A history of infectious mononucleosis due to infection by Epstein–Barr virus (EBV) may increase risk of Hodgkin’s Lymphoma but the precise contribution of Epstein–Barr virus remains largely unknown.  Hodgkin lymphoma is characterized by the orderly spread of disease from one lymph node group to another and by the development of systemic symptoms with advanced disease. When Hodgkins cells are examined microscopically, multinucleated Reed–Sternberg cells (RS cells) are the characteristic histopathologic finding.

Memorial Sloan Kettering Hospital

Hodgkin’s lymphoma — formerly known as Hodgkin’s disease — is a cancer of the lymphatic system, which is part of your immune system.

In Hodgkin’s lymphoma, cells in the lymphatic system grow abnormally and may spread beyond the lymphatic system. As Hodgkin’s lymphoma progresses, it compromises your body’s ability to fight infection.

Hodgkin’s lymphoma is one of two common types of cancers of the lymphatic system. The other type, non-Hodgkin’s lymphoma, is far more common.

Advances in diagnosis and treatment of Hodgkin’s lymphoma have helped give people with this diagnosis the chance for a full recovery. The prognosis continues to improve for people with Hodgkin’s lymphoma.

Hodgkin’s lymphoma signs and symptoms may include:

• Painless swelling of lymph nodes in your neck, armpits or groin
• Persistent fatigue
• Fever and chills
• Night sweats
• Unexplained weight loss — as much as 10 percent or more of your body weight
• Loss of appetite
• Itching
• Increased sensitivity to the effects of alcohol or pain in your lymph nodes after drinking alcoholMake an appointment with your doctor if you have any signs or symptoms that worry you.Doctors know that most Hodgkin’s lymphoma occurs when an infection-fighting cell called a B cell develops a mutation in its DNA. The mutation tells the cells to divide rapidly and to continue living when a healthy cell would die. The mutation causes a large number of oversized, abnormal B cells to accumulate in the lymphatic system, where they crowd out healthy cells and cause the signs and symptoms of Hodgkin’s lymphoma.Classical Hodgkin’s lymphomaSubtypes of classical Hodgkin’s lymphoma include:
• Classical Hodgkin’s lymphoma is the more common type of this disease. It can be broken down further into subtypes. People diagnosed with classical Hodgkin’s lymphoma have large, abnormal cells called Reed-Sternberg cells in their lymph nodes.
• Various types of Hodgkin’s lymphoma exist. The type is based on the types of cells involved in your disease and their behavior. Your type determines your treatment options.
• It’s not clear what causes Hodgkin’s lymphoma.
• When to see a doctor

• Nodular sclerosis Hodgkin’s lymphoma
• Mixed cellularity Hodgkin’s lymphoma
• Lymphocyte-depleted Hodgkin’s lymphoma
• Lymphocyte-rich classical Hodgkin’s lymphomaThis much rarer type of Hodgkin’s lymphoma involves large, abnormal cells that are sometimes called popcorn cells because of their appearance. Treatment may be different from the classical type. People with this type of Hodgkin’s lymphoma may have a better chance of a cure when the disease is diagnosed at an early stage.Factors that increase the risk of Hodgkin’s lymphoma include:
• Lymphocyte-predominant Hodgkin’s lymphoma

• Your age. Hodgkin’s lymphoma is most often diagnosed in people between the ages of 15 and 30, as well as those older than 55.
• A family history of lymphoma. Having a close family member who has Hodgkin’s lymphoma or non-Hodgkin’s lymphoma increases your risk of developing Hodgkin’s lymphoma.
• Your sex. Males are slightly more likely to develop Hodgkin’s lymphoma.
• Past Epstein-Barr infection. People who have had illnesses caused by the Epstein-Barr virus, such as infectious mononucleosis, are more likely to develop Hodgkin’s lymphoma than are people who haven’t had Epstein-Barr infections.
• A weakened immune system. Having a compromised immune system, such as from HIV/AIDS or from having an organ transplant requiring medications to suppress the immune response, increases the risk of Hodgkin’s lymphoma.
• Make an appointment with your family doctor or a general practitioner if you have any signs or symptoms that worry you. After your diagnosis, your doctor may refer you to a specialist who treats Hodgkin’s lymphoma, such as a hematologist, medical oncologist or radiation oncologist.
• Preparing for an appointment with your doctor

