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Part II Gastrointestinal Diseases – Continuation on types of GI diseases and how to prevent or deal with a GI problem!

Other perianal infections

Sometimes the skin glands near your anus become infected and need to be drained, like in this structural disease. Just behind the anus, abscesses can form that contain a small tuft of hair at the back of the pelvis (called a pilonidal cyst).

Sexually transmitted diseases that can affect the anus include anal warts, herpes, AIDS, chlamydia and gonorrhea.

Diverticular disease

The structural disease diverticulosis is the presence of small outpouchings (diverticula) in the muscular wall of your large intestine that form in weakened areas of the bowel. They usually occur in the sigmoid colon, the high-pressure area of the lower large intestine.

Diverticular disease is very common and occurs in 10% of people over age 40 and in 50% of people over age 60 in Western cultures. It is often caused by too little roughage (fiber) in the diet. Diverticulosis can sometimes develop/progress into diverticulitis

Complications of diverticular disease happen in about 10% of people with outpouchings. They include infection or inflammation (diverticulitis), bleeding and obstruction. Treatment of diverticulitis includes treating the constipation and sometimes antibiotics if really severe. Surgery is needed as last resort in those who have significant complications to remove the involved diseased segment of the colon.

Colon polyps and cancer

Each year, 130,000 Americans are diagnosed with colorectal cancer, the second most common form of cancer in the United States. Fortunately, with advances in early detection and treatment, colorectal cancer is one of the most curable forms of the disease. By using a variety of screening tests, it is possible to prevent, detect and treat the disease long before symptoms appear.

The importance of screening

Almost all colorectal cancers begin as polyps, benign (non-cancerous) growths in the tissues lining your colon and rectum. Cancer develops when these polyps grow and abnormal cells develop and start to invade surrounding tissue. Removal of polyps can prevent the development of colorectal cancer. Almost all precancerous polyps can be removed painlessly using a flexible lighted tube called a colonoscope. If not caught in the early stages, colorectal cancer can spread throughout the body. More advanced cancer requires more complicated surgical techniques.

Most early forms of colorectal cancer do not cause symptoms, which makes screening especially important. When symptoms do occur, the cancer might already be quite advanced. Symptoms include blood on or mixed in with the stool, a change in normal bowel habits, narrowing of the stool, abdominal pain, weight loss, or constant tiredness.

Most cases of colorectal cancer are detected in one of four ways:

  • By screening people at average risk for colorectal cancer beginning at age 45.
  • By screening people at higher risk for colorectal cancer (for example, those with a family history or a personal history of colon polyps or cancer).
  • By investigating the bowel in patients with symptoms.
  • A chance finding at a routine check-up.

Early detection is the best chance for a cure.

Colitis

There are several types of colitis, which are conditions that cause an inflammation of the bowel. These include:

  • Infectious colitis.
  • Ulcerative colitis (cause unknown).
  • Crohn’s disease (cause unknown).
  • Ischemic colitis (caused by not enough blood going to the colon).
  • Radiation colitis (after radiotherapy).

Colitis causes diarrhea, rectal bleeding, abdominal cramps and urgency (frequent and immediate need to empty the bowels). Treatment depends on the diagnosis, which is made by colonoscopy and biopsy.

Prevention:

Can gastrointestinal diseases be prevented?

Many diseases of the colon and rectum can be prevented or minimized by maintaining a healthy lifestyle, practicing good bowel habits and getting screened for cancer.

A colonoscopy is recommended for average-risk patients at age 45. If you have a family history of colorectal cancer or polyps, a colonoscopy may be recommended at a younger age. Typically, a colonoscopy is recommended 10 years younger than the affected family member. (For example, if your brother was diagnosed with colorectal cancer or polyps at age 45, you should begin screening at age 35.)

If you have symptoms of colorectal cancer you should consult your healthcare provider right away. Common symptoms include:

  • A change in normal bowel habits.
  • Blood on or in the stool that is either bright or dark.
  • Unusual abdominal or gas pains.
  • Very narrow stool.
  • A feeling that the bowel has not emptied completely after passing stool.
  • Unexplained weight loss.
  • Fatigue.
  • Anemia (low blood count).

