“Idiopathic thrombocytopenic purpura (ITP) is the condition of having a low platelet count (thrombocytopenia) of no known cause (idiopathic).  Although most cases are asymptomatic, very low platelet counts can lead to a bleeding.Detection of antiplatelet antibodies in the blood is considered to confirm the diagnosis of ITP.[1] Treatment should be restricted to those patients with moderate or severe thrombocytopenia who are bleeding or at risk of bleeding. It should be limited in duration unless demonstrated that symptomatic thrombocytopenia persists. Patients with mild, asymptomatic thrombocytopenia, discovered incidentally on a routine blood count, should not be treated.”.

NCBI (U.S. Narional Library of Medicine/National Institute of Health)

COMPLICATIONS:

-A rare complication of ITP, bleeding into the brain, which can be fatal.

-Pregnancy

In pregnant women with ITP, the condition doesn’t usually affect the baby. But the baby’s platelet count should be tested soon after birth.

If you’re pregnant and your platelet count is very low or you have bleeding, you have a greater risk of heavy bleeding during delivery.

DIAGNOSIS:

1.  M.D. will exclude other possible causes of bleeding and a low platelet count, such as an underlying illness or medications being the cause of low platelet count, not ITP.

2. Take a history of the child or adult, including their family.

3. Complete blood count (CBC).  Looks at red blood, white blood and platelet cells counts.

4 Blood smear. This test is often used to confirm the number of platelets observed in a complete blood count.

5.Bone marrow exam. This test may be used to help identify the cause of a low platelet count, though the American Society of Hematology doesn’t recommend this test for children with ITP.  All cells (platelets) are produced in the bone marrow.  Bone marrow will be normal because a low platelet count is caused by the destruction of platelets in the bloodstream and spleen — not by a problem with the bone marrow.

TREATMENT:

People with mild idiopathic thrombocytopenic purpura may need nothing more than regular monitoring and platelet checks. Children usually improve without treatment. Most ITP adults will eventually need treatment as it gets worse or becomes chronic.

1-The M.D will stop any meds that inhibit platelet production=Anti-platelet Meds (Ex. aspirin, ibuprofen (Advil, Motrin IB, others), ginkgo biloba and warfarin, also known as Coumadin)

2-Drugs that suppress your immune system.  M.D. might start you on oral corticosteroid, such as prednisone and when platelet count is normal gradually decrease the dosing till no longer on it.  The problem is that many adults experience a relapse after stopping corticosteroids. A new course of corticosteroids may be pursued, but long-term use of these medications is unusual, due to its long term side effects. These include cataracts, high blood sugar, increased risk of infections and thinning of bones (osteoporosis).

3-Injections to increase your blood count (Ex. immune globulin (IVIG). This drug may also be used if you have critical bleeding or need to quickly increase your blood count before surgery. The effect usually wears off in a couple of weeks.

4-Drugs that boost platelet production.  Examples romiplostim (Nplate) and eltrombopag (Promacta) — help your bone marrow produce more platelets.

5-Other immune-suppressing drugs. Rituximab (Rituxan) helps reduce the immune system response that’s damaging platelets, thus raising the platelet count.

6-Removal of your spleen.

7-Other drugs. Azathioprine (Imuran, Azasan) has been used to treat ITP. But it can cause significant side effects.

Review all treatments with your personal doctor.

“Immune thrombocytopenic purpura (ITP) is a blood disorder characterized by a decrease in the number of platelets in the blood. Platelets are cells in the blood that help stop bleeding. A decrease in platelets can cause easy bruising, bleeding gums, and internal bleeding. This disease is caused by an immune reaction against one’s own platelets. It has also been called autoimmune thrombocytopenic purpura.  Thrombocytopenia meaning a decreased number of platelets in the blood and purpura refers to the purple discoloring of the skin, as with a bruise.”

John Hopkins Medicine

What is ITP?

ITP means idiopathic thrombocytopenic purpura which is an autoimmune disease. The immune system is mistakenly attacking and destroying good platelets.  In autoimmune diseases, the body mounts an immune attack toward one or more seemingly normal organ systems. In ITP, platelets are the target. They are marked as foreign by the immune system and eliminated in the spleen, the liver, and by other means. In addition to increased platelet destruction, some people with ITP also have impaired platelet production.

