Hodgkin’s lymphoma — formerly known as Hodgkin’s disease — is a cancer of the lymphatic system, which is part of your immune system.

In Hodgkin’s lymphoma, cells in the lymphatic system grow abnormally and may spread beyond the lymphatic system. As Hodgkin’s lymphoma progresses, it compromises your body’s ability to fight infection.

Hodgkin’s lymphoma is one of two common types of cancers of the lymphatic system. The other type, non-Hodgkin’s lymphoma, is far more common.

Advances in diagnosis and treatment of Hodgkin’s lymphoma have helped give people with this diagnosis the chance for a full recovery. The prognosis continues to improve for people with Hodgkin’s lymphoma.

Hodgkin’s lymphoma signs and symptoms may include:

• Painless swelling of lymph nodes in your neck, armpits or groin
• Persistent fatigue
• Fever and chills
• Night sweats
• Unexplained weight loss — as much as 10 percent or more of your body weight
• Loss of appetite
• Itching
• Increased sensitivity to the effects of alcohol or pain in your lymph nodes after drinking alcoholMake an appointment with your doctor if you have any signs or symptoms that worry you.Doctors know that most Hodgkin’s lymphoma occurs when an infection-fighting cell called a B cell develops a mutation in its DNA. The mutation tells the cells to divide rapidly and to continue living when a healthy cell would die. The mutation causes a large number of oversized, abnormal B cells to accumulate in the lymphatic system, where they crowd out healthy cells and cause the signs and symptoms of Hodgkin’s lymphoma.Classical Hodgkin’s lymphomaSubtypes of classical Hodgkin’s lymphoma include:
• Classical Hodgkin’s lymphoma is the more common type of this disease. It can be broken down further into subtypes. People diagnosed with classical Hodgkin’s lymphoma have large, abnormal cells called Reed-Sternberg cells in their lymph nodes.
• Various types of Hodgkin’s lymphoma exist. The type is based on the types of cells involved in your disease and their behavior. Your type determines your treatment options.
• It’s not clear what causes Hodgkin’s lymphoma.
• When to see a doctor

• Nodular sclerosis Hodgkin’s lymphoma
• Mixed cellularity Hodgkin’s lymphoma
• Lymphocyte-depleted Hodgkin’s lymphoma
• Lymphocyte-rich classical Hodgkin’s lymphomaThis much rarer type of Hodgkin’s lymphoma involves large, abnormal cells that are sometimes called popcorn cells because of their appearance. Treatment may be different from the classical type. People with this type of Hodgkin’s lymphoma may have a better chance of a cure when the disease is diagnosed at an early stage.Factors that increase the risk of Hodgkin’s lymphoma include:
• Lymphocyte-predominant Hodgkin’s lymphoma

• Your age. Hodgkin’s lymphoma is most often diagnosed in people between the ages of 15 and 30, as well as those older than 55.
• A family history of lymphoma. Having a close family member who has Hodgkin’s lymphoma or non-Hodgkin’s lymphoma increases your risk of developing Hodgkin’s lymphoma.
• Your sex. Males are slightly more likely to develop Hodgkin’s lymphoma.
• Past Epstein-Barr infection. People who have had illnesses caused by the Epstein-Barr virus, such as infectious mononucleosis, are more likely to develop Hodgkin’s lymphoma than are people who haven’t had Epstein-Barr infections.
• A weakened immune system. Having a compromised immune system, such as from HIV/AIDS or from having an organ transplant requiring medications to suppress the immune response, increases the risk of Hodgkin’s lymphoma.
• Make an appointment with your family doctor or a general practitioner if you have any signs or symptoms that worry you. After your diagnosis, your doctor may refer you to a specialist who treats Hodgkin’s lymphoma, such as a hematologist, medical oncologist or radiation oncologist.
• Preparing for an appointment with your doctor

What you can do

• Be aware of any pre-appointment restrictions. At the time you make the appointment, be sure to ask if there’s anything you need to do in advance, such as restrict your diet before testing.
• Write down any symptoms you’re experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.
• Write down key personal information, including any major stresses or recent life changes.
• Make a list of all medications, vitamins or supplements you’re taking.
• Consider taking a family member or friend along. Sometimes it can be difficult to absorb all the information provided during an appointment. Someone who accompanies you may remember something that you missed or forgot.
• Write down questions to ask your doctor.

Your time with your doctor is limited, so preparing a list of questions can help you make the most of your time together.

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over points you want to spend more time on.

TURN INTO PART 2 ON MONDAY (tests, procedures and treatment for the disease).