“Anemia is the most common blood condition in the U.S. It affects about 3.5 million Americans.”

WEB M.D.

“Acute Renal Failure occurs when your kidneys suddenly become unable to filter waste products from your blood causing build up of toxins in the blood stream affecting numerous tissues.”

The Mayo Clinic

Kidney failure occurs when the kidneys lose their ability to function. To treat kidney failure effectively, it is important to know whether kidney disease has developed suddenly (acute) or over the long term (chronic). Many conditions, diseases, and medicines can create situations that lead to acute and chronic kidney disease. Acute kidney injury, also called acute renal failure, is more commonly reversible than chronic kidney failure since the chronic condition has lasted longer in the body affecting systems for several months to years (some decades). Acute Renal Failure is new to the body as opposed to chronic; making it higher odds this can be treated and cured.

When acute kidney injury (ARF) occurs, the kidneys are unable to remove waste products and excess fluids, which then build up in the body and upset the body’s normal chemical balance.*

The most common causes of acute kidney injury are:

-dehydration

-blood loss from major surgery or injury

-medicines such as nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, or the dyes (contrast agents) used in X-ray tests.

Symptoms depend on the cause of acute renal failure and can include:

• -Little or no urine output.
• -Dizziness upon standing.
• -Swelling, especially of the legs and feet.
• -Loss of appetite, nausea, and vomiting.
• -Feeling confused, anxious and restless, or sleepy.
• -Pain in the flank, which is felt just below the rib cage and above the waist on one or both sides of the back.*

If your signs and symptoms suggest that you have acute kidney failure, your doctor may recommend certain tests and procedures to verify your diagnosis. These may include:

• Urine output measurements. The amount of urine you excrete in a day may help your doctor determine the cause of your kidney failure.
• Urine tests. Analyzing a sample of your urine, a procedure called urinalysis, may reveal abnormalities that suggest kidney failure.
• Blood tests. A sample of your blood may reveal rapidly rising levels of urea and creatinine — two substances used to measure kidney function.  Most cases of acute kidney injury occur in people who are already in the hospital for other reasons. In these people, acute kidney injury is usually diagnosed when routine tests show a sudden increase in creatinine and blood urea nitrogen (BUN) levels. A buildup of these waste products in the blood points to a loss of kidney function!**
• Imaging tests. Imaging tests such as ultrasound and computerized tomography may be used to help your doctor see your kidneys.  Also commonly done is an ultrasound of the kidneys which may help determine whether kidney problems are acute or chronic. Normal-sized kidneys may be present in either condition, but when both kidneys are smaller than normal, chronic kidney disease is usually the problem.  This helps rule out acute from chronic.–correcting the cause and supporting the kidneys with dialysis until proper functioning is restored.
• Removing a sample of kidney tissue for testing. In some situations, your doctor may recommend a kidney biopsy to remove a small sample of kidney tissue for lab testing. Your doctor inserts a needle through your skin and into your kidney to remove the sample.

TREATMENT FOR ARF (reversible in most cases)

Treatment for acute kidney failure typically requires a hospital stay. Most people with acute kidney failure are already hospitalized. How long you’ll stay in the hospital depends on the reason for your acute kidney failure and how quickly your kidneys recover.

In some cases, you may be able to recover at home.

Treating the underlying cause of your kidney failure

Treatment for acute kidney failure involves identifying the illness or injury that originally damaged your kidneys. Your treatment options depend on what’s causing your kidney failure.

“There is no specific treatment for HPV, but there are treatments for health problems caused by HPV”.

The National Cancer Institute

How to avoid HPV and the health problems it can cause=PREVENTION, like almost every other disease.

You can do several things to lower your chances of getting HPV.

Get vaccinated. HPV vaccines are safe and effective. They can protect males and females against diseases (including cancers) caused by HPV when given in the recommended age groups (see “Who should get vaccinated?” below). HPV vaccines are given in three shots over six months; it is important to get all three doses.

Get screened for cervical cancer. Routine screening for women aged 21 to 65 years old can prevent cervical cancer.

For those sexually active do the following:

–The right way to do SAFE SEX is the safe way everytime. This can lower your chances of getting HPV. But HPV can infect areas that are not covered by a condom – so condoms may not give full protection against getting HPV.

