Depression Vs. Anger — What does it all mean and What do I do?

Getting the blues  or down in the dumps now and than in one thing but staying in the blues or down in the dumps just sinking deeper over a long period of time can be diagnosed as clinical depression. Clinical depression presents many forms and symptoms. It is not something just to be brushed off, assuming it will rectify itself in a while. One of the most common symptoms noted when a person suffers from clinical depression is anger. Whether it’s uncontrollable anger toward oneself or outward aggression toward others, it’s clinically proven that depression and anger run hand in hand.

Do you find yourself feeling angry more often than usual, or more often than not, depression could be to blame. Anger is a common symptom of depression, which can lurk beneath the surface of any man, woman, or child as well.

Depressive disorders come in many different types, but each type has its own unique symptoms and treatments. Major depression, the most common type of a depressive disorder, is characterized by a combination of symptoms (see symptom list) that interfere with the ability to work, study, sleep, eat, and enjoy once pleasurable activities. Such a disabling episode of depression may occur only once but more commonly occurs several times in a lifetime. Mental health professionals use this checklist of specific symptoms to determine whether major depression exists or not. Depression is also rated by your diagnosing physician or mental health professional in terms of its severity — mild, moderate, or severe. Severe depression is the most serious type. A less severe type of depression, dysthymia, involves long-term, chronic symptoms that do not disable, but keep one from functioning well or from feeling good. Many people with dysthymia also experience major depressive episodes at some time in their lives. Another type of depression is experienced as a part of bipolar disorder, also called manic-depressive illness. Not nearly as prevalent as other forms of depressive disorders, bipolar disorder is characterized by cycling mood changes: severe highs (mania) and lows (depression). Sometimes the mood switches are dramatic and rapid, but most often they are gradual. When in the depressed cycle, an individual can have any or all of the symptoms of a depressive disorder. When in the manic cycle, the individual may be overactive, overtalkative, and have a great deal of energy. Mania often affects thinking, judgment, and social behavior in ways that cause serious problems and embarrassment. For example, the individual in a manic phase may feel elated, full of grand schemes that might range from unwise business decisions to romantic sprees

Risk Factors

Numerous risk factors can lead to feelings of depression and anger in an individual. Some of these risk factors include but are not limited to: loneliness, financial strain, unemployment, alcohol or drug abuse, marital or family problems, or lack of a social support network. Depression and anger can also be influenced by childhood trauma, or it can be hereditary.

Symptoms

Anger manifested with depression is no ordinary anger. It can be all-consuming feelings of anger and hatred against one’s self, others or the situation that is causing the depression. One of the first signs of depression in a teenager may be a sudden onset of uncontrollable anger. In turn, constant feelings of anger can also trigger a response of depression. Also noted with depression are a tendency to turn away from family and friends, poor performance at work or school, lack of motivation, feelings of guilt, insomnia and hopelessness

Symptoms of Depression

Not everyone who is depressed or manic experiences every symptom. Some people experience a few symptoms, some many. Severity of symptoms varies with individuals and also varies over time.

Depression

• Persistent sad, anxious, or “empty” mood
• Feelings of hopelessness, pessimism
• Feelings of guilt, worthlessness, helplessness
• Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex
• Decreased energy, fatigue, being “slowed down”
• Difficulty concentrating, remembering, or making decisions
• Insomnia, early-morning awakening, or oversleeping
• Appetite and/or weight loss or overeating and weight gain
• Thoughts of death or suicide; suicide attempts
• Restlessness, irritability
• Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic painMania
• Symptoms of Mania (for Bipolar Disorder)

• Abnormal or excessive elation
• Unusual irritability
• Decreased need for sleep
• Grandiose notions
• Increased talking
• Racing thoughts
• Increased sexual desire
• Markedly increased energy
• Poor judgment
• Inappropriate social behavior

Come back tomorrow for Part 2 on Depression Vs. Anger in Considerations/Treatment and Knowing the Key Factor in what makes us deal with depression, which also can help prevent suicide!!

“Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. Healthy plasma cells help fight infections by making proteins called antibodies. Antibodies find and attack germs.

In multiple myeloma, cancerous plasma cells build up in bone marrow. The bone marrow is the soft matter inside bones where blood cells are made. In the bone marrow, the cancer cells crowd out healthy blood cells. Rather than make helpful antibodies, the cancer cells make proteins that don’t work right. This leads to complications of multiple myeloma.