A normal platelet count is between 150,000 and 400,000/microliter of blood. If someone has a platelet count lower than 100,000/microliter of blood with no other reason for low platelets, that person is considered to have ITP.1 There is no accurate, definitive test to diagnose ITP.

SYMPTOMS: 

Simple to understand. Platelets are for clotting our blood; if the platelet count is high we clot too much if low, in ITP, we bleed easy to hemorrage.

With few platelets, people with ITP often have bleeding symptoms such as spontaneous bruising, petechiae (pe-TEEK-ee-ay), tiny red dots on the skin, Bleeding from the gums or nose, and for women, possibly heavy menses. More severe bleeding symptoms include blood blisters on the inside of the mouth, blood in the urine or stool, or bleeding in the brain.

Idiopathic thrombocytopenic purpura or immune thrombocytopenia affects children and adults. Children often develop ITP after a viral infection and usually recover fully without treatment. In adults, the disorder is often long term.

Treatments for the disease vary depending on the platelet count, severity of symptoms, age, lifestyle, personal preferences, and any other associated diseases. Some people may choose to not treat their disease and live with low platelets.

While it may seem like ITP is a simple disease, there are nuances to the diagnosis, differences in the disease between children and adults, and variations in how the disease responds to treatments.

TYPES OF ITP:

Newly diagnosed ITP: within 3 months from diagnosis
Persistent ITP: 3 to 12 months from diagnosis. During this phase, patients have not reached spontaneous remission or maintained a complete response off therapy
Chronic ITP: lasting for more than 12 months
Severe ITP: presence of bleeding symptoms that need treatment or need an increase from prior treatment
Refractory ITP: does not respond or is resistant to attempted forms of treatment

RISK FACTORS:

-Your sex. Women are two to three times more likely to develop ITP than men are.

-Recent viral infection. Many children with ITP develop the disorder after a viral illness, such as mumps, measles or a respiratory infection.

COMPLICATIONS:

-A rare complication of ITP, bleeding into the brain, which can be fatal.

-Pregnancy

In pregnant women with ITP, the condition doesn’t usually affect the baby. But the baby’s platelet count should be tested soon after birth.

If you’re pregnant and your platelet count is very low or you have bleeding, you have a greater risk of heavy bleeding during delivery.

DIAGNOSIS:

1.  M.D. will exclude other possible causes of bleeding and a low platelet count, such as an underlying illness or medications being the cause of low platelet count, not ITP.

2. Take a history of the child or adult, including their family.

3. Complete blood count (CBC).  Looks at red blood, white blood and platelet cells counts.

4 Blood smear. This test is often used to confirm the number of platelets observed in a complete blood count.

5.Bone marrow exam. This test may be used to help identify the cause of a low platelet count, though the American Society of Hematology doesn’t recommend this test for children with ITP.  All cells (platelets) are produced in the bone marrow.  Bone marrow will be normal because a low platelet count is caused by the destruction of platelets in the bloodstream and spleen — not by a problem with the bone marrow.

TREATMENT:

People with mild idiopathic thrombocytopenic purpura may need nothing more than regular monitoring and platelet checks. Children usually improve without treatment. Most ITP adults will eventually need treatment as it gets worse or becomes chronic.

1-The M.D will stop any meds that inhibit platelet production=Anti-platelet Meds (Ex. aspirin, ibuprofen (Advil, Motrin IB, others), ginkgo biloba and warfarin, also known as Coumadin)

2-Drugs that suppress your immune system.  M.D. might start you on oral corticosteroid, such as prednisone and when platelet count is normal gradually decrease the dosing till no longer on it.  The problem is that many adults experience a relapse after stopping corticosteroids. A new course of corticosteroids may be pursued, but long-term use of these medications is unusual, due to its long term side effects. These include cataracts, high blood sugar, increased risk of infections and thinning of bones (osteoporosis).

3-Injections to increase your blood count (Ex. immune globulin (IVIG). This drug may also be used if you have critical bleeding or need to quickly increase your blood count before surgery. The effect usually wears off in a couple of weeks.