What you can do

• Be aware of any pre-appointment restrictions. At the time you make the appointment, be sure to ask if there’s anything you need to do in advance, such as restrict your diet before testing.
• Write down any symptoms you’re experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.
• Write down key personal information, including any major stresses or recent life changes.
• Make a list of all medications, vitamins or supplements you’re taking.
• Consider taking a family member or friend along. Sometimes it can be difficult to absorb all the information provided during an appointment. Someone who accompanies you may remember something that you missed or forgot.
• Write down questions to ask your doctor.

Your time with your doctor is limited, so preparing a list of questions can help you make the most of your time together.

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over points you want to spend more time on.

TURN INTO PART 2 ON MONDAY (tests, procedures and treatment for the disease).

It is known that hyperinsulinemia precedes type II diabetes and that it is associated with an adverse cardiovascular risk profile.

American Heart Association

 There are several stages involved in the development of heart disease. Unfortunately having too much insulin in your blood is involved in each and every stage.  Without disease that affects your insulin level, like in diabetes, you can help control this through prevention measures in dieting, exercise with balance of resting.

Stage 1: First excessive insulin raises the level of bad cholesterol in the blood – the LDL version. At the same time it decreases the level of “good” cholesterol – the HDL variety. Then it goes on to increase the level of triglycerides in the blood – yet another risk factor for heart disease. Excessive insulin also causes your blood to clot more quickly which increases your risk of stroke. Though your kidneys are not insulin sensitive, when your insulin level is elevated it indirectly causes your kidneys to retain salt and fluid which further increases your blood pressure.

Stage 2: In this stage excessive insulin increases cellular proliferation which damages the lining of your blood vessels. This increases the blood vessels vulnerability and sets the stage for even more blood vessel damage.

Stage 3: In this third stage insulin plays a different role. There are two very different kinds of LDL cholesterol. “Pattern A” LDL cholesterol is light, floats on water and represents no particular threat to the human body. But “Pattern B” LDL is a smaller particle, much more dense form that’s intimately involved in the heart disease process. That’s because it’s this denser form that attaches itself to the blood vessel lining to form artery-clogging plaques. Excessive insulin increases this more dangerous form of LDL. It’s this kind of LDL that forms the “fatty streak” plaques that are the hallmark of early heart disease.

Stage 4: Excessive insulin promotes the conversion of specialized cells called microphages in your blood into foam cells which further promotes the formation of dangerous plaques.

Stage 5: Before the plaque becomes dangerous it must be oxidized by free radicals. Once again insulin plays a role by increasing the level of dangerous tissue-damaging free radicals in your blood. The smaller dense LDL particles that excessive insulin promotes are more subject to free radical oxidation.

Stage 6: This damage to your blood vessel lining triggers an inflammatory response which contributes to the vicious cycle. Excessive insulin boosts inflammation throughout the body including within the lining of blood vessels. Many medical researchers feel that inflammation plays a major role in heart disease and excessive insulin plays a major role in generating it. In addition, studies have shown that this increased level of inflammation can directly damage brain neurons. (The C-reactive blood test measures the level of inflammation in your body. Today more and more doctors are using the test in recognition of the key role inflammation plays in so many different diseases.)

Stage 7: As the plaque builds over the years, it eventually restricts the flow of blood causing either chest pain or other symptoms in other parts of your body. If the blood vessels feeding the brain become restricted, your brain function will inevitably be affected. In numerous studies where insulin was injected into the blood vessels of lab animals, it was found that thick artery clogging plaques accumulated just downstream from the injection sites.

Stage 8: Excessive insulin also directly stimulates the central nervous system raising blood pressure which further increases the risk of a heart attack or stroke. At this stage you may experience TIAs (transient  ischemic attacks) which are small strokes that damage small areas of your brain. Damage caused by TIAs are commonly found in the brains of deceased Alzheimer’s patients.

Stage 9: Excessive insulin causes the body to increase it’s excretion of magnesium which causes a magnesium deficiency which can then trigger arterial spasms that can directly cause a heart attack. If a heart attack doesn’t get you, remember that excessive insulin has already increased the blood’s tendency to clot. A blood clot can easily form at the site of the spasm and travel to other areas of the body such as the lungs where it can cause a fatal embolism.

