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Part III Understanding how tuberculosis is spread and controlled in the health care setting.

                                   

How does PTB develop? TB bacilli enters the body and lodges in the lungs (TB Infection). In the lungs, they multiply and slowly eat the cells and the body begins to experience symptoms (TB Disease)  A person who develops a TB disease, when remain untreated, can then begin to infect others. In some cases, the TB germ migrates to other body organs and begin to destroy them, thus the advent of extra-pulmonary (outside) cases of Tuberculosis like TB of the meninges, bones, etc. A TB disease that remains untreated leads to death.

Airborne to prevent the transmission of highly contagious or virulent infections spread by small airborne droplets (smaller than 5 microns) examples know or suspected TB, chicken pox.

Airborne Precautions: spread of microbes on small droplet nuclei through the air ( 5 microns); which transmit 3 feet in air. (ie) TB, Mumps; Pertussis; Influenza; SARS. Private room / or cohort clients, and mask worn if within 3 feet.

TB can be transmitted in just about any setting. It can be spread in places such as homes or worksites. However, TB is most likely to be transmitted in health care settings when health care workers and patients come in contact with persons who have unsuspected TB disease, who are not receiving adequate treatment, and who have not been isolated from others. All health-care settings need an infection-control program designed to ensure the following:

  • Prompt detection of TB disease;
  • Airborne precautions; and
  • Treatment of people who have suspected or confirmed tuberculosis (TB) disease.

Overview of TB Infection-Control Measures

The TB infection-control program should be based on the following three-level hierarchy of control measures:

  1. Administrative controls
  2. Environmental controls
  3. Use of respiratory protective equipment

Administrative Controls

The first and most important level of the hierarchy, administrative controls, are management measures that are intended to reduce the risk or exposure to persons with infectious TB.  These control measures consist of the following activities:

  • Assigning someone the responsibility for TB infection control in the health care setting;
  • Conducting a TB risk assessment of the setting;
  • Developing and implementing a written TB infection-control plan;
  • Ensuring the availability of recommended laboratory processing, testing, and reporting of results;
  • Implementing effective work practices for managing patients who may have TB disease;
  • Ensuring proper cleaning, sterilization, or disinfection of equipment that might be contaminated (e.g., endoscopes);
  • Educating, training, and counseling health care workers, patients, and visitors about TB infection and disease;
  • Testing and evaluating workers who are at risk for exposure to TB disease;
  • Applying epidemiology-based prevention principles, including the use of setting-related TB infection-control data;
  • Using posters and signs to remind patients and staff of proper cough etiquette (covering mouth when coughing) and respiratory hygiene; and
  • Coordinating efforts between local or state health departments and high-risk health-care and congregate settings.

Environmental Controls

The second level of the hierarchy is the use of environmental controls to prevent the spread and reduce the concentration of infectious droplet nuclei.  This includes two types of environmental control.

  • Primary environmental controls consist of controlling the source of infection by using local exhaust ventilation (e.g., hoods, tents, or booths) and diluting and removing contaminated air by using general ventilation.
  • Secondary environmental controls consist of controlling the airflow to prevent contamination of air in areas adjacent to the source airborne infection isolation (AII) rooms; and cleaning the air by using high efficiency particulate air (HEPA) filtration, or ultraviolet germicidal irradiation.

Respiratory Controls

The third level of the hierarchy is the use of respiratory-protection control. It consists of the use of personal protective equipment in situations that pose a high risk of exposure to TB disease.

Use of respiratory protection equipment can further reduce risk for exposure of health care workers to infectious droplet nuclei that have been expelled into the air from a patient with infectious TB disease. The following measures can be taken to reduce the risk for exposure:

  • Implementing a respiratory protection program;
  • Training health care workers on respiratory protection; and
  • Educating patients on respiratory hygiene and the importance of cough etiquette procedures.

Determining the Infectiousness of TB Patients

The infectiousness of a TB patient is directly related to the number of droplet nuclei carrying M. tuberculosis (tubercle bacilli) that are expelled into the air.  The number of tubercle bacilli expelled by a TB patient depends on the following factors:

  • Presence of a cough
  • Cavity in the lung
  • Acid-fast bacilli on sputum smear
  • TB disease of the lungs, airway, or larynx
  • Patient not covering mouth and nose when coughing
  • Not receiving adequate treatment or having prolonged illness
  • Undergoing cough-inducing procedures
  • Positive sputum cultures

Patients can be considered noninfectious when they meet all of the following three criteria:

  • They have three consecutive negative AFB sputum smears collected in 8- to 24-hour intervals (one should be an early morning specimen);
  • They are compliant with an adequate treatment regimen for two weeks or longer; and
  • Their symptoms have improved clinically (for example, they are coughing less and they no longer have a fever).

 

 

QUOTE FOR WEDNESDAY:

“A person with active TB will have symptoms. A person with latent, or inactive, TB will have no symptoms.

You may still have a TB infection, but the bacteria in your body is not yet causing harm. You may experience other symptoms related to the function of a specific organ or system that is affected. Coughing up blood or mucus (sputum) is a sign of in TB of the lungs. Bone pain may mean that the bacteria have invaded your bones.

These symptoms can also occur with other diseases, so it is important to see a healthcare provider and to let them find out if you have TB. If you think you have been exposed to TB, get a TB test.”

American Lung Association (https://www.lung.org/lung-health-diseases/lung-disease-lookup/tuberculosis/symptoms-diagnosis)

Part II Tuberculosis – The symptoms, how its diagnosed and treatment.

Symptoms of active TB include a cough that contains thick, cloudy, and sometimes bloody mucus from the lungs, called sputum, for more than two weeks, tiredness and weight loss, night sweats and a fever, a rapid heartbeat, swelling of the lymph nodes, and shortness of breath and chest pain.

DIAGNOSIS:

There are numerous ways for a doctor to diagnose a patient with tuberculosis. Doctors can typically find latent, or not active, TB by doing a tuberculin skin test, where TB antigens are injected under the skin. If the patient has TB bacteria within their body, a red bump will appear at the injection spot in two days. A blood test can also be performed to detect if a patient has TB. For doctors to discover pulmonary TB, they will often test a sample of mucus from the lungs to see if the TB bacteria are present there. Other tests may include further testing on sputum, or mucus from the lungs, other blood tests, or a chest X-ray to find pulmonary TB. To diagnose extrapulmonary TB, a doctor may take a sample of tissue, or a biopsy, to test as well as a CT scan or an MRI to get a clear visual of the inside of