Multiple myeloma treatment isn’t always needed right away. If the multiple myeloma is slow growing and isn’t causing symptoms, close watching might be the first step. For people with multiple myeloma who need treatment, there are a number of ways to help control the disease.”

MAYO CLINIC (https://www.mayoclinic.org/diseases-conditions/multiple-myeloma/symptoms-causes/syc-20353378)

“An estimated 400,000 people were exposed to toxic contaminants, risk of physical injury, and physically and emotionally stressful conditions in the days, weeks, and months following the attacks. Responders who worked on the rescue, recovery, and relief efforts reported a range of illnesses soon after the attacks. Survivors who lived, worked, and attended school in Lower Manhattan, some who remained throughout and some who returned to their lives in the disaster area, started reporting illnesses as well. estimated 400,000 people were exposed to toxic contaminants, risk of physical injury, and physically and emotionally stressful conditions in the days, weeks, and months following the attacks. Responders who worked on the rescue, recovery, and relief efforts reported a range of illnesses soon after the attacks. Survivors who lived, worked, and attended school in Lower Manhattan, some who remained throughout and some who returned to their lives in the disaster area, started reporting illnesses as well.”

Centers for Disease Control and Prevention – CDC  (https://www.cdc.gov/wtc/exhibition/toxins-and-health-impacts.html)

“If you’ve been diagnosed with cancer, and you aren’t sure about your diagnosis or treatment options, get a second opinion from Cedars-Sinai. Your Virtual Second Opinion will give you the information you need to make the best decisions about your care.  Our hodgkin or  non-hodgkin lymphoma specialists can provide a Virtual Second Opinion in the comfort of your home, and you can get the insights needed to make informed decisions about your care.   Treatments range from chemo, radiation and more.”

Cedars Sinai (https://secondopinion.cedars-sinai.org/department/cancer/?&cid=21046965596&agid=158830926683&tid=kwd-328662390414&kwt=p&adid=691743710360&ext=&dvc=c&loi=&lop=9004281&gclid=EAIaIQobChMI-PzYvvusiAMVFGpHAR3FHQ4aEAAYASAAEgKRwvD_BwE&gclsrc=aw.ds)

Treatments for both Hodgkin’s Lymphoma & Non-Hodgkin’s Lymphoma:

First the doctor needs to know what stage of cancer your in ranging from I to IV.  This shows the doctor the following information to help the M.D. decide what treatment would be most effective to take.

• Stage I. The cancer is limited to one lymph node region or a group of nearby nodes or limited to a single organ.
• Stage II. In this stage, the cancer is in two lymph node regions, or the cancer has invaded one organ and the nearby lymph nodes as well. But the cancer is still limited to a section of the body either above or below the diaphragm.
• Stage III. When the cancer moves to lymph nodes both above and below the diaphragm, it’s considered stage III. Cancer may also be found in the lymph nodes above the diaphragm and in the spleen in non-Hodgkins and may also be in one portion of tissue or an organ near the lymph node groups or in the spleen in Hodgkins.
• Stage IV. This is the most advanced stage of non-Hodgkin’s and Hodgkin’s lymphoma. Cancer cells are in several portions of one or more organs and tissues.
• Stage III. When the cancer moves to lymph nodes both above and below the diaphragm, it’s considered stage III. Cancer may also be in one portion of tissue or an organ near the lymph node groups or in the spleen.
• Stage IV. This is the most advanced stage of Hodgkin’s lymphoma. Cancer cells are in several portions of one or more organs and tissues. Stage IV in both lymphomas affects not only the lymph nodes but also other parts of the body, such as the liver, lungs or bones.
  

Hodgkin Lymphoma Consultation

Which Hodgkin’s lymphoma treatments are right for you depends on the type and stage of your disease, your overall health, and your preferences. The goal of treatment is to destroy as many cancer cells as possible and bring the disease into remission.

Chemotherapy

Chemotherapy is a drug treatment that uses chemicals to kill lymphoma cells. Chemotherapy drugs travel through your bloodstream and can reach nearly all areas of your body.

Chemotherapy is often combined with radiation therapy in people with early-stage classical type Hodgkin’s lymphoma. Radiation therapy is typically done after chemotherapy. In advanced Hodgkin’s lymphoma, chemotherapy may be used alone or combined with radiation therapy.

