LOOKING AT ACTUAL STUDIES SUPPORTING OBESITY&CANCER LINK

Take for example through the American Cancer Society they stated in an article 2006 that a substantial evidence from clinical trials has established that obesity significantly increases the risk for heart disease and diabetes. More recently, suspicions that obesity is linked to prostate cancer have been supported by a number of investigations, but the relationship has remained unclear. Now through a pair of new studies provides scientists with some important insights that may have an impact on how physicians manage their patients with prostate cancer.

The pair of studies show 2 significant studies relating how obesity links with prostate cancer, which were:

The implication is that prostate cancer patients who are obese should probably be followed more closely than patients with similar cancer characteristics who are not obese. That could include regular digital rectal exams, more frequent prostate-specific antigen (PSA) testing, and perhaps setting a lower PSA cutoff point as an indication of recurrence, Kane explained.

The greater risk associated with obesity may be related to technical issues, Kane said. For example, it’s more difficult for surgeons to perform a radical prostatectomy in obese patients. However, surgical challenges offer only a partial explanation. In studies where surgeons verified that they had removed all cancer cells during radical prostatectomy, obese patients were still more likely to experience a recurrence of the disease.

The second study, a multi-center trial coordinated at the Duke University School of Medicine in Durham, NC, found that obese men under the age of 63 tend to have larger prostates, which makes finding tumors more difficult. As a result, there’s a real danger of delayed diagnosis, which decreases the chances of a cure and puts patients at greater risk for dying of the disease. The findings appear in the Journal of Urology.

“It’s harder to find cancer in larger prostate glands,” explained Stephen J. Freedland, MD, assistant professor of urology and member of the Duke Prostate Center at the Duke University School of Medicine. “Consequently, our data suggest that we may be underdiagnosing cancers in younger obese men. That also means that the tumors we do pick up are likely to be at a more advanced stage and perhaps more aggressive, and therefore more difficult to treat.”

Let’s look at this at a broader aspect, not just pertaining to prostate cancer. This would be, “It’s not just patients with prostate cancer that studies like this should be directed toward,” Dr. Kane said. “Patients who are clearly at risk for developing the disease should also take notice of our findings. The central message is yet again that obesity has been identified as an important risk factor for a potentially deadly disease. For all of us, controlling our weight through diet and exercise is important, and we shouldn’t have blinders on and just think of prostate cancer. The number one risk of death for American men is heart disease, so anything we can do to reduce that risk that also reduces the risk for prostate cancer is useful.” Including it reduces risk for other cancers as well that are impacted by disease, it makes sense.

Obesity links to an increased risk of ovarian cancer. Let’s look at this no: Atlanta 2009/01/05 -A new epidemiological study has found that among women who have never used menopausal hormone therapy, obese women are at an increased risk of developing ovarian cancer compared with women of normal weight. Published in the February 15, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the research indicates that obesity may contribute to the development of ovarian cancer through a hormonal mechanism. Ovarian cancer is the most fatal of gynecologic malignancies, and has a 5-year survival rate of only 37 percent.

To investigate this issue, Dr. Michael F. Leitzmann of the National Cancer Institute and colleagues studied 94,525 U.S. women aged 50 to 71 years over a period of seven years. The researchers documented 303 ovarian cancer cases during this time and noted that among women who had never taken hormones after menopause, obesity was associated with an almost 80 percent higher risk of ovarian cancer. In contrast, no link between body weight and ovarian cancer was evident for women who had ever used menopausal hormone therapy.

According to Dr. Leitzmann, these findings support the hypothesis that obesity may enhance ovarian cancer risk in part through its hormonal effects. Excess body mass in postmenopausal women leads to an increased production of estrogen, which in turn may stimulate the growth of ovarian cells and play a role in the development of ovarian cancer.

In another study done 2003, American Cancer Society researchers analyzed data based on 900,000 American adults with obesity and cancer that they monitored for a total of 16 years. This is what they found in their landmark study: 1)The researchers found that the most obese women had a 62% increase in their risk of dying from cancer than women of normal weight; for obese men, the increase was 52%. The wide range of tumor types included colorectal, liver, gallbladder, pancreas, esophageal, kidney, prostate, breast, uterine, endometrial, and ovarian cancers. The researchers conclusion was that above-normal weight was associated with almost 20% of all cancer deaths in the United States. “There’s an incredibly powerful link between obesity and cancer,” says oncologist Joyce Slingerland of the University of Miami, Florida. “Everyone’s heard of obesity’s effect on heart disease and diabetes, and we’re now beginning to understand that the cancer risk is just as great,” she says.