Other types of gastrointestinal diseases

There are many other gastrointestinal diseases. Some are discussed, but others are not covered here. Other functional and structural diseases include peptic ulcer disease, gastritis, gastroenteritis, celiac disease, Crohn’s disease, gallstones, fecal incontinence, lactose intolerance, Hirschsprung disease, abdominal adhesions, Barrett’s esophagus, appendicitis, indigestion (dyspepsia), intestinal pseudo-obstruction, pancreatitis, short bowel syndrome, Whipple’s disease, Zollinger-Ellison syndrome, malabsorption syndromes and hepatitis.

QUOTE FOR FRIDAY:

“The digestive system is a complicated and diverse part of the body. It extends from the mouth to the rectum.

  • The primary function of the digestive system is to eliminate waste and assist the body in absorbing essential nutrients and minerals.
  • Studies report that the gut plays a crucial role in immunity.

Every one of us has experienced digestive issues, such as stomach pain, indigestion, or discomfort, at some point in our lives for various reasons.

The medical community classifies all diseases that affect the GI tract as digestive diseases. Unfortunately, more than 85 percent of all adult Americans have some form of intestinal disorder.

The best chance for a cure is always early detection. Many GI disturbances and disorders can be avoided or reduced by leading a healthy lifestyle and undergoing regular screening as recommended.”

Medicine Net (What Are 13 Common Diseases of the Digestive System?)

QUOTE FOR THURSDAY:

“What is the home Epley maneuver?

The home Epley maneuver is a type of exercise help that helps to treat the symptoms of benign paroxysmal positional vertigo (BPPV). You can do this exercise at home.

BPPV is caused by a problem in your inner ear. Your semicircular canals are found inside your ear. They detect motion and send this information to your brain. The utricle is a nearby part of the ear. It contains calcium crystals (canaliths) that help it detect movement.

Sometimes these crystals detach from the utricle and end up inside the semicircular canals. When these crystals move inside the canals, they may send incorrect signals to your brain about your position. This can make you feel like the world is spinning. This is called vertigo.

Dr. John Epley designed a series of movements to dislodge the crystals from the semicircular canals. These movements bring the crystals back to the utricle, where they belong. This treats the symptoms of vertigo.

The original Epley maneuver was designed to be done with a healthcare provider. The home Epley maneuver is similar. These are a series of movements that you can do without help, in your own home.”

John Hopkins Medicine (Home Epley Maneuver | Johns Hopkins Medicine)

Part 3 Benign Posterior Paroxsymal Vertigo – Surgeries for it and hospital with high ratings in this area.

 

Surgical Procedures for Vestibular Dysfunction When is surgery necessary? 

When medical treatment isn’t effective in controlling vertigo and other symptoms caused by vestibular system dysfunction, surgery may be considered. The type of surgery performed depends upon each individual’s diagnosis and physical condition. Surgical procedures for peripheral vestibular disorders are either corrective or destructive. The goal of corrective surgery is to repair or stabilize inner ear function. The goal of destructive surgery is to stop the production of sensory information or prevent its transmission from the inner ear to the brain.  The types of surgeries used if non-invasive treatments are not successful are possibly: 

Labyrinthectomy:

A labyrinthectomy is a destructive procedure used for Ménière’s disease. The balance end organs are removed so that the brain no longer receives signals from the parts of the inner ear that sense gravity and motion changes. The hearing organ (cochlea) is also sacrificed with this procedure.

Vestibular nerve section:

A vestibular nerve section is a destructive procedure used for Ménière’s disease. The vestibular branch of the vestibulo-cochlear nerve is cut in one ear to stop the flow of balance information from that ear to the brain. The brain can then compensate for the loss by using only the opposite ear to maintain balance.

Chemical labyrinthectomy:

A chemical labyrinthectomy is also known as transtympanic or intratympanic treatment or gentamicin infusion. This is a destructive procedure used for Ménière’s disease. An antibiotic called gentamicin is introduced into the middle ear and absorbed via the round window. The drug destroys the vestibular hair cells so that they cannot send signals to the brain.