• Be in a mutually monogamous relationship – or have sex only with someone who only has sex with you.All boys and girls ages 11 or 12 years should get vaccinated.The vaccine is also recommended for gay and bisexual men (or any man who has sex with a man) through age 26. It is also recommended for men and women with compromised immune systems (including people living with HIV/AIDS) through age 26, if they did not get fully vaccinated when they were younger.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       How do I know if I have HPV?
• ONE go to a doctor! Simply get tested and have the doctor examine your genital area.
• Unfortunately there is no test to find out a person’s “HPV status.” Also, there is no approved HPV test to find HPV in the mouth or throat.
• There are HPV tests that can be used to screen for cervical cancer. These tests are recommended for screening only in women age of 30 years or older. They are not recommended to screen men, adolescents, or women under the age of 30 years old.Most people with HPV do not know they are infected and never develop symptoms or health problems from it. Some people find out they have HPV when they get genital warts. Women may find out at age 30 years and older when they get an abnormal Pap test result (during cervical cancer screening). Others may only find out once they’ve developed more serious problems from HPV, such as cancers. *                                                                                                                                                                                                                                                                                                                                                                                                            HEALTH PROBLEMS related to HPV:  Health problems r/t this illness include genital warts and cervical cancer.
•  Genital warts: Before HPV vaccines were introduced, roughly 340,000 to 360,000 women and men were affected by genital warts caused by HPV every year.* Also, about one in 100 sexually active adults in the U.S. have genital warts at any given time.
• Cervical cancer: More than 11,000 women in the USA get Cervical Cancer caused by HPV.
• The Treatment for HPV:
• There is no treatment for the virus itself.
• However, there are treatments for the health problems that HPV can cause:
  1. Genital warts can be treated by you or your physician. If left untreated, genital warts may go away, stay the same, or grow in size or number.
  2. Cervical precancer can be treated. Women who get routine Pap tests and follow up as needed can identify problems before cancer develops. Prevention is always better than treatment.

  Other HPV-related cancers are also more treatable when diagnosed and treated early like any other cancer

• If you are pregnant and have HPV, you can get genital warts or develop abnormal cell changes on your cervix. Abnormal cell changes can be found with routine cervical cancer screening. You should get routine cervical cancer screening even when you are pregnant.
• What happens if pregnant with HPV?
• Every year approximately 17,600 women and 9,300 men are affected by cancers caused by HPV 
• Catch-up vaccines are recommended for males through age 21 and for females through age 26, if they did not get vaccinated when they were younger.
• PREVENTION IS THE KEY TO HPV and any other disease.  For HPV prevention=VACCINATION!

“Women may find out they have HPV when they get an abnormal Pap test result (during cervical cancer screening). Others may only find out once they’ve developed more serious problems from HPV, such as cancers.”

Centers for Disease Control and Prevention

Cervical Cancer. Carcinoma of Cervix. Malignant   neoplasm arising from cells in the cervix uteri.   Vaginal bleeding. Vector diagram.

What is HPV?

We see many commercials on TV lately that have adolescents or young adults talking about this disease. What is this abbreviation? Human Papillomavirus is its full name. About 79 million Americans are currently infected with HPV. About 14 million people become newly infected each year. HPV is so common that most sexually-active men and women will get at least one type of HPV at some point in their lives.

The CDC (Centers for disease control and prevention) states HPV is the most common sexually transmitted infection (STI), that it is a different virus than HIV and that HPV is so common that nearly all sexually active men and women get it at some point in their lives. CDC all states there are many different types of HPV, some types can cause health problems including genital warts and cancers but there are vaccines that can stop these health problems from happening=PREVENTION.

How is HPV is transmitted from one person to another?

 It is a STD so you can get HPV by having vaginal, anal, or even oral sex with someone who has the virus. It is most commonly spread during vaginal or anal sex. HPV can be passed even when an infected person has no signs or symptoms.

Anyone who is sexually active can get HPV, even if you have had sex with only one person or multiple (obviously the more partners you have the higher the chance of getting it). You also can develop symptoms years after you have sex with someone who is infected unfortunately where this makes it hard to know when you first became infected.

What health risks does HPV put people at if they have this diagnosis?

In most cases, HPV goes away on its own and does not cause any health problems. But when HPV does not go away, it can cause health problems like genital warts and cancer.

Genital warts usually appear as a small bump or group of bumps in the genital area. They can be small or large, raised or flat, or shaped like a cauliflower. A healthcare provider can usually diagnose warts by looking at the genital area.

Remember it can cause the BIG C!

HPV can cause cervical and other cancer forms including cancer of the vulva, vagina, penis, or anus. It can also cause cancer in the back of the throat, including the base of the tongue and tonsils.

Cancer often takes years, even decades, to develop after a person gets HPV. The types of HPV that can cause genital warts are not the same as the types of HPV that can cause cancers.

There is no way to know which people who have HPV will develop cancer or other health problems. People with weak immune systems (including individuals with HIV/AIDS) may be less able to fight off HPV and more likely to develop health problems from it.

“Most of the Amyloidosis have different treatments, therefore, the correct diagnosis is extremely important (since there is more than one type of Amyloidosis).”

“Amyloidosis can affect different organs in different people, and there are different types of amyloid.”

MAYO CLINIC

What is Amyloidosis?  Amyloidosis (am-uh-loi-DO-sis) is a rare disease that occurs when a substance called amyloid builds up in your organs. Amyloid is an abnormal protein that is usually produced in your bone marrow and can be deposited in any tissue or organ.

The cause of primary amyloidosis is unknown. The condition is related to abnormal and excess production of antibodies by a type of immune cell called plasma cells. Clumps of abnormal proteins build up in certain organs. This reduces their ability to work correctly.