Although researchers and epidemiologists had long suspected that diet and cancer were linked, efforts to explain why being fat makes cancer more deadly have only begun to deliver results in the past decade.

So it is up to the people in society of that country they live in to take on responsible actions to make their country a better for all, not just one. I say that is becoming as healthy as possible that an individual can reach and without America has the answers in knowing how to make this happen 100% in our country.

A new study from American Cancer Society researchers finds it’s not just how much physical activity you get, but how much time you spend sitting that can affect your risk of death.

My final study supporting how obesity links with cancer:

Just think if this was you or someone you know in the world and this happens to you or them; GOD FORBID, but you can help yourself through prevention with losing the weight or just staying slim and tone if you already are. This will just decrease your risk of getting the cancer.

The JCCC study, led by Dr. Guido Eibl, JCCC member and professor-in-residence in the department of surgery at David Geffen School of Medicine, revealed that mice made obese with high-calorie, high-fat diets developed abnormally high numbers of these lesions.

This is the first study to show a direct causal link in an animal model between obesity and risk of this deadly pancreatic cancer.

The JCCC study, led by Dr. Guido Eibl, JCCC member and professor-in-residence in the department of surgery at David Geffen School of Medicine, revealed that mice made obese with high-calorie, high-fat diets developed abnormally high numbers of these lesions. This is the first study to show a direct causal link in an animal model between obesity and risk of this deadly pancreatic cancer.

The mice eating the normal diet gained an average of approximately 7.2 g over 14 months. Mice on the high-fat, high-calorie diet more than doubled this with an average weight gain of 15.9 g.

Pathological tests showed that mice fed the normal diet had mostly normal pancreases with very few scattered PanIN lesions=intraepithelial neoplasias=precursors to pancreatic lesions. They are used as markers but can only be seen microscopically so a biopsy is needed. The mice fed high fat & cholesterol in their diet had significantly more PanIN lesions with less overall healthy pancreases.

The study showed that the mice fed a diet high in fats and calories gained significantly more weight, had abnormalities of their metabolism and increased insulin levels, and had marked pancreatic tissue inflammation with the development of PanIN lesions.

These observations suggest that such a diet like this which leads to weight gain, metabolism disturbances, pancreas inflammation and pancreas lesions that are precursors to cancer.

Obviously research is showing obesity has a link with cancer. We now know this information let’s make a move America and people elsewhere to become a healthier nation including world. For diversity is the US and other countries filled with all cultures, races and genders need to learn this knowledge to help make their country whether they were either born there and stayed or those born elsewhere moving to a new country, like America and we the people making up the country need to be responsible not just for yourselves but for your children and future generations in spreading good habits, good dieting, and good exercise to prevent high disease in the country for yourself and your children and the future generations by being a good role model in thinking=live healthy not unhealthy. In time this would play an impact on your countries economy and health care system in how its run. So come with me, like many others if you need to know the simple steps in how to go about losing weight safely but easy with learning better healthy habits and practicing some form of exercise which will benefit you in having a healthier body than join me at my website healthyusa.tsfl.com and become a member with getting guidance through Dr. Anderson on his healthy habits through his book and me as your health coach. Take a peek you might just like what you see. You make all the choices in what you want and going to the site costs nothing. There will come a point you get your routine down and don’t need our help with staying healthy for life with decreasing your chance of so many diseases, not just cancer, from occurring. Help me with so many others in tring to make a difference in America by becoming healthier. Slowly but surely I am and I know you can to at your pace.

References:

1 –American Institute for Cancer Research, Schernhammer ES et al. Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):699-704 ES et al. their binding proteins, and breast cancer risk— Cancer Epidemiol Biomarkers Prev. 2006 Mar;14(3):699-704/ AICR ScienceNow /Volume 16/Spring 2006

2 – Studies Help Clarify Link Between Obesity and Prostate Cancer  Article date: March 2, 2006 Impact of Obesity on Prostate Cancer Recurrence After Radical Prostatectomy: Data from CaPSURE.” Published in the Nov., 2005 Urology (Vol. 66, No. 5: 1060-1065). First author: William W. Bassett, University of California, San Francisco.

“Obesity, Serum Prostate Specific Antigen and Prostate Size: Implications for Prostate Cancer Detection.” Published in the Feb. 2006 Journal of Urology (Vol. 175, No. 2: 500-504). First author: Stephen J. Freedland, MD, Duke University School of Medicine.

3 – Director, Medical & Scientific Communications American Cancer Society david.sampson@cancer.org Article: “Body mass index and risk of ovarian cancer.” Michael F. Leitzmann, Corinna Koebnick, Kim N. Danforth.