Endolymphatic sac decompression:

Endolymphatic sac decompression is a stabilizing procedure sometimes used for Ménière’s disease or secondary endolymphatic hydrops to relieve endolymphatic pressure in the cochlea and vestibular system. A variety of techniques exist. One method involves allowing the sac to decompress by removing the mastoid bone surrounding it. Other methods involve inserting a shunt (a tube or strip) into the endolymphatic sac so that, theoretically, excess fluid can drain out into the mastoid cavity or other location. The effectiveness of decompression techniques in controlling vertigo remains in doubt.

Oval or round window plugging:

If the exercises described above are ineffective in controlling symptoms, symptoms have persisted for a year or longer,  and the diagnosis is very clear, a surgical procedure called “posterior canal plugging” may be recommended. Canal plugging blocks most of the posterior canal’s function without affecting the functions of the other canals or parts of the ear. This procedure poses a substantial risk to hearing — ranging from 3-20%, but is effective in about 85-90% of individuals who have had no response to any other treatment (Shaia et al, 2006; Ahmed et al, 2012). The risk of the surgery to hearing derives from inadvertent breaking into the endolymphatic compartment while attempting to open the bony labyrinth with a drill. Sensibly, canal plugging for BPPV (note the first letter stands for “benign”) is rarely undertaken these days due to the risk to hearing.

Alternatives to plugging:

Singular nerve section is the main alternative. Dr Gacek (Syracuse, New York) has written extensively about singular nerve section (Gacek et al, 1995). Interestingly, Dr. Gacek is the only surgeon who has published any results with this procedure post 1993 (Leveque et al, 2007). Singular nerve section is very difficult because it can be hard to find the nerve.

Dr. Anthony (Houston, Texas), advocates laser assisted posterior canal plugging.  It seems to us that these procedures, which require unusual amounts of surgical skill, have little advantage over a conventional canal plugging procedure.  Oval or round window plugging is a stabilizing procedure sometimes used for repair of perilymph fistulas. Openings in the oval and/or round windows are patched with tissue taken from the external ear or from behind the ear so that perilymph fluid does not leak through the fistulas.

 Pneumatic equalization (PE) tubes:

Pneumatic equalization (PE) is a stabilizing procedure sometimes used for treating perilymph fistulas. A tube is inserted through the tympanic membrane (eardrum) with one end in the ear canal and the other in the middle ear, to equalize the air pressure on the two sides of the eardrum.

Canal partitioning (canal plugging):

Canal partitioning is a stabilizing procedure sometimes used for treating BPPV or superior semicircular canal dehiscence. The problematic semicircular canal is partitioned or plugged with small bone chips and human fibrinogen glue to stop the movement of endolymph and foreign particles within the canal so that it no longer sends false signals to the brain.

Microvascular decompression:

Microvascular decompression is performed to relieve abnormal pressure of the vascular loop (blood vessel) on the vestibulo-cochlear nerve.

Stapedectomy:

Stapedectomy is a stabilizing procedure sometimes used for otosclerosis. It is accomplished by replacing the stapes bone with a prosthesis.

Acoustic neuroma (vestibular schwannoma): 

This procedure involves the removal of a noncancerous tumor that grows from the tissue of the vestibular branch of the vestibulo-cochlear nerve.

Cholesteatoma removal:

This procedure involves the removal of a skin growth that starts in the middle ear and that can secrete enzymes that destroy bone and surrounding structures.

Ultrasound surgery:

Ultrasound is applied to the ear to destroy the balance end organs so that the brain no longer receives signals from the parts of the ear that sense gravity and motion changes. Cochlear dialysis Cochlear dialysis is a stabilizing procedure sometimes used to promote movement of excess fluid out of the inner ear by filling the scala tympani with a chemical solution.

Thanks to NYU Medical Hospital in Manhattan, NY you can Click here to download the “Surgery for Peripheral Vestibular Disorders” publication. – See more at: http://vestibular.org/understanding-vestibular-disorders/treatment/vestibular-surgery#sthash.GDeNWxjl.dpuf.