Chemotherapy drugs can be taken in pill form or through a vein in your arm, or sometimes both methods of administration are used. Several combinations of chemotherapy drugs are used to treat Hodgkin’s lymphoma.

Side effects of chemotherapy depend on the drugs you’re given. Common side effects are nausea and hair loss. Serious long-term complications can occur, such as heart damage, lung damage, fertility problems and other cancers, such as leukemia.

Radiation therapy

Radiation therapy uses high-energy beams, such as X-rays and protons, to kill cancer cells. For classical Hodgkin’s lymphoma, radiation therapy is often used after chemotherapy. People with early-stage nodular lymphocyte-predominant Hodgkin’s lymphoma may undergo radiation therapy alone.

During radiation therapy, you lie on a table and a large machine moves around you, directing the energy beams to specific points on your body. Radiation can be aimed at affected lymph nodes and the nearby area of nodes where the disease might progress. The length of radiation treatment varies, depending on the stage of the disease. A typical treatment plan might have you going to the hospital or clinic five days a week for several weeks. At each visit, you undergo a 30-minute radiation treatment.

Radiation therapy can cause skin redness and hair loss at the site where the radiation is aimed. Many people experience fatigue during radiation therapy. More-serious risks include heart disease, stroke, thyroid problems, infertility and other cancers, such as breast or lung cancer.

Bone marrow transplant

Bone marrow transplant, also known as stem cell transplant, is a treatment to replace your diseased bone marrow with healthy stem cells that help you grow new bone marrow. A bone marrow transplant may be an option if Hodgkin’s lymphoma returns despite treatment.

During a bone marrow transplant, your own blood stem cells are removed, frozen and stored for later use. Next you receive high-dose chemotherapy and radiation therapy to destroy cancerous cells in your body. Finally your stem cells are thawed and injected into your body through your veins. The stem cells help build healthy bone marrow.

People who undergo bone marrow transplant may be at increased risk of infection.

Other drug therapy

Other drugs used to treat Hodgkin’s lymphoma include targeted drugs that focus on specific vulnerabilities in your cancer cells and immunotherapy that works to activate your own immune system to kill the lymphoma cells. If other treatments haven’t helped or if your Hodgkin’s lymphoma returns, your lymphoma cells may be analyzed in a laboratory to look for genetic mutations. Your doctor may recommend treatment with a drug that targets the particular mutations present in your lymphoma cells.

Targeted therapy is an active area of cancer research. New targeted therapy drugs are being studied in clinical trials.

Now look at Non-Hodgkin’s Lymphoma Treatment and look at the similarities of Hodkin’s Lymphoma Rx; both are WBC’s Blood Cancers:

If your non-Hodgkin’s lymphoma is aggressive or causes signs and symptoms, your doctor may recommend treatment. Options may include:

Chemotherapy

Chemotherapy is a drug treatment — given orally or by injection — that kills cancer cells. Chemotherapy drugs can be given alone, in combination with other chemotherapy drugs or combined with other treatments.

Side effects of chemotherapy depend on the drugs you’re given. Common side effects are nausea and hair loss. Serious long-term complications can occur, such as heart damage, lung damage, fertility problems and other cancers, such as leukemia.

Radiation therapy

Radiation therapy uses high-powered energy beams, such as X-rays and protons, to kill cancer cells. During radiation therapy, you’re positioned on a table and a large machine directs radiation at precise points on your body. Radiation therapy can be used alone or in combination with other cancer treatments.

During radiation therapy, you lie on a table and a large machine moves around you, directing the energy beams to specific points on your body. Radiation can be aimed at affected lymph nodes and the nearby area of nodes where the disease might progress. The length of radiation treatment varies, depending on the stage of the disease. A typical treatment plan might have you going to the hospital or clinic five days a week for several weeks, where you undergo a 30-minute radiation treatment at each visit.

Radiation therapy can cause skin redness and hair loss at the site where the radiation is aimed. Many people experience fatigue during radiation therapy. More-serious risks include heart disease, stroke, thyroid problems, infertility, and other cancers, such as breast or lung cancer.

Bone marrow transplant

Bone marrow transplant, also known as a stem cell transplant, involves using high doses of chemotherapy and radiation to suppress your bone marrow. Then healthy bone marrow stem cells from your body or from a donor are infused into your blood where they travel to your bones and rebuild your bone marrow.

People who undergo bone marrow transplant may be at increased risk of infection.