Symptoms depend on the organs affected.  Amyloidosis frequently affects the heart, kidneys, liver, spleen, nervous system and digestive tract. Severe amyloidosis can lead to life-threatening organ failure. This disease can affect the tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys.  Skin changes, such as thickening or easy bruising, and purplish patches around the eyes, difficulty swallowing,

Symptoms include: enlarged tongue, difficulty swallowing, feeling full quickly when eating, and significant weight loss, diarrhea possibly with blood or constipation, abnormal heart rhythm, fatigue, numbness of hands or feet, shortness of breath, hoarseness or changing voice, swelling of your ankles and legs and joint pain.

Amyloid is produced in your bone marrow and can be deposited in any tissue or organ affecting the tissue and organs like stated previously. The specific cause of this condition depends on the type of amyloidosis present.

Unfortunately, there are many different types of amyloidosis.  Here are the types:

– Immunoglobulin light chain (AL) amyloidosis.  This is the most common type, can affect your heart, kidneys, skin, nerves and liver. It was previously known as primary amyloidosis. It occurs when your bone marrow produces abnormal antibodies that can’t be broken down. The antibodies are deposited in your tissues as amyloid, interfering with normal function.   Most people diagnosed with AL amyloidosis, the most common type, are age 50 or older, although earlier onset can occur.  This is  hard in preventing this disease from occurring.  Nearly 70 percent of people with AL amyloidosis are men.

– AA amyloidosis, mostly affects your kidneys but occasionally your digestive tract, liver or heart. It was previously known as secondary amyloidosis. It occurs along with chronic infectious or inflammatory diseases, such as rheumatoid arthritis or inflammatory bowel disease.  One way to prevent this is through good health to prevent chronic infections, possibly rheumatoid arthritis or inflammatory bowel disease.

– Hereditary (familial) amyloidosis, is an inherited disorder that often affects the liver, nerves, heart and kidneys. One type is caused by a certain amyloid (transthyretin amyloid) that can affect the nervous system or the heart.  This is hereditary and unlikely to prevent but see your MD regularly to be checked for it every 6 months or yearly.  See what your MD suggests if you know this is in your family. African-Americans have a greater risk of this type than do Caucasians. It is thought to be a significant cause of heart failure in African-American men.

– Dialysis-related amyloidosis, develops when proteins in blood are deposited in joints and tendons which end up causing pain, stiffness and fluid in the joints, as well as carpal tunnel syndrome. This type generally affects people on long-term dialysis.  Dialysis can’t always remove large proteins from the blood. If you’re on dialysis, abnormal proteins can build up in your blood and eventually be deposited in tissue. The good news regarding this type of amyloidosis is this condition is less common with modern dialysis techniques.

IN THE END WHAT THIS CONDITION LEAVES AS AN FINAL RESULT TO INTEFERE WITH NORMAL FUNCTION OF TISSUES/ORGANS IN THE HUMAN BODY:

1.) Amyloid can harm the kidneys’ filtering system=our toileting system of the human body which takes toxics out of the bloodstream dumping them into the urinary bladder that our body voids out of the body through urinating.  If this organ, the kidneys are affected, this ends up causing protein to leak from your blood into your urine. The kidneys’ ability to remove waste products from your body is lowered, which may eventually lead to kidney failure (if 100% failure occurs now hemodialysis starts causing the amyloidosis to be at risk for just getting worse, see above dialysis-related amyloidosis).

2.) Amyloid can harm the nervous system, which affects our electrical system of the human body.  You may experience pain, numbness or tingling of the fingers or numbness, lack of feeling or a burning sensation in your toes or the soles of your feet. If amyloid affects the nerves that control your bowel function, you may experience periods of alternating constipation and diarrhea. Sometimes amyloidosis affects nerves that control blood pressure, and you may experience dizziness or near fainting when standing too quickly, as a result of a drop in your blood pressure due to orthostatic hypotension occurring secondary to the nerves affecting the B/P.

3.) Amyloid if it affects the engine of the human body it will cause reduction of that organ’s function being the heart.  It causes your heart’s ability to fill with blood between heartbeats. Less blood is filled up in each chamber of the heart at the normal level an this causes the heart to pump out less cardiac output with each beat, especially the left ventricle of the heart that pumps out oxygenated blood throughout the body.  This causes less oxygenated blood to our tissues and like plumbing when the pipes (in this case the arteries with veins) cause back up in the running of blood which go back to the lungs first (does not take long) all the way down to the feet (this takes time).  This in the end can make you experience shortness of breath due to fluid build up in the lungs. If amyloidosis affects your heart’s electrical system, your heart rhythm may be disturbed.  This can put you into arrhythmias the longer you don’t take care of the situation the worse the rhythm will get.

You may go to your general practitioner first depending on your insurance coverage but if it is questionable or your GP thinks it amyloidosis you should be referred to a doctor who specializes in blood disorders (hematologist).  Be prepared with questions already written out at home when you see your doctor so you don’t walk out of the office knocking your head saying “I forgot to ask him…”.   That could be from signs and symptoms, causes, risk factors, tests, treatments/medications, etc…

End of Part One; stay tune for Part 2 tomorrow!