If you have this problem and need a great hospital than let us look at the ranking of hospitals:

Of all 180 hospitals in the New York, New York metropolitan area, the 53 listed below are the top-ranking. This metro area, also called NYC, includes Long Island, Westchester County, and northern New Jersey. I know if I had a problem that I could not get rid of immediately with a antibiotic simple cure I would next want to go to the best if my county’s hospital couldn’t remove the problem completely. So here through “US News and World Report” via the internet they show the following information on the best hospitals in NYC and Northern NJ: (Look below or to the next page)

These are their rankings on Columbia Presbyterian and NYU, NATIONALLY, in the following categories:

Starting with the best is Columbia Presbyterian in NY, for those in NY, as your #1 choice:

Adult Specialties

This hospital was among 144 facilities—roughly 3 percent of the 4,743 analyzed for the latest Best Hospitals rankings—to be ranked in even one of the 16 specialties 2024.

COLUMBIA PRESBYTERIAN RATINGS:

Nationally Ranked
High-Performing

 

NYU HOSPITAL RATINGS:

Gynecology

Rank in This Specialty #NA
Overall Score in This Specialty 66.8 / 100

For further checking of hospitals go to http://health.usnews.com/best-hospitals/area/ny/new-york-presbyterian-university-hospital-of-columbia-and-cornell-6210024 since hospitals do change yearly in their scores and this is the most recent.

QUOTE FOR WEDNESDAY:

“Benign paroxysmal positional vertigo (BPPV) is a common inner ear disorder. BPPV isn’t a sign of a serious problem, and it usually disappears on its own within a few days of the first episode. (It could take several weeks for some people.) However, the symptoms of BPPV can be very frightening and may be dangerous, especially in adults over the age of 65. The unsteadiness of BPPV can lead to falls, which are a leading cause of fractures.

Benign paroxysmal positional vertigo is the most common inner ear disorder. In fact, approximately 20% of people who are evaluated for dizziness are diagnosed with BPPV.  BPPV usually goes away on its own. However, until it’s successfully treated, it can come back. In some cases, months — or even years — go by before another episode occurs.  BPPV is almost always triggered by a change in your head’s position. Some people may notice symptoms when lying down or sitting up in bed. Others might notice symptoms when they tilt their head back or to the side. These symptoms often worsen with age due to normal wear and tear of the inner ear structures.”

Cleveland Clinic (Benign Paroxysmal Positional Vertigo (BPPV): Treatment, Symptoms & Causes)

 

QUOTE FOR TUESDAY:

“Benign paroxysmal positional vertigo (BPPV) is one of the most common causes of vertigo — the sudden sensation that you’re spinning or that the inside of your head is spinning.

BPPV causes brief episodes of mild to intense dizziness. It is usually triggered by specific changes in your head’s position. This might occur when you tip your head up or down, when you lie down, or when you turn over or sit up in bed.

Although BPPV can be bothersome, it’s rarely serious except when it increases the chance of falls. You can receive effective treatment for BPPV depending on the intensity!”

MAYO CLINIC (Benign paroxysmal positional vertigo (BPPV) – Symptoms and causes – Mayo Clinic)

QUOTE FOR MONDAY:

“Many people enjoy living and working in cultivated greenspaces, and most like having beautiful plants around. But is there more to it? Here are seven benefits science says indoor plants may provide.

1. Indoor plants may help reduce stress levels

A studyTrusted Source published in the Journal of Physiological Anthropology found that plants in your home or office can make you feel more comfortable, soothed, and natural.

In the study, participants were given two different tasks: repotting a houseplant or completing a short computer-based task. After each task, researchers measured the biological factors associated with stress, including heart rate and blood pressure.

They found that the indoor gardening task lowered the stress response in participants. The computer task, on the other hand, caused a spike in heart rate and blood pressure, even though the study participants were young men well-accustomed to computerized work.

Researchers concluded that working with plants could reduce both physiological and psychological stress.

2. Real plants may sharpen your attention

Sorry, plastic plants won’t help you pass your exams. In a small study involving 23 participants, researchers put students in a classroom with either a fake plant, a real one, a photograph of a plant, or no plant at all.