Other drug therapy

Biological therapy drugs help your body’s immune system fight cancer.

For example, one biological therapy called rituximab (Rituxan) is a type of monoclonal antibody that attaches to B cells and makes them more visible to the immune system, which can then attack. Rituximab lowers the number of B cells, including your healthy B cells, but your body produces new healthy B cells to replace these. The cancerous B cells are less likely to recur.

Also, a drug called ibrutinib (Imbruvica) has been approved by the Food and Drug Administration (FDA) for some people undergoing treatment for non-Hodgkin’s lymphoma.

Radioimmunotherapy drugs are made of monoclonal antibodies that carry radioactive isotopes. This allows the antibody to attach to cancer cells and deliver radiation directly to the cells. An example of a radioimmunotherapy drug used to treat non-Hodgkin’s lymphoma is ibritumomab tiuxetan (Zevalin).

Clinical trials

Clinical research studies (clinical trials) may be an option for people whose disease has not been controlled by other treatment options. Ask your doctor about possible clinical trials for your type of non-Hodgkin’s lymphoma.

“The terms Hodgkin and non-Hodgkin lymphoma can be easily confused. Although they’re both named after the scientist who discovered them, they are different diseases that require different treatments to ensure the best results for patients.

Here, lymphoma specialist Paolo Strati, M.D., explains the differences between the two types of lymphoma and shares what newly diagnosed patients should know when seeking treatment.

Non-Hodgkin lymphoma is more common than Hodgkin lymphoma

Non-Hodgkin lymphoma is more common than Hodgkin lymphoma, and both types are slightly more common in men. Although both diseases can be diagnosed at any age, Hodgkin lymphoma is most common in young adults ages 15 to 40 and older adults over age 55. Non-Hodgkin lymphoma is typically diagnosed in adults over age 60.

Some viruses may make you more likely to get both Hodgkin and non-Hodgkin lymphoma. These include: Epstein-Barr virus, human immunodeficiency virus (HIV) and human T-cell lymphocytotropic virus. If you have had any of these viruses, talk with your doctor about whether you might be at increased risk for lymphoma.”

Dr. Anderson’s Cancer Center (https://www.mdanderson.org/cancerwise/hodgkin-vs–non-hodgkin-lymphoma–whats-the-difference.h00-159457689.html)

A particular cell known as the Reed-Sternberg cell is found in the biopsies. This cell is not usually found in other lymphomas, therefore they are called non Hodgkins lymphoma. This may not seem a very big difference, but it is important because the treatment for Hodgkins and non Hodgkins lymphomas can be very different.

Although the diseases may sound similar, there is a lot of difference between Hodgkin and non-Hodgkin lymphoma.

Both Hodgkin and non-Hodgkin lymphoma are malignancies of a family of white blood cells known as lymphocytes, which help the body fight off infections and other diseases.

Both Hodgkin’s lymphoma and non-Hodgkin’s lymphoma are lymphomas — a type of cancer that begins in a subset of white blood cells and these are called lymphocytes. Lymphocytes are an integral part of your immune system, which protects you from germs.

The main difference between Hodgkin’s lymphoma and non-Hodgkin’s lymphoma is in the specific lymphocyte each involves but also it includes:

Sources: National Cancer Institute and Lymphoma Research Foundation 2016

Hodgkin lymphoma is marked by the presence of Reed-Sternberg cells, which are mature B cells that have become malignant, are unusually large, and carry more than one nucleus. The first sign of the disease is often the appearance of enlarged lymph nodes. Non-Hodgkin lymphoma, by contrast, can be derived from B cells or T cells and can arise in the lymph nodes as well as other organs. (B cells and T cells play different roles in the body’s immune response to disease.)

The the Mayo Clinic it states both diseases are relatively rare, but non-Hodgkin lymphoma is more common in the United States, with more than 70,000 new cases diagnosed each year, compared to about 8,000 for Hodgkin lymphoma. The median age of patients with non-Hodgkin lymphoma is 60, but it occurs in all age groups. Hodgkin lymphoma most often occurs in people ages 15 to 24 and in people over 60. There are more than 60 distinct types of non-Hodgkin lymphoma, whereas Hodgkin lymphoma is a more homogeneous disease.

The two forms of lymphoma are marked by a painless swelling of the lymph nodes. Hodgkin lymphomas are more likely to arise in the upper portion of the body (the neck, underarms, or chest). Non-Hodgkin lymphoma can arise in lymph nodes throughout the body, but can also arise in normal organs. Patients with either type can have symptoms such as weight loss, fevers, and night sweats.

