a reduction in urine volume.

In contrast; chronic renal failure is the clinical syndrome of the metabolic and systemic consequences of a gradual, substantial and irreversible reduction in the excretory and homeostatic functions of the kidneys.

Both of these conditions, if untreated, ultimately results in end stage renal failure where the death is likely without renal replacement therapy.”

National Kidney Foundation

1 in 3 American adults is at risk for kidney disease. What puts you at risk for kidney disease? Major risk factors include diabetes, high blood pressure, a family history of kidney failure and being age 60 or older.

National Kidney Foundation

“When the main artery down the front of the heart (LAD) is totally blocked or has a critical blockage, right at the beginning of the vessel, it is known as the Widow Maker. (The medical term for this is a proximal LAD lesion). No one knows exactly who came up with the term, but the reason they did is likely that if that artery is blocked right at the beginning of its course, then the whole artery after it goes down. This essentially means that the whole front wall of the heart goes down. As far as heart attacks go, this is a big one, with big consequences if not dealt with appropriately and FAST!”

Dr. Ahmed/myheart.net – an Interventional Cardiologist and Director of Structural Heart Disease at Princeton-Baptist Hospital.

“The widow maker is an alternate name for the anterior interventricular branch of the left coronary artery (LCA).  It oxygenates over 50% of the heart tissue, with its branches. The left main coronary artery branches into: Circumflex artery/Left Anterior Descending artery (LAD).

• This supplies the Circumflex artery – supplies blood to the left atrium, side and back of the left ventricle
• Left Anterior Descending artery (LAD) – supplies the front and bottom of the left ventricle and the front of the septum”.

American Heart Association (AHA)