Brain scans of the participants showed that the students who studied with real, live plants in the classroom were more attentive and better able to concentrate than students in the other groups.

3. Working with plants can be therapeutic

For people experiencing the symptoms of mental illness, indoor gardening can be helpful.

ResearchersTrusted Source have used horticultural therapy to increase feelings of well-being among people with depression, anxiety, dementia, and other conditions.

Although horticultural therapy has been around for centuries, it has found a modern expression: Medical clinics in Manchester, England are now “prescribing” potted plants to patients with depression or anxiety symptoms.

4. Plants may help you recover from illness faster

Being able to look at plants and flowers may speed your recovery from an illness, injury, or surgery.

A 2002 review of the research revealed that people recuperating from several kinds of surgery needed less pain medication and had shorter hospital stays than people who weren’t looking at greenery during their recovery periods.

It’s important to note that most research focuses on plants and natural scenery in hospital settings rather than at home.

5. Plants may boost your productivity

A bromeliad may turn out to be the best cubicle-mate you’ve ever had.

Multiple studies have found that plants in the workspace increase both productivity and creativity. One frequently cited study from 1996 found that students in a campus computer lab worked 12 percent faster and were less stressed when plants were placed nearby.

In a 2004 studyTrusted Source, researchers challenged people to make creative word associations. They performed better when a plant was in the room with them.

And a 2007 study showed that people with more plants in their workspace took fewer sick days and were more productive on the job.

6. Plants may improve your whole outlook on work

A view of the city park might improve anyone’s job satisfaction — but it might surprise you to learn that a potted plant could have a similar effect.

ResearchersTrusted Source interviewed over 440 Amazon employees in India and the United States. They found that those whose office environment included natural elements like indoor plants felt greater job satisfaction and more commitment to the organization than those who didn’t work around natural elements.

Researchers said the natural elements helped to buffer the effects of job stress and anxiety.

7. Plants may improve the quality of indoor air

Scientific support for phytoremediation — that’s the word for plants scrubbing contaminants from the air — usually begins with a NASA study conducted in the 1980s.

Researchers then were looking for ways to improve the air quality in a sealed spacecraft, and they concluded that the roots and soil of houseplants reduced airborne volatile organic compounds (VOCs) significantly.

Since those early studies, researchers have both confirmed those findings and called them into questionTrusted Source.

Recent findings suggest that you’d have to shelter a large number of plants to equal the air purifying efficiency of modern biofilters and other technologies.

If you do decide to purchase houseplants to freshen the air naturally, these are several of the species shownTrusted Source to be most effective:

  • areca, lady, dwarf date, and bamboo palms
  • Boston fern
  • rubber tree
  • spider plant
  • Ficus tree”

Healthline (7 Science-Backed Benefits of Indoor Plants)

Part II Learn types of Plants & how they can enhance our lives both physically and mentally!

plants enhance our lives (Arab.Thaliana) Part II  plants can enhance our lives (Arab.Thaliana Part II)

Part II

Look at medical proof, going back as far July 2011 by online publication of Nature, investigated why Arabidopsis does its major stem-growing in the dark—a pattern common to most plants. Biologist Steve Kay and colleagues at the University of California, San Diego, report that a specific trio of proteins regulates the rhythm in Arabidopsis stems. Arabidopsis thaliana helped scientists not very long ago too unearth new clues about the daily cycles of many organisms, including humans. This is the latest in a long line of research, much of it supported by the National Institutes of Health, that uses plants to solve puzzles in human health. While other model organisms may seem to have more in common with us, greens like Arabidopsis provide an important view into genetics, cell division and especially light sensing, which drives 24-hour behavioral cycles called circadian rhythms.

