“Psoriasis effects more than 3 percent of the U.S. adults (your looking at 900,000 adults roughly).”.

National Psoriasis Foundation

“The age at which Spinal Muscular Atrophy-SMA symptoms begin roughly correlates with the degree to which motor function is affected: The earlier the age of onset, the greater the impact on motor function.  SMA involves the loss of nerve cells called motor neurons in the spinal cord and is classified as a motor neuron disease.In the most common form of SMA (chromosome 5 SMA, or SMN-related SMA), there is wide variability in age of onset, symptoms, and rate of progression. On Dec. 23, 2016, the U.S. Food and Drug Administration (FDA) approved Spinraza (nusinersen) for the treatment of SMA. Spinraza is designed to treat the underlying defect in SMA, which means it potentially may be effective at slowing, stopping, or perhaps reversing the symptoms of SMA.”

MDA Muscular Dystrophy Association

“If your wondering what is the difference between muscular atrophy and dystrophy here is the key; the difference between atrophy and dystrophy is that atrophy is a disorder that causes partial or complete wasting away of a part of the body and decrease in size of a cell, organ or tissue, while dystrophy is a group of disorders that causes weakness in the tissues in the body and leads to reduced mobility.”

MAYO CLINIC

The most common form of muscular dystrophy – Duchenne muscular dystrophy – typically affects young boys, but other variations can strike in adulthood.

Currently, there is no cure for muscular dystrophy, but certain physical and medical treatments can improve symptoms and slow the disease’s progression.

is a group of diseases that make muscles weaker and less flexible over time. It is caused by a problem in the genes that control how the body keeps muscles healthy. For some people, the disease starts early in childhood. Others don’t have any symptoms until they are teenagers or middle-aged adults.

How muscular dystrophy affects you or your child depends on the kind. Most people’s condition will get worse over time, and some people may lose the ability to walk, talk, or care for themselves. But that doesn’t happen to everyone. Other people can live for many years with mild symptoms.

There are more than 30 kinds of muscular dystrophy, and each is different based on:

• The genes that cause it
• The muscles it affects
• The age when symptoms first appear
• How quickly the disease gets worse

People usually get one of nine major forms of the disease:

• Duchenne muscular dystrophy (DMD) is the most common form. It mainly affects boys, and starts between ages 3 and 5.
• Becker muscular dystrophy is like Duchenne, except milder. It also affects boys but the symptoms start later — between ages 11 and 25.
• Myotonic muscular dystrophy is the most common form in adults. People who have it can’t relax their muscles after they contract. It can affect both men and women, and it usually starts when people are in their 20s.
• Congenital muscular dystrophy starts at birth or shortly afterwards.
• Limb-Girdle muscular dystrophy often starts in a person’s teens or 20s.
• Facioscapulohumeral muscular dystrophy affects the muscles of the face, shoulders, and upper arms. It can affect anyone from teenagers to adults in their 40s.
• Distal muscular dystrophy affects the muscles of the arms, legs, hands, and feet. It usually comes on later in life, between ages 40 and 60.
• Oculopharyngeal muscular dystrophy starts in a person’s 40s or 50s. It causes weakness in the muscles of the face, neck, and shoulders, and droopy eyelids (ptosis), followed by difficulty swallowing (dysphagia).
• Emery-Dreifuss muscular dystrophy affects mainly boys, usually starting around age 10. People with this form often have heart problems along with muscle weakness.

Stayed tune for part III this weekend!

“SMA is the leading genetic cause of death in infancy, and it is estimated that 1 in 50 Americans is a gene carrier; and early detection and treatment are key to improving long-term health outcomes for people with SMA.”

Michigan.gov

“As the weather gets warmer, we tend to spend more time outside under the hot sun. It’s important to know the difference between heat stroke and heat exhaustion.]

Both heat stroke and heat exhaustion are caused by your body’s inability to cool itself.

Sweat is your body’s natural tool for cooling you down. If you overexercise or work strenuously in hot weather or a heated room, your body may have difficulty producing enough sweat to keep you cool.

Heat exhaustion occurs when the body loses excess amounts of water and salt, typically from sweating. On the other hand, heat stroke is a serious medical emergency that occurs when your body is unable to control its internal temperature.”.