“In the United States, 1 in 3 people will be diagnosed with cancer during their lifetime. Here is some information to help you better understand what cancer is.

Cancer needs to be understood that it is more than just one disease. There are many types of cancer, and it can develop anywhere in the body. Cancer is a group of diseases where abnormal cells grow out of control and crowd out normal cells. It affects 1 in 3 people in the United States. Chances are that you or someone you know has been affected by cancer.

There are many different kinds of cancer, but they all involve abnormal cells. Cancers often have these features:

• Gene changes (mutations): Cancer cells have changes in their genes that make them abnormal. Some of these gene changes may be passed down from a parent (inherited mutations), while others may happen later in life (acquired mutations).
• Uncontrolled cell growth: Most abnormal cells die off or are unable to reproduce. But cancer cells can keep growing and dividing to make more abnormal cells. Cancer cells can crowd out normal cells.
• Tumor formation: Not all cancer cells form tumors, and not all tumors are cancer. But many types of cancer cells do clump together to form tumors.
• Cancer spread (metastasis): Cancer cells can invade nearby tissues, and many can even spread to other parts of the body.

Many types of abnormal cell growths have some of these features, but not all of them are cancer.

Cancer starts when something goes wrong in the normal process of cells growing and dividing to make new cells. A cell’s genes (pieces of DNA that tell the cell how to function) change and make the cell abnormal. Most cells die if they become abnormal, but some gene changes allow cells to survive, grow, and divide to make more abnormal cells.

Gene changes that lead to cancer can have many possible causes. Lifestyle habits, genes you get from your parents, and being exposed to certain chemicals or radiation can all play a role. Many times, there is no clear cause.

Cancers are often grouped into two main categories:

• Blood (hematologic) cancers start in blood cells or blood-forming tissues. These include leukemia, lymphoma, and multiple myeloma.
• Solid tumor cancers develop in organs or tissues. The most common solid tumors are breast, prostate, lung, and colorectal cancers.

It’s very important to know the type (and subtype) of cancer before starting treatment, if possible. Knowing the exact type helps doctors know which treatment will work best.”

American Cancer Society (What Is Cancer? | Cancer Basics | American Cancer Society)

There is steps you can take early in life and steps you can take through out your life to prevent cervical cancer:

1. Three HPV vaccines—9-valent HPV vaccine (Gardasil 9, 9vHPV), quadrivalent HPV vaccine (Gardasil, 4vHPV), and bivalent HPV vaccine (Cervarix, 2vHPV)—have been licensed by the U.S. Food and Drug Administration (FDA). All three HPV vaccines protect against HPV types 16 and 18 that cause most HPV cancers.

Gardasil 9 is an HPV vaccine approved by the U.S. Food and Drug Administration and can be used for both girls and boys. This vaccine can prevent most cases of cervical cancer if the vaccine is given before girls or women are exposed to the virus. This vaccine can also prevent vaginal and vulvar cancer.

2. For cancer prevention as well as overall health and wellness through out your life, many experts recommend a plant-based diet that consists primarily of fruits, vegetables, beans and whole grains. These foods contain a variety of beneficial chemical compounds that can be easily incorporated into daily meals. Some examples include:

• Flavonoids – These chemical compounds, which are believed to provide protection against cancer, are found in apples, asparagus, black beans, broccoli, brussels sprouts, cabbage, cranberries, garlic, lettuce, lima beans, onions, soy and spinach.
• Folate – This water-soluble B vitamin has been found to reduce the risk of cervical cancer in women who have HPV. Foods that are rich in folate include avocados, chickpeas, lentils, orange juice, romaine lettuce and strawberries.
• Carotenoids – These valuable sources of vitamin A are found in most fruits, vegetables and beans, and particularly in orange foods such as carrots, sweet potatoes, pumpkin and squash.

While a healthy diet is an important component of an overall cancer prevention plan, it should not be the only component.

Treatment of cervical cancer:

Cervical cancer treatments include surgery, chemotherapy, and radiation therapy. If your doctor says that you have cervical cancer, ask to be referred to a gynecologic oncologist—a doctor who has been trained to treat cancers of a woman’s reproductive system.

Different treatments may be provided by different doctors on your medical team.

• Gynecologic oncologists are doctors who have been trained to treat cancers of a woman’s reproductive system.
• Surgeons are doctors who perform operations.
• Medical oncologists are doctors who treat cancer with medicine.
• Radiation oncologists are doctors who treat cancer with radiation.

You always go with MD specialist in treating any cancer starting with a oncologist who will work you up with further specialists if needed.