Some human cells, including cancer cells, divide with a 24-hour rhythm. One of the main human circadian rhythm genes, cryptochrome, has been associated with diabetes and depression. Both of these discoveries grew from work with plants.

  plants enhance our lives.png1 (Arabidopsis Thaliana) Part II                                                                                                                                         The Arabidopsis Thaliana Plant

Arabidopsis (rockcress) is a genus in the family Brassicaceae. They are small flowering plants related to cabbage and mustard, and can be used similarly to other mustard greens, in salads or sautéed, but its use as an edible spring green is not widely noted. Arabidopsis thaliana is a small dicotyledonous species being a member of the Brassicaceae or mustard family. Although closely related to such economically important crop plants as turnip, cabbage, broccoli, and canola, Arabidopsis is not an economically important plant. Despite this, it has been the focus of intense genetic, biochemical and physiological study for over 40 years because of several traits that make it very desirable for laboratory study. As a photosynthetic organism, Arabidopsis requires only light, air, water and a few minerals to complete its life cycle. It has a fast life cycle, produces numerous self progeny, has very limited space requirements, and is easily grown in a greenhouse or indoor growth chamber. It possesses a relatively small, genetically tractable genome that can be manipulated through genetic engineering more easily and rapidly than any other plant genome.

T group of proteins, called the evening complex, interacts in the early evening to silence two genes that usually promote plant growth. When the evening complex’s activity trails off a few hours before dawn, proteins release the brakes on growth and plants enter their nightly phase of rapid stem elongation.

The plant has been mutated in the three genes that code for the evening complex, they noticed that this made the Arabidopsis biological clock run out of sync—stems grew unusually long and flowered early.

Scientists aren’t yet certain why night is the best time for stems to grow, it has to do with using resources efficiently. Plants pick up carbon and nitrogen during the day, then store these essential nutrients as starch and proteins. In the later night, they can release these resources in a coordinated fashion to provide the building blocks for stem growth it has been said.

Our understanding of human health and the role of clocks in health and disease can greatly benefit from studying how clocks work in plants.

Scientists are interested in answering basic biological questions, but others who work with plants have their eyes on future disease therapies. Plant-based molecules, for instance, are being used to target reservoirs of HIV that hide out in their hosts. At the University of California, Berkeley, chemist Jay Keasling has been looking over the years for simple ways to get microbes to produce greater quantities of these plant-based molecules at lower cost.

How plants like Arabidopsis suppress harmful genes may also help improve HIV therapies. A team of biologists that had been led by Craig Pikaard at Washington University in St. Louis is investigating RNA polymerases, chemicals important in determining which genes get switched on, to learn how plants silence harmful virus-derived genes. Similar silencing pathways could be harnessed for HIV therapies.

More generally, scientists are looking toward plants as a medicinal source. Chemist Sarah O’Connor at MIT has genetically engineered periwinkle plants, the natural source of the anticancer drug vinblastine, to produce variations of the drug with halogens attached. Halogens make some medicines last longer in the body, meaning that probing periwinkle’s capabilities could make cancer treatments more effective.

Plant compounds present in carrots and parsley may one day support more effective delivery of chemotherapy treatments, new research has found. Specific plant compounds are able to inhibit transport mechanisms in the body that select what compounds are absorbed into the body, and eventually into cells. These same transport mechanisms are known to interfere with cancer chemotherapy treatment.

Some further examples of good compounds coming from plants for human lives are:

Flavonoids are one class of secondary plant metabolites that are also known as Vitamin P or citrin. These metabolites are mostly used in plants to produce yellow and other pigments which play a big role in coloring the plants. In addition, Flavonoids are readily ingested by humans and they seem to display important anti-inflammatory, anti-allergic and anti-cancer activities. Flavonoids are also found to be powerful anti-oxidants and researchers are looking into their ability to prevent cancer and cardiovascular diseases. Flavonoids help prevent cancer by inducing certain mechanisms that may help to kill cancer cells, and researches believe that when the body processes extra flavonoid compounds, it triggers specific enzymes that fight carcinogens. Good dietary sources of Flavonoids are all citrus fruits, which contain the specific flavanoids hesperidins, quercitrin, rutin, berries, tea, dark chocolate and red wine that includes many of the health benefits attributed to these foods come from the Flavonoids they contain.

Phytic acid is the main method of phosphorus storage in plant seeds, but is not readily absorbed by many animals (only absorbed by ruminant animals). Not only is phytic acid a phosphorus storage unit, but it also is a source of energy and cations, a natural antioxidant for plants, and can be a source of mycoinositol which is one of the preliminary pieces for cell walls.