4-Drugs that boost platelet production.  Examples romiplostim (Nplate) and eltrombopag (Promacta) — help your bone marrow produce more platelets.

5-Other immune-suppressing drugs. Rituximab (Rituxan) helps reduce the immune system response that’s damaging platelets, thus raising the platelet count.

6-Removal of your spleen.

7-Other drugs. Azathioprine (Imuran, Azasan) has been used to treat ITP. But it can cause significant side effects.

Review all treatments with your personal doctor.

“Your body needs cholesterol to build healthy cells, but high levels of cholesterol can increase your risk of heart disease. With high cholesterol, you can develop fatty deposits in your blood vessels. Eventually, these deposits grow, making it difficult for enough blood to flow through your arteries.”

MAYO CLINIC

“With all of the bad publicity cholesterol gets, people are often surprised to learn that it’s actually necessary for our existence.  What’s also surprising is that our bodies produce cholesterol naturally. But cholesterol isn’t all good, nor is it all bad — it’s a complex topic and one worth knowing more about.  Cholesterol is a substance made in the liver that’s vital to human life. You can also get cholesterol through foods. Since it can’t be created by plants, you can only find it in animal products like meat and dairy.”.

Healthline (www.healthline.com)

“Childhood obesity has more than doubled in children and quadrupled in adolescents in the past 30 years.  The prevalence of obesity was 18.5% and affected about 13.7 million children and adolescents.  The percentage of children aged 6–11 years in the United States who were obese increased from 7% in 1980 to nearly 18% in 2012, now 18.4%.   Similarly, the percentage of adolescents aged 12–19 years who were obese increased from 5% to nearly 21% over the same period, now is 20.6%.”

CDC

It is shown that there are high rates of obesity worldwide which have been attributed to a combination of genetics and environment. Myriad environmental exposures may contribute to obesity, including calorie-rich diets, sedentary behavior, stress, and overuse of antibiotics. Just as important as the types of exposures is the timing. The period from conception to adolescence is known to be especially sensitive to obesity risks influenced by maternal fitness and childhood diet and physical activity. Parental experiences and fitness before conception, generational effects, and early-life events can also affect adult health.

The “CDC-Centers for disease control and prevention” have obesity facts they present as follows:

• “Childhood obesity has more than doubled in children and quadrupled in adolescents in the past 30 years.
• The prevalence of obesity was 18.5% and affected about 13.7 million children and adolescents.
• The percentage of children aged 6–11 years in the United States who were obese increased from 7% in 1980 to nearly 18% in 2012, now 18.4%.   Similarly, the percentage of adolescents aged 12–19 years who were obese increased from 5% to nearly 21% over the same period, now is 20.6%.
• In 2012, more than one third of children and adolescents were overweight or obese.
• Overweight is defined as having excess body weight for a particular height from fat, muscle, bone, water, or a combination of these factors.
• Obesity is defined as having excess body fat.
• Overweight and obesity are the result of “caloric imbalance”—too few calories expended for the amount of calories consumed—and are affected by various genetic, behavioral, and environmental factors.”

WEB M.D. states “One third of children in the U. S. is overweight or obese, and this number is continuing to rise. Children have fewer weight-related health and medical problems than adults. However, overweight children are at high risk of becoming overweight adolescents and adults, placing them at risk of developing chronic diseases such as heart disease and diabetes later in life. They are also more prone to develop stress, sadness, and low self-esteem.

Children become overweight and obese for a variety of reasons. The most common causes are genetic factors, lack of physical activity, unhealthy eating patterns, or a combination of these factors. Only in rare cases is being overweight caused by a medical condition such as a hormonal problem. A physical exam and some blood tests can rule out the possibility of a medical condition as the cause for obesity.

Although weight problems run in families, not all children with a family history of obesity will be overweight. Children whose parents or brothers or sisters are overweight may be at an increased risk of becoming overweight themselves, but this can be linked to shared family behaviors such as eating and activity habits.

A child’s total diet and activity level play an important role in determining a child’s weight. Today, many children spend a lot time being inactive. For example, the average child spends approximately four hours each day watching television. As computers and video games become increasingly popular, the number of hours of inactivity may increase.”