Memorial Sloan Kettering Cancer Center in NYC states:

“Early-stage cervical cancer can often be treated with surgery. It’s possible you may not even need other forms of treatment, such as chemotherapy or radiation. The key to treating early-stage cancers or precancers is to catch them early.

Each year, approximately 200 women with cervical cancer, and 50 with invasive disease, come to us for care. The outlook for women with cervical cancer has never been better. And our doctors and specialists are always looking for new ways to improve the treatment options for women with this disease.”

“Key facts

• Cervical cancer is largely preventable through HPV vaccination and regular screening, as recommended by national guidelines, and it can be cured if detected early and treated promptly.
• Cervical cancer is the fourth most common cancer in women globally with around 660 000 new cases and around 350 000 deaths in 2022.
• The highest rates of cervical cancer incidence and mortality are in low- and middle-income countries. This reflects major inequities driven by lack of access to national HPV vaccination, cervical screening and treatment services and social and economic determinants.
• Cervical cancer is caused by persistent infection with human papillomavirus (HPV). Women living with HIV are 6 times more likely to develop cervical cancer compared to women without HIV.
• Countries worldwide are accelerating efforts to eliminate cervical cancer, guided by the global 90–70–90 targets: 90% of girls fully vaccinated with HPV vaccine by age 15, 70% of women screened by ages 35 and 45, and 90% of women with pre-cancer or invasive cancer receiving appropriate treatment.“

World Health Organization – WHO (Cervical cancer)

1-Screening is looking for cancer before a person has any symptoms. This can help find cancer at an early stage. When abnormal tissue or cancer is found early, it may be easier to treat. By the time symptoms appear, cancer may have begun to spread.

Know this about screening:

Scientists are trying to better understand which people are more likely to get certain types of cancer.

Cervical dysplasia occurs more often in women who are in their 20s and 30s. Death from cervical cancer is rare in women younger than 30 years and in women of any age who have regular screenings with the Pap test. The Pap test is used to detect cancer and changes that may lead to cancer. The chance of death from cervical cancer increases with age. In recent years, deaths from cervical cancer have been slightly higher in Black women younger than 50 years than in White women younger than 50 years. Deaths from cervical cancer are almost twice as likely in Black women older than 60 years than in White women older than 60 years.

Human papillomavirus (HPV) infection is the major risk factor for cervical cancer.

2.If cervical cancer is suspected, your doctor is likely to start with a thorough examination of your cervix. A special magnifying instrument (colposcope) is used to check for abnormal cells.

During the colposcopic examination, your doctor is likely to take a sample of cervical cells (biopsy) for laboratory testing. To obtain tissue, your doctor may use:

• Punch biopsy, which involves using a sharp tool to pinch off small samples of cervical tissue.
• Endocervical curettage, which uses a small, spoon-shaped instrument (curet) or a thin brush to scrape a tissue sample from the cervix

If the punch biopsy or endocervical curettage is worrisome, your doctor may perform one of the following tests:

• Electrical wire loop, which uses a thin, low-voltage electrified wire to obtain a small tissue sample. Generally this is done under local anesthesia in the office.
• Cone biopsy (conization), which is a procedure that allows your doctor to obtain deeper layers of cervical cells for laboratory testing. A cone biopsy may be done in a hospital under general anesthesia.

Staging the cervical cancer:

Cervical Cancer. Carcinoma of Cervix. Malignant neoplasm arising from cells in the cervix uteri. Vaginal bleeding. Vector diagram

If your doctor determines that you have cervical cancer, you’ll have further tests to determine the extent (stage) of your cancer. Your cancer’s stage is a key factor in deciding on your treatment.

Staging exams include:

• Imaging tests. Tests such as X-ray, CT, MRI and positron emission tomography (PET) help your doctor determine whether your cancer has spread beyond your cervix.
• Visual examination of your bladder and rectum. Your doctor may use special scopes to see inside your bladder and rectum.

“The American Cancer Society’s estimates for cervical cancer in the United States for 2025 are:

• About 13,360 new cases of invasive cervical cancer will be diagnosed.
• About 4,320 women will die from cervical cancer.

Cervical precancers are diagnosed far more often than invasive cervical cancer.

Cervical cancer is most frequently diagnosed in women between the ages of 35 and 64, with the average age being 50. It rarely develops in women younger than 20.

Many older women don’t realize that they are still at risk of developing cervical cancer as they age. More than 20% of cervical cancers are found in women over 65. However, these cancers rarely occur in women who have been getting regular tests to screen for cervical cancer before they were 65.

Cervical cancer incidence rates decreased by more than half from the mid-1970s to the mid-2000s, largely because of the increased use of screening, but they have stabilized over the past decade. In women ages 30 to 44, however, rates have increased 1.7% each year from 2012 to 2019.