Phytic acid is also known to bond with many different minerals, and by doing so prevents those minerals from being absorbed; making phytic acid an anti-nutrient. There is a lot of concern with phytic acids in nuts and seeds because of its anti-nutrient characteristics. In preparing foods with high phytic acid concentrations, it is recommended they be soaked in after being ground to increase the surface area. Soaking allows the seed to undergo germination which increases the availability of vitamins and nutrient, while reducing phytic acid and protease inhibitors ultimately increasing the nutritional value. Cooking can also reduce the amount of phytic acid in food but soaking is much more effective.

Phytic acid is an antioxidant found in plant cells that most likely serves the purpose of preservation. This preservation is removed when soaked, reducing the phytic acid and allowing the germination and growth of the seed.

Atropine is a type of secondary metabolite called a tropane alkaloid.

Alkaloids contain nitrogens, frequently in a ring structure, and are derived from amino acids. Tropane is an organic compound containing nitrogen and it is from tropane that atropine is derived from. Atropine is synthesized by a reaction between tropine and tropate, catalyzed by atropinase. Within Atropa belladonna atropine synthesis has been found to take place primarily in the root of the plant. The concentration of synthetic sites within the plant is indicative of the nature of secondary metabolites.

Gossypol has a yellow pigment and is found in cotton plants. It occurs mainly in the root and/or seeds of different species of cotton plants.  Gossypol can have various chemical structures. It can exist in three forms: gossypol, gossypol acetic acid, and gossypol formic acid. All of these forms have very similar biological properties. Gossypol is a type of aldehyde, meaning that it has a formyl group. The formation of gossypol occurs through an isoprenoid pathway. Isoprenoid pathways are common among secondary metabolites.  3Gossypol’s main function in the cotton plant is to act as an enzyme inhibitor. An example of gossypol’s enzyme inhibition is its ability to inhibit nicotinamide adenine dinucleotide-linked enzymes of Trypanosoma cruzi. Trypanosoma cruzi is a parasite which causes Chaga’s disease.

For some time it was believed that gossypol was merely a waste product produced during the processing of cottonseed products. Extensive studies have shown that gossypol has other functions. Many of the more popular studies on gossypol discuss how it can act as a male contraceptive. Gossypol has also been linked to causing hypokalemic paralysis. Hypokalemic paralysis is a disease characterized by muscle weakness or paralysis with a matching fall in potassium levels in the blood. Hypokalemic paralysis associated with gossypol in-take usually occurs in March, when vegetables are in short supply, and in September, when people are sweating a lot. This side effect of gossypol in-take is very rare however. Gossypol induced hypokalemic paralysis is easily treatable with potassium repletion.

Believe or not, plants enhanced our lives.

Part II Awareness of Spinal Muscular Atrophy (SMA)-What are the symptoms and the what are the types of SMA!

Symptoms of muscle atrophy

You may have muscle atrophy if:

  • One of your arms or legs is noticeably smaller than the other.
  • You are experiencing marked weakness in one limb.
  • You have been physically inactive for a very long time.

Contact your doctor to have a complete medical examination if you believe you may have muscle atrophy or if you are unable to move normally. You may have an undiagnosed condition that requires treatment. Your doctor will be able to provide you with diet and exercise options.

S/S of Spinal Muscular Atrophy (SMA):

Symptoms of SMA may include:

  • muscle weakness and decreased muscle tone
  • limited mobility
  • breathing problems-Remember we say  the weakness tends to be more severe in the muscles that are close to the center of the body (proximal) compared to muscles away from the body’s center (distal).   So your respiratory muscles are close to the center.
  • problems eating and swallowing
  • delayed gross motor skills
  • spontaneous tongue movements
  • scoliosis (curvature of the spine)

At birth, infants may appear normal, but can develop some of these signs as they age 6 mths or 18mths and 3,4,6 (it all depends on what stage level they are in since the stages happen at different ages, discussed after the s/s:

  • Muscle weakness and hypotonia
  • Areflexia
  • Impaired head control
  • Reduced bulbar function, including impaired swallowing, feeding, and weak cry and cough
  • Tongue fasciculations
  • Paradoxical breathing, also known as “belly breathing,” and bell-shaped chest due to intercostal muscle weakness
  • Progressive respiratory failure requiring noninvasive ventilation (NIV)
  • Missed motor milestones

Spinal Muscular Atrophy (SMA)-WHEN S/S start?