The effects of childhood obesity impact a short time (if handled quick enough and obesity resolved) as opposed to a long lifetime of obesity. Childhood obesity has both immediate and long-term effects on a person’s health and well-being.

Presently by CDC, they state in this topic the following:

Childhood obesity is a serious problem in the United States putting children and adolescents at risk for poor health. Obesity prevalence among children and adolescents is still too high.

For children and adolescents aged 2-19 years¹:

• Hispanics (25.8%) and non-Hispanic blacks (22.0%) had higher obesity prevalence than non-Hispanic whites (14.1%).
• Non-Hispanic Asians (11.0%) had lower obesity prevalence than non-Hispanic blacks and Hispanics.

Here are childhood effects that can occur:

• Obese youth are more likely to have risk factors for cardiovascular disease, such as high cholesterol or high blood pressure. In a population-based sample of 5- to 17-year-olds, 70% of obese youth had at least one risk factor for cardiovascular disease versus if one of your parents has cardiac disease one out of a 4 children family are at risk of getting it (25%) just based on the parents history.
• Obese adolescents are more likely to have pre-diabetes, a condition in which blood glucose levels indicate a high risk for development of diabetes.
• Children and adolescents who are obese are at greater risk for bone and joint problems, sleep apnea, and social and psychological problems such as stigmatization and poor self-esteem.

Long-term health effects that can occur:

• Children and adolescents who are obese are likely to be obese as adults and are therefore more at risk for adult health problems such as heart disease, type 2 diabetes, stroke, several types of cancer, and osteoarthritis.  One study showed that children who became obese as early as age 2 were more likely to be obese as adults. Overweight and obesity are associated with increased risk for many types of cancer, including cancer of the breast, colon, endometrium, esophagus, kidney, pancreas, gall bladder, thyroid, ovary, cervix, and prostate, as well as multiple myeloma and Hodgkin’s lymphoma.
• One of the best strategies to reduce childhood obesity is to improve the diet and exercise habits of your entire family. Treating and preventing childhood obesity helps protect the health of your child now and in the future.

The KEY to stopping childhood obesity into adulthood from is through Prevention (which starts in childhood):

• Healthy lifestyle habits, including healthy eating and physical activity, can lower the risk of becoming obese and developing related diseases.
• The dietary and physical activity behaviors of children and adolescents are influenced by many sectors of society, including families, communities, schools, child care settings, medical care providers, faith-based institutions, government agencies, the media, and the food and beverage industries and entertainment industries.
• Schools play a particularly critical role by establishing a safe and supportive environment with policies and practices that support healthy behaviors. Schools also provide opportunities for students to learn about and practice healthy eating and physical activity behaviors.

To prevent obesity and overweight in children we need our communities throughout the world to:

• Promote improvements to the nutritional value of the food children eat in schools, child care centers and after-school programs.
• Support increasing children’s physical activity through improved compliance with physical education mandates by New York City schools, as well as through making physical activities available in after-school programs and City parks and playgrounds.
• To increase education for children and parents about good nutrition, why healthy food choices are important, and how to combat obesity.
• To support efforts that help all in every state of America and in the world making healthy food choices, such as laws eliminating trans-fats, and policies to tax or limit the sizes of sugary beverages. Which has already started in many areas but we need to keep doing it and making it stronger for the children health now in their future.

“During atrial fibrillation, the heart’s two upper chambers (the atria) beat chaotically and irregularly — out of coordination with the two lower chambers (the ventricles) of the heart.  Sometimes the misfiring signals can also make your heart’s two bottom chambers, called ventricles, beat too quickly. That’s a specific type of atrial fibrillation called AFib with rapid ventricular response.  Any type of AFib can lead to a stroke or heart failure. If you don’t get treated, over time the condition can damage your heart muscle and lead to heart failure.”.

WebMD

Top Line is Controlled AFIB less than 100 bts/min. Look how many spikes there are on the top line that’s the HR/min 8spikes x 10=80 in a 6 second strip from a EKG machine.  Controlled afib is your HR under 100/min. 

Bottom Line is Normal ( Sinus) rhythm, see how evenly spaced the spikes are. The rhythm rate is 5 spikes x 10=50 or a pulse or HR in a 6 second strip from a EKG machine. It’s not irregular and no stress to the heart.