The diseases often follow different courses of progression. Hodgkin lymphoma tends to progress in an orderly fashion, moving from one group of lymph nodes to the next, and is often diagnosed before it reaches an advanced stage. Most patients with non-Hodgkin lymphoma are diagnosed at a more advanced stage.

Treatments for lymphoma vary depending on the type of disease, its aggressiveness, and location, along with the age and general health of the patient. As a general rule, however, Hodgkin lymphoma is considered one of the most treatable cancers, with more than 90 percent of patients surviving more than five years. Survival rates for patients with non-Hodgkin lymphoma tend to be lower, but for certain types of the disease, the survival rates are similar to those of patients with Hodgkin lymphoma.

A doctor can tell the difference between Hodgkin’s lymphoma and non-Hodgkin’s lymphoma by examining the cancer cells under a microscope. If in examining the cells, the doctor detects the presence of a specific type of abnormal cell called a Reed-Sternberg cell, the lymphoma is classified as Hodgkin’s. If the Reed-Sternberg cell is not present, the lymphoma is classified as non-Hodgkin’s.

Many subtypes of lymphoma exist, and your doctor will use laboratory tests to examine a sample of your lymphoma cells to determine your specific subtype. Expect to wait a few days to receive results from these specialized tests.

Your type of lymphoma helps your doctor determine your prognosis and your treatment options. The types of lymphoma have very different disease courses and treatment choices, so an accurate diagnosis is an integral part of getting the care you need.

How both Hodgkin’s and Non-Hodgkin’s Disease are diagnosed:

• Physical exam. Your doctor checks for swollen lymph nodes, including in your neck, underarm and groin, as well as for a swollen spleen or liver.
• Blood and urine tests. Blood and urine tests may help rule out an infection or other disease.  A sample of your blood is examined in a lab to see if anything in your blood indicates the possibility of cancer (in both of these diseases particularly the WBCs).
• Imaging tests. Your doctor may recommend imaging tests to look for tumors in your body. Tests may include X-ray, CT, MRI and positron emission tomography (PET).
• Lymph node test. Your doctor may recommend a lymph node biopsy procedure to remove all or part of a lymph node for laboratory testing. Analyzing lymph node tissue in a lab may reveal whether you have non-Hodgkin’s lymphoma and, if so, which type.  Your doctor may recommend a lymph node biopsy procedure to remove a lymph node for laboratory testing. He or she will diagnose classical Hodgkin’s lymphoma if abnormal cells called Reed-Sternberg cells are found within the lymph node.
• Bone marrow test. A bone marrow biopsy and aspiration procedure involves inserting a needle into your hipbone to remove a sample of bone marrow. The sample is analyzed to look for non-Hodgkin’s lymphoma cells to look for non-Hodgkin’s lymphoma cells or to look for non-Hodgkin’s lymphoma cells.  This test is done on numerous types of cancer patients in helping to diagnose the cancer they have.

“Blood cancer is a group of more than 100 cancers that most often begin in the bone marrow and can affect blood cells, lymph nodes, and other parts of the lymphatic system. Blood cancers occur when abnormal blood cells crowd out normal cells, interfering with the ability of normal blood cells to fight infection and reproduce.

Many people discount their symptoms. Exhaustion or random aches and pains are often blamed on stress or age. Night sweats and recurring fevers sometimes get written off as a virus. Lots of itching… must be an allergy. Or a broken bone is usually just seen as just an accident.

They seem like innocent symptoms that can be associated with other common ailments, but any of them could point to blood cancer.

Many people aren’t familiar with blood cancer. In fact, some patients who have been diagnosed with leukemia or lymphoma, myeloma, myelodysplastic syndromes, or myeloproliferative neoplasms, may not realize they have a form of blood cancer.”

Leukemia and Lymphoma Society (https://www.lls.org/blog/defining-and-redefining-blood-cancer-diagnosis)

“Blood Cancer Awareness Month is held every September to raise the profile of blood cancer, which doesn’t get the attention of other cancers. Every year, our blood cancer community comes together to raise awareness.  There are many types of blood cancer. Each have different symptoms, treatments and prognoses.”

Blood Cancer UK (https://bloodcancer.org.uk/about-us/our-campaigns/blood-cancer-awareness-month/)