All signs snd symptoms depends on the type of Spinal Muscular Atrophy you are diagnosed with.

TYPES OF SMA:

There are five subtypes of SMA. Healthcare providers classify them based on the age of onset, as well as the severity and life expectancy. The subtypes include:

  • SMA type 0 (congenital SMA): This is a rare subtype that affects a fetus before birth. Pre-birth, there are typically decreased fetal movements. At birth, infants with type 0 have severe muscle weakness and typically go into respiratory failure. Death usually happens at birth or within the first month of life.
  • SMA type 1 (severe SMA): About 60% of SMA cases are type 1 — also called Werdnig-Hoffman disease. Symptoms arise within the first six months of life and include limited head control and decreased muscle tone (hypotonia). Infants with type 1 SMA also have difficulty swallowing and breathing. Without breathing support, children with type 1 SMA die before their second birthday.
  • SMA type 2 (intermediate SMA): Symptoms of type 2 SMA (also called Dubowitz disease) appear between six months and 18 months of life. Symptoms include hypotonia and worsening muscle weakness, which tends to affect their legs more than their arms. Children with type 2 SMA may be able to sit up but can’t walk. Around 70% of people with type 2 will survive until 25, with some surviving into their 30s. Respiratory issues are the major cause of death.
  • SMA type 3 (mild): Symptoms of type 3 SMA (also called Kugelbert-Welander disease) appear after a child’s first 18 months of life. Type 3 symptoms include lower limb muscle weakness, leading to difficulty walking. People with type 3 MSA don’t tend to develop breathing issues, and it typically doesn’t affect life expectancy.
  • SMA type 4 (adult): This is the mildest form of SMA. It doesn’t typically appear until after the age of 21. Muscle weakness symptoms progress slowly, so most people with type 4 remain mobile. It typically doesn’t affect life expectancy.

Updated 8/06/2025

 

 

QUOTE FOR THE WEEKEND:

“Specifically, the researchers found that people who surround themselves with plant life and other forms of natural beauty, indoors and out, experience emotional and mental health benefits that have a positive impact on their social, psychological, physical, cognitive, environmental, and spiritual well-being, These benefits include:

1. Stress reduction. Spending time in natural settings helps speed up recovery from mental fatigue, slow down heart rate, reduce high blood pressure, and lower anxiety.

2. Reduced symptoms of depression. Researchers repeatedly report increases in subjects’ mood, fewer incidents of depressive symptoms, as well as increased memory span and decreased symptoms of anxiety after a walk in nature, as compared to a walk through an urban environment. One Korean study of patients diagnosed with moderate to severe depression compared the effects of cognitive-behavioral therapy (CBT) performed in a hospital to CBT performed in an arboretum with a forest-like setting. Symptoms of depression were most significantly reduced in the arboretum group, who also experienced 20% to 30% higher rates of complete remission when compared to a typically medicated group.

3. Stronger memory retention. Compared to those who walked through a well-trafficked urban area, participants in several studies who walked through a green space or a natural environment, such as an arboretum, were better able to focus and concentrate on a test of their working memory.

4. Fewer symptoms of post-traumatic stress. Studies of both veterans and victims of natural disasters who participated in horticultural therapies or nature-based rehabilitation programs found that both groups were better able to control symptoms of PTSD and developed more positive states of mind.

5. Improved symptoms of attention-deficient disorders (ADD/ADHD). In one study, school children diagnosed with ADHD were better able to concentrate after a walk in a park than their peers who went for a walk in a downtown neighborhood. Similar studies found that even short nature breaks are restorative and can improve attention span, working memory and cognitive functioning in children with ADD/ADHD.”

Psychology Today (11 Ways Plants Enhance Your Mental and Emotional Health | Psychology Today)