A regular HR allows the heart chambers to fill up properly as opposed to irregular.  This allows less stress on the heart.  Ex an engine running properly in our car as opposed to not running properly puts a high potential for the engine to go into problems.  Same with an irregular HR for the heart.

Each spike represents a heart pulsation which is when the organ is going lub dub, when the heart is contracting then relaxing, add them up on each strip on a 6 second strip (those above) x 10 tells you the heart rate by counting the spikes than x 10=that person’s heart rate.  The first strip above is only 80 of a heart rate in 60 seconds and the next one is in RVR=280 of a HR.  The heart can only take that so long before going into a worse rhythm called V-Tac or Ventricular Fibrillation and have to be shocked.  So it is vital to keep atrial fibrillation under control meaning pulse under 100 beats a minute.  Remember in a-fib. your upper chambers are in fibrillation (just quivering) as opposed to ventricular fibrillation, which is when we shock a pt. to knock their rhythm back to a better rhythm to stay alive.  In Vent.Fib. untreated results into death since the chambers are doing nothing but quivering.  The brain can live only 7 seconds without oxygen and barely any 02 is getting to your tissues in this rhythm.

   The heart is our ENGINE!

Some people in the US have this cardiac condition called Atrial Fibrillation where some with this condition even experience Rapid Ventricular Rate or Response with it.

Atrial fibrillation is an irregular and often rapid heart rate that commonly causes poor blood flow to the body.

During atrial fibrillation, the heart’s two upper chambers (the atria) beat chaotically and irregularly — out of coordination with the two lower chambers (the ventricles) of the heart causing your pulse to be irregular. We know now how the blood flows through the heart but due to the irregularity of the atriums which is not allowing the chambers to fill up to the maximal level they normally did when they didn’t have Atrial Fibrillation is decreasing the cardiac output (blood volume) from the left ventricle to be decreased.   This means the heart and all other tissus aren’t getting the regular amount of oxygen they got when they were in a regular normal rhythm.  Atrial fibrillation symptoms often include heart palpitations, shortness of breath and weakness.  Atrial fibrillation (also called AFib or AF) is a quivering or irregular heartbeat (arrhythmia) that can lead to blood clots, stroke, heart failure and other heart-related complications. Some people refer to AFib as a quivering heart.  What happens here is primarily the ventricles take over.   With the atriums quivering and the ventricles going at their rate this causes an irregular heart rate=HR.  Another problem with an irregular heart rate is this allows blood to pool in the heart putting the patient at risk for clot formation.  As this HR gets more irregular it puts the patient at a higher risk of allowing the clot to break off inside the heart now flowing freely in the blood stream.  If it reaches the lungs and stays there a pulmonary thrombus can occur causing breathing difficulties; if it bypasses the lungs the next place it goes to is the brain putting the person at risk for a stroke and if it reaches back to the heart the patient can have a heart attack.  This why you commonly see patients with atrial fibrillation on the med Coumadin or some form of anticoagulant drug to prevent clots from occurring.

An estimated 2.7 million Americans are living with Afib.

Episodes of atrial fibrillation can come and go, or you may develop atrial fibrillation that doesn’t go away and may require treatment. Although atrial fibrillation itself usually isn’t life-threatening if kept under control meaning HR under 100, it is a serious medical condition that sometimes requires emergency treatment. It can lead to complications. Atrial fibrillation may lead to blood clots forming in the heart that may circulate to other organs and lead to blocked blood flow (ischemia) to even stroke (cause the clot reached the brain or heart attack  cause the clot is in the heart) to pulmonary thrombus (cause the clot reached the lungs), as stated earlier.

Treatments for atrial fibrillation may include medications like anticoagulants primarily=Coumadin, Plavix, antiplatelets=aspirin (platelets are responsible for clotting in our bloodstream) with and other interventions to try to alter the heart’s electrical system such as cardioversion-shocking the heart at low level voltage, more common in newly diagnosed afib. in hope to knock the afib into a regular rhythm called normal sinus rhythm (the best rhythm to be in).  We have a normal sinus node in our right upper chamber that gives the signals for our pulsation of the heart and is the reason the best rhythm is called sinus normal rhythm.