Healthline (healthline.com)

Heatstroke is a condition caused by your body overheating, usually as a result of prolonged exposure to or physical exertion in high temperatures. This most serious form of heat injury, heatstroke, can occur if your body temperature rises to 104 F (40 C) or higher. The condition is most common in the summer months.

Heatstroke requires emergency treatment. Untreated heatstroke can quickly damage your brain, heart, kidneys and muscles. The damage worsens the longer treatment is delayed, increasing your risk of serious complications or death.

Heatstroke can occur as a result of:

• Exposure to a hot environment. In a type of heatstroke, called nonexertional (classic) heatstroke, being in a hot environment leads to a rise in core body temperature. This type of heatstroke typically occurs after exposure to hot, humid weather, especially for prolonged periods. It occurs most often in older adults and in people with chronic illness.
• Strenuous activity. Exertional heatstroke is caused by an increase in core body temperature brought on by intense physical activity in hot weather. Anyone exercising or working in hot weather can get exertional heatstroke, but it’s most likely to occur if you’re not used to high temperatures.

In either type of heatstroke, your condition can be brought on by:

• Wearing excess clothing that prevents sweat from evaporating easily and cooling your body
• Drinking alcohol, which can affect your body’s ability to regulate your temperature
• Becoming dehydrated by not drinking enough water to replenish fluids lost through sweating

Heatstroke signs and symptoms include:

• High body temperature. A core body temperature of 104 F (40 C) or higher, obtained with a rectal thermometer, is the main sign of heatstroke.
• Altered mental state or behavior. Confusion, agitation, slurred speech, irritability, delirium, seizures and coma can all result from heatstroke.
• Alteration in sweating. In heatstroke brought on by hot weather, your skin will feel hot and dry to the touch. However, in heatstroke brought on by strenuous exercise, your skin may feel dry or slightly moist.
• Nausea and vomiting. You may feel sick to your stomach or vomit.
• Flushed skin. Your skin may turn red as your body temperature increases.
• Rapid breathing. Your breathing may become rapid and shallow.
• Racing heart rate. Your pulse may significantly increase because heat stress places a tremendous burden on your heart to help cool your body.
• Headache. Your head may throb.

Risk factors

Anyone can develop heatstroke, but several factors increase your risk:

• Age. Your ability to cope with extreme heat depends on the strength of your central nervous system. In the very young, the central nervous system is not fully developed, and in adults over 65, the central nervous system begins to deteriorate, which makes your body less able to cope with changes in body temperature. Both age groups usually have difficulty remaining hydrated, which also increases risk.
• Exertion in hot weather. Military training and participating in sports, such as football or long-distance running events, in hot weather are among the situations that can lead to heatstroke.
• Sudden exposure to hot weather. You may be more susceptible to heat-related illness if you’re exposed to a sudden increase in temperature, such as during an early-summer heat wave or travel to a hotter climate.Limit activity for at least several days to allow yourself to acclimate to the change. However, you may still have an increased risk of heatstroke until you’ve experienced several weeks of higher temperatures.
• A lack of air conditioning. Fans may make you feel better, but during sustained hot weather, air conditioning is the most effective way to cool down and lower humidity.
• Certain medications. Some medications affect your body’s ability to stay hydrated and respond to heat. Be especially careful in hot weather if you take medications that narrow your blood vessels (vasoconstrictors), regulate your blood pressure by blocking adrenaline (beta blockers), rid your body of sodium and water (diuretics), or reduce psychiatric symptoms (antidepressants or antipsychotics).Stimulants for attention-deficit/hyperactivity disorder (ADHD) and illegal stimulants such as amphetamines and cocaine also make you more vulnerable to heatstroke.
• Certain health conditions. Certain chronic illnesses, such as heart or lung disease, might increase your risk of heatstroke. So can being obese, being sedentary and having a history of previous heatstroke.

Complications

Heatstroke can result in a number of complications, depending on how long the body temperature is high. Severe complications include:

• Vital organ damage. Without a quick response to lower body temperature, heatstroke can cause your brain or other vital organs to swell, possibly resulting in permanent damage.
• Death. Without prompt and adequate treatment, heatstroke can be fatal.

When to go to the doctor or call 911:

If you think a person may be experiencing heatstroke, seek immediate medical help. Call 911 or your local emergency services number.