Stage 10: You’re officially diagnosed as having heart disease and if that isn’t bad enough this diagnosis dramatically increases your risk of dementia and premature death.

After reading the above it should come as no shock that studies have found that fatal heart attacks are three times more likely after a high carbohydrate meal than after a high fat/protein meal!

During an angioplasty in OR for a blockage , the balloon is inflated and the spring-like stent expands and locks into place inside the artery tring to break up the blockage.  If their are too many blockages or its unsuccessful a stent is put in place.  The stent stays in the artery permanently to hold it open and improve blood flow to your heart.

MAYO CLINIC

A stent is a wire mesh tube that is used to help hold open an artery. To simple understanding this concept think of a plumber or a mechanic. With a plumber sometimes they have to replace a certain area of a pipe that connects the water or like a mechanic replacing a certain area of piping (like the muffler piping connected infront of the muffler than can either can be replaced or just welded with piece of piping welded just to save money. Well a stent opens the artery that was clogged and its put in that place to reinforce that area of the artery to remain open to allow blood to get to that heart from that coronary artery and it will stay there life to keep the artery permanently patent to prevent the blockage from happening again with the synthetic mesh piece.

Description

Stents are used to hold open diseased coronary arteries (these arteries supply blood to the heart), as well as diseased arteries of the peripheral vascular system (PVS). Peripheral means away from the heart the PVS is the arteries that supply blood to the rest of the body (again away from the heart all the way down to the hands and feet).

There are variety of stents currently available.

For a surgeon to find out if you even need one, first usually a angiogram is performed and this is a catheter simply from the femerol artery or from your arm to the coronary arteries. If the MD sees you show a blockage 80% or more an angioplasty is performed which is a balloon at the end of this catheter that blows up and decompresses to give the effect like punching gloves. The balloon inflates and deflates over and over again till the blockage breaks open free and then a stent is put in that area to help keep it open permanently (patent).

Some stents have been compressed onto the outside of an angioplasty balloon catheter and delivered by inflating the balloon in the desired location. Other stents are “self- expanding” spring-loaded devices, which expand automatically upon deployment.

Stents remain in arteries permanently. The tissue lining the arteries actually grows over the metal mesh to cover the inner lumen of the stent.

Stent procedures have become very common like tonsillectomies were in childhood. Stents are sometimes used as an alternative to coronary artery bypass surgery, if the patient is a candidate. Stents are often used in combination with balloon angioplasty. One leads to the other depending on what the angioplasty displays for the surgeon on the T.V. in when they are doing the procedure and if the come up to a blockage high enough to perform the angioplasty followed with a stent it will be done.

Stents are used in cases of “restenosis”, which refers to the re-closing of arteries after balloon angioplasty. In carefully selected patients, the use of stents can dramatically reduce restenosis following balloon angioplasty or other catheter-based procedures. Stents are used frequently to hold open the arteries that have been damaged, torn, or dissected by balloon angioplasty or other catheter-based procedures. Like plumber or mechanic, get it.

Stents allow angioplasty to be done in patients with severe and long-segment obstruction of coronary arteries. As soon as the I initial part of the block is widened, a stent is place, which holds it open allowing further opening to proceed. Stents have also allowed angioplasty to be performed in patients with blocks of multiple vessels, and in multiple blocks in a single artery.

Risks

Risks include the standard risks of an interventional, catheter-based procedure, which should be specifically discussed with your doctor. Lesions treated with stents can “restenosis” (re- narrow with in weeks to months after the procedure) similar to restenosis associated with angioplasty. This is why patients after having a stent put in they are on a medication for example like Plavix for life to prevent this occurrence from happening. It is a anti platelet medication, meaning it doesn’t allow clotting to happen in the stent so blockage doesn’t reoccur through clotting.

Many new technologies are being tested to reduce the problem of restenosis. These technologies include coating and coverings for the stent, new materials, and radiation. These new technologies are primarily experimental at this point and will reach soon to the market if not already. Technology allows the medical field to continuously expand and this will be replaced at one point but isn’t yet. Just give it time. At one point we had no CABG (coronary artery bypass) but now the stent in certain cases is replaced by angiograms to further expanding to angioplasties and stents furthering allowing the surgery to take place 1x hopefully if the patient is compliant in diet, exercise, and following the doctors orders with meds, activity and follow up visits (which are so vital).   A lot is up to the patient in caring or themselves to prevent having this take place again.

Follow up Instructions

Your doctor will recommend blood thinning medications following your stent procedure. These agents are usually given for one month post procedure along with aspirin and then continued indefinitely. Your doctor may also prescribe antibiotics for a period of time after the stent procedure, to be taken anytime you have a medical or dental procedure. Preventing infection.

MRI tests should not be done for at least eight weeks without your doctor’s approval. Metal detectors do not present a problem. Stents appear to be safe in the long-term; there are no long-term complications associated with a permanent stent.

A recent study has shown that babies with dogs are actually healthier than those without dogs, reporting fewer coughs, runny noses, and ear infections. The reason, researchers believe, is because dogs will track in dirt, mud, and other germ-infested bits of earth, thereby boosting the child’s immune system.

Jason Iannone (journalist, author)

Goldsmiths College released a study that showed more dogs will approach someone who’s crying or in distress than someone who is not. This shows that dogs are empathetic and are eager to help comfort humans in pain.

Their sense of smell can do even more than we think; dogs can also detect low blood sugar in their master. They will either alert the person that the sugar has dropped or, if a diabetic attack has already occurred, will bark and bark and bark in an attempt to alert somebody to come help, thus working to save the diabetic’s life.

Some dogs are also able to detect seizures in humans. Recent research has shown certain dogs are able to warn seizure patients that they’re going to experience an attack, sometimes hours before it happens. Nobody yet knows how they do it, or why only certain dogs can do it. They also can’t be trained to do it, so if you feel you need a seizure-sniffing dog, you need to make sure you have yourself a natural.

Due to their incredible sense of smell, dogs have shown anywhere from 70 to 99% accuracy (depending on the study) when tasked with detecting lung cancer in a nearby patient.

Fibromyalgia is a debilitating disease that can leave its victim in constant pain. Studies have shown that the Xolo dog’s body temperature can be used as a kind of therapeutic heating pad, due to it being a hairless species. Of course, unlike heating pads, a Xolo will bond with you, snuggle with you and keep you warm as long as you need, leading to both external comfort and internal happiness.

In a surprising twist, it might actually be beneficial to get a dog for your baby, even if they’re allergic. Studies have shown that children under the age of one who live with a dog are much less likely to develop the chronic, and annoying, skin condition called eczema.

Dogs can highly make humans more social. The British Medical Journal has concluded that dogs act as “social catalysts,” who help people get out more, approach others more easily, and overall reduce isolation. This is actually just as important as the basic companionship that dogs provide, as human social support is beneficial to human health and the dog.

Simply by being themselves, dogs have been shown to help reduce PTSD among soldiers. In addition to providing the usual doggie companionship, they have been shown to help sufferers come out of their shells, be less numb and angry, and improve their social life as well.

A dog kissing you obviously feels wonderful, but it might actually have physical benefits too. Studies have shown that saliva, both the human and doggie variety, can help stimulate nerves and muscles, and get oxygen moving again, which is the secret ingredient in helping wounds to heal. In short, “licking your wounds” is not just a cliché after all.

Almost certainly due to the positive vibes and good feelings that dogs bring out of their masters, even in the worst of times, studies have found that older people who own dogs average at least one less doctor appointment per year than those who do not.

Not that they are the cure but preliminary studies by the American Heart Association are revealing that dog owners have less risk of heart disease than those without dogs. The reasons given are the exercise that owners get when walking their dogs, plus the presence of the dog helps the owner deal with stress better. The evidence is mostly anecdotal right now, but dog owners know that it’s all true.

Day-to-day depression, or even more serious chronic depression, is easier to handle with the love of a dog, studies show. Simply by having them around, and knowing that even at our worst, somebody loves us unconditionally and is eager to see us happy again, we’re given a reason to get up and keep going.

Autistic children often find the world very stressful, in ways that the non-autistic can’t understand. Luckily, a dog can. Studies are showing that bringing a therapy dog into an autistic household helps to reduce the amount of cortisol (a stress hormone) in the autistic child’s body. This both calms the child down and shows him that he has a friend.

Bullying has been a huge problem for a long time, and people are finally doing something about it. Dogs, too. Experimental programs have been launched that bring dogs into schools to promote empathy, with the lesson that you shouldn’t treat people badly, because you wouldn’t do it to a dog. Thus far, kids have been able to make the connection, which will hopefully continue to be the case.

Dogs have shown that they can help keep dementia sufferers on schedule, reminding them when its time for medicine and when to see the doctor. In addition, when the owner experiences frustration over the state of their mind, the “dementia dog” is right there to support them, comfort them, and remind them that someone’s always there for them.

AREN’T DOGS AMAZING!!

“Childhood abuse and neglect can profoundly effect adult relationships, causing anxiety, abandonment issues and intense emotions and that these may cause frustration for both parties.”

Elaine Bing, a counseling psychologist in Pretoria who specializes in trauma, relationships and the effects of abuse.

You were born preprogrammed to bond with one very significant person—your primary caregiver, probably your mother. Like all infants, you were a bundle of emotions—intensely experiencing fear, anger, sadness, and joy. The emotional attachment that grew between you and your caregiver was the first interactive relationship of your life, and it depended upon nonverbal communication. The bonding you experienced determined how you would relate to other people throughout your life, because it established the foundation for all verbal and nonverbal communication in your future relationships.

Individuals who experience confusing, frightening, or broken emotional communications during their infancy often grow into adults who have difficulty understanding their own emotions and the feelings of others. This limits their ability to build or maintain successful relationships. Attachment—the relationship between infants and their primary caregivers—is responsible for:

• shaping the success or failure of future intimate relationships
• the ability to maintain emotional balance
• the ability to enjoy being ourselves and to find satisfaction in being with others
• the ability to rebound from disappointment, discouragement, and misfortune

Scientific study of the brain—and the role attachment plays in shaping it—has given us a new basis for understanding why vast numbers of people have great difficulty communicating with the most important individuals in their work and love lives. Once, we could only use guesswork to try and determine why important relationships never evolved, developed chronic problems, or fell apart. Now, thanks to new insights into brain development, we can understand what it takes to help build and nurture productive and meaningful relationships at home and at work.

Whether it turns out good or bad, the infant brain is profoundly influenced by the attachment bond—a baby’s first love relationship. When the primary caretaker can manage personal stress, calm the infant, communicate through emotion, share joy, and forgive easily, the young child’s nervous system becomes “securely attached.” The strong foundation of a secure attachment bond enables the child to be self-confident, trusting, hopeful, and comfortable in the face of conflict. As an adult, he or she will be flexible, creative, hopeful, and optimistic.

Our secure attachment bond shapes our abilities to:

• feel safe
• develop meaningful connections with others
• explore our world
• deal with stress
• balance emotions
• experience comfort and security
• make sense of our lives
• create positive memories and expectations of relationships

Attachment bonds are as unique as we are. Primary caretakers don’t have to be perfect. They do not have to always be in tune with their infants’ emotions, but it helps if they are emotionally available for the  majority of the time.

The powerful, life-altering lessons we learn from our attachment bond—our first love relationship—continue to teach us as adults. The gut-level knowledge we gained then guides us in improving our adult relationships and making them secure.

Lesson No. 1—adult relationships depend for their success on nonverbal forms of communication. Newborn infants cannot talk, reason or plan, yet they are equipped to make sure their needs are met. Infants don’t know what they need, they feel what they need, and communicate accordingly. When an infant communicates with a caretaker who understands and meets their physical and emotional needs, something wonderful occurs.

Relationships in which the parties are tuned in to each other’s emotions are called attuned relationships, and attuned relationships teach us that:

• nonverbal cues deeply impact our love relationships
• play helps us smooth over the rough spots in love relationships
• conflicts can build trust if we approach them without fear or a need to punish

When we can recognize knee-jerk memories, expectations, attitudes, assumptions and behaviors as problems resulting from insecure attachment bonds, we can end their influence on our adult relationships. That recognition allows us to reconstruct the healthy nonverbal communication skills that produce an attuned attachment and successful relationships.