Various studies have reported that electrical cardioversion is over 90 percent effective in converting to a normal sinus rhythm though many people revert back into afib shortly thereafter. Success has been shown to be enhanced when patients are on an anti-arrhythmic drug beforehand, which helps prevent reverting back to atrial fibrillation.

Success depends on the size of the left atrium as well as how long the patient has been in a=fib.. Patients with a very large left atrium, one greater than 5 cm, or who have been in constant a-fib for a year or two, may find that electrical cardioversion is not effective in converting to or maintaining a normal sinus rhythm (the best heart rate to be in; remember the natural pacemaker of the heart lies in our right upper side of the chamber on the lateral side not the medial side which we call the Sinus Node.  The sinus rhythm derives from this sinus node, that is why its the best rhythm to be in especially if your under HR is from 60 to less than 100.  Ideal HR a minute is 60-80s.).

Following a successful electrical cardioversion to treat uncontrolled atrial fibrillation (in the medical abbreviated by calling it afib also), the goal is to maintain a normal sinus rhythm, which only happens with about 20–30 percent of patients within the first year if they are not on anti-arrhythmic drugs for rhythm control. Overall, the likelihood is quite high that you will revert back into atrial fibrillation, regardless of whether you stay on rhythm control drugs.

Always remember if you remain in Atrial Fibrillation and the HR is kept under 100 with no symptoms you can live a completely normal life.  Also always follow up with your cardiologist to keep an eye on your rhythm with following the M.D. treatment.

When the ventricles beat too rapidly they don’t fill completely with blood from the atria. As a result, they cannot efficiently pump blood out to meet the needs of the body. This can ultimately lead to heart failure in time if not treated.  Just like us running from NY to California most will end up not being able to do it just like the heart can’t run in atrial fibrillation in a high heart rate for a long time,  it also will give out going into failure.  The heart can only compensate in atrial fibrillation in a rapid high heart rate for so long than stop if no treatment is done.

A cardiac condition called Rapid Ventricular Rate or Response which is seen sometimes with Atrial Fibrillation which is the heart is overloaded.  Our heart beats lub dub which is first the atriums opening and closing (lub) and than the ventricles opening and closing (dub).  When the heart gets overworked and tries to compensate the atriums can give up and just allow the ventricles to take over to beat which affects the heart and all other tissues to get proper amount of blood with oxygen in time.  Since you loose the atriums (the upper chambers of the heart) and they don’t fill up with the amount of blood volume like they use to before having afib+.  You loose a lot of blood volume(RBC’s); what the heart pumps out in the left ventricle to our tissues with oxygen get’s decreased in what we call your cardiac output=the volume of oxygenated blood pumped out of the left ventricle.  Well with atrial fibrillation this gets compensated.  In time if this is not repaired the blood goes backwards in how the heart pumps the blood.  It is regurgitating blood back in the heart back in the pulmonary vein back to the lungs putting fluid in the lungs even going further back into the Rt side of the heart if it is reaching that far and then superior vena cava and even further depending how long this hasn’t been treated.  Heart failure is set up, if not already diagnosed.

Heart failure can result of Atrial Fibrillation with RVR overtime and is the most common in those who already have another type of heart disease like CAD (Coronary Heart Disease, CHF,  heart valve disease etc…).

RVR can cause chest pains and make conditions like congestive heart failure worse (they are already with a heart not functioning at its optimal).   RVR is simply having a high heart rate with the ventricles only pumping.  The HR can be like over 100-280.  You need to get to an ER to be treated immediately.  This is where you would be started on a IV drip like Cardizem to bring the HR down to get you in controlled atrial fibrillation or some type of medication in bringing the HR down to cardioverted after cleared you have no clot in your heart especially since the shock can make it loose in your bloodstream.  We already reviewed earlier what a loose clot can cause.  HR meaning the heart rate or pulse which just like a car if not maintained properly it will wear down till it no longer works or dies!  Be could to your heart you only have one unless you get a transplant which is very hard to obtain; and why bother for if you control your a-fib it will allow you to live a completely normal life if that is your only medical  or medical condition you have.  Its all up to you!