In contrast, rates declined 11% each year for women ages 20 to 24.”

American Cancer Society (Cervical Cancer Statistics | Key Facts About Cervical Cancer | American Cancer Society)

Cervical Cancer. Carcinoma of Cervix. Malignant neoplasm arising from cells in the cervix uteri. Vaginal bleeding. Vector diagram

Cervical cancer risk factors

GENERAL

• Pregnancy: Women who have had three or more full-term pregnancies, or who had their first full-term pregnancy before age 17, are twice as likely to get cervical cancer.

GENETICS

• Family history: Women with a sister or mother who had cervical cancer are two to three times more likely to develop cervical cancer.

LIFESTYLE

• Sexual history: Certain types of sexual behavior are considered risk factors for cervical cancer and HPV infection. These include: sex before age 18, sex with multiple partners and sex with someone who has had multiple partners. Studies also show a link between chlamydia infection and cervical cancer.
• Smoking: A woman who smokes doubles her risk of cervical cancer.
• Oral contraceptive use: Women who take oral contraceptives for more than five years have an increased risk of cervical cancer, but this risk returns to normal within a few years after the pills are stopped.

OTHER CONDITIONS

• Weakened immune system: In most people with healthy immune systems, the HPV virus clears itself from the body within 12-18 months. However, people with HIV or other health conditions or who take medications that limit the body’s ability to fight off infection have a higher risk of developing cervical cancer.
• Diethylstilbestrol (DES): Women whose mothers took DES, a drug given to some women to prevent miscarriage between 1940 and 1971, have a higher risk of developing cervical cancer.
• HPV: Though HPV causes cancer, having HPV does not mean you will get cancer. The majority of women who contract HPV clear the virus or have treatment so the abnormal cells are removed. HPV is a skin infection, spread through skin-to-skin contact with a person who has the virus.

Additional facts about HPV:

• There are more than 100 types of HPV, 30-40 of which are sexually transmitted.
• Of these, at least 15 are high-risk HPV strains that can cause cervical cancer. The others cause no symptoms or genital warts.
• Up to 80 percent of women will contract HPV in their lifetime. Men get HPV, too, but there is no test for them.
• A healthy immune system will usually clear the HPV virus before there is a symptom, including the high-risk types of HPV.
• Only a small percentage of women with high-risk HPV develop cervical cancer.

Understanding risk factors:

Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer. Not having risk factors doesn’t mean that you will not get cancer. If you think you may be at risk, you should discuss it with your doctor.

Regarding symptoms of cervical cancer:

In most cases, cervical cancer does not cause noticeable symptoms in the early stages of the disease. Routine Pap screening is important to check for abnormal cells in the cervix, so they can be monitored and treated as early as possible. Most women are advised to get a Pap test starting at age 21.

The Pap test is one of the most reliable and effective cancer screening methods available, and women should have yearly exams by an OB-GYN. However, the Pap test may not detect some cases of abnormal cells in the cervix. The HPV test screens women for the high-risk HPV strains that may lead to cervical cancer. It is approved for women over age 30.

Although screening methods are not 100 percent accurate, these tests are often an effective method for detecting cervical cancer in the early stages when it is still highly treatable. Talk with your doctor about which type of cervical cancer screening is right for you.

When present, common symptoms of cervical cancer may include:

• Vaginal bleeding: This includes bleeding between periods, after sexual intercourse or post-menopausal bleeding.
• Unusual vaginal discharge: A watery, pink or foul-smelling discharge is common.
• Pelvic pain: Pain during intercourse or at other times may be a sign of abnormal changes to the cervix, or less serious conditions.

All of these cervical cancer symptoms should be discussed with your doctor.

Signs of advanced stages of cervical cancer:

Cervical cancer may spread (metastasize) within the pelvis, to the lymph nodes or elsewhere in the body. Signs of advanced cervical cancer include:

• Weight loss
• Fatigue
• Back pain
• Leg pain or swelling
• Leakage of urine or feces from the vagina
• Bone fractures

“The two most important things you can do to prevent cervical cancer are to get the HPV vaccine if you are eligible, and to be tested regularly according to American Cancer Society (ACS) guidelines. These can be found in The American Cancer Society Guidelines for the Prevention and Early Detection of Cervical Cancer.

The most common form of cervical cancer starts with pre-cancerous changes and there are ways to stop this from developing. The first way is to find and treat pre-cancers before they become invasive cancers, and the second is to prevent the pre-cancers.”

American Cancer Society (Can Cervical Cancer Be Prevented | Ways to Prevent Cervical Cancer | American Cancer Society)