Take immediate action to cool the overheated person while waiting for emergency treatment.

• Get the person into shade or indoors.
• Remove excess clothing.
• Cool the person with whatever means available — put in a cool tub of water or a cool shower, spray with a garden hose, sponge with cool water, fan while misting with cool water, or place ice packs or cold, wet towels on the person’s head, neck, armpits and groin.

• Without prompt and adequate treatment, heatstroke can be fatal.

Prevention

Heatstroke is predictable and preventable. Take these steps to prevent heatstroke during hot weather:

• Wear loosefitting, lightweight clothing. Wearing excess clothing or clothing that fits tightly won’t allow your body to cool properly.
• Protect against sunburn. Sunburn affects your body’s ability to cool itself, so protect yourself outdoors with a wide-brimmed hat and sunglasses and use a broad-spectrum sunscreen with an SPF of at least 15. Apply sunscreen generously, and reapply every two hours — or more often if you’re swimming or sweating.
• Drink plenty of fluids. Staying hydrated will help your body sweat and maintain a normal body temperature
• Never leave anyone in a parked car. This is a common cause of heat-related deaths in children. When parked in the sun, the temperature in your car can rise 20 degrees F (more than 11 C) in 10 minutes.It’s not safe to leave a person in a parked car in warm or hot weather, even if the windows are cracked or the car is in shade. When your car is parked, keep it locked to prevent a child from getting inside.
• Take it easy during the hottest parts of the day. If you can’t avoid strenuous activity in hot weather, drink fluids and rest frequently in a cool spot. Try to schedule exercise or physical labor for cooler parts of the day, such as early morning or evening.
• Get acclimated. Limit time spent working or exercising in heat until you’re conditioned to it. People who are not used to hot weather are especially susceptible to heat-related illness. It can take several weeks for your body to adjust to hot weather.
• Be cautious if you’re at increased risk. If you take medications or have a condition that increases your risk of heat-related problems, avoid the heat and act quickly if you notice symptoms of overheating. If you participate in a strenuous sporting event or activity in hot weather, make sure there are medical services available in case of a heat emergency.

“Poliomyelitis (polio) is a highly infectious viral disease that largely affects children under 5 years of age. The virus is transmitted by person-to-person spread mainly through the faecal-oral route or, less frequently, by a common vehicle (e.g. contaminated water or food) and multiplies in the intestine, from where it can invade the nervous system and cause paralysis.

In 1988, the World Health Assembly adopted a resolution for the worldwide eradication of polio, marking the launch of the Global Polio Eradication Initiative, spearheaded by national governments, WHO, Rotary International, the US Centers for Disease Control and Prevention (CDC), UNICEF, and later joined by the Bill & Melinda Gates Foundation and Gavi, the Vaccine Alliance. Wild poliovirus cases have decreased by over 99% since 1988, from an estimated 350 000 cases in more than 125 endemic countries then to 175reported cases in 2019.

Of the 3 strains of wild poliovirus (type 1, type 2 and type 3), wild poliovirus type 2 was eradicated in 1999 and no case of wild poliovirus type 3 has been found since the last reported case in Nigeria in November 2012. Both strains have officially been certified as globally eradicated. As at 2020, wild poliovirus type 1 affects two countries: Pakistan and Afghanistan.”

WHO World Health Organization

“Polio, or poliomyelitis, is a disabling and life-threatening disease caused by the poliovirus.  The virus spreads from per son to person and can infect a person’s spinal cord, causing paralysis (can’t move parts of the body). Most people who get infected with poliovirus (about 72 out of 100) will not have any visible symptoms.  About 1 out of 4 people (or 25 out of 100) with poliovirus infection will have flu-like symptoms.  A smaller proportion of people (much less than one out of 100, or 1-5 out of 1000) with poliovirus infection will develop other, more serious symptoms that affect the brain and spinal cord.  This would include Paresthesia (feeling of pins and needles in the legs), others with Meningitis (infection of the covering of the spinal cord and/or brain) occurs in about 1 out of 25 people with poliovirus infection to Paralysis=the worst symptom (can’t move parts of the body) or weakness in the arms, legs, or both, occurs in about 1 out of 200 people with poliovirus infectionl.”

CDC Centers for Disease Control and Prevention