“Von Willebrand disease (VWD) is a genetic disorder caused by missing or defective von Willebrand factor (VWF), a clotting protein. VWF binds factor VIII, a key clotting protein, and platelets in blood vessel walls, which help form a platelet plug during the clotting process.  Von Willebrand disease is a lifelong bleeding disorder in which your blood doesn’t clot well=Bleeding.”

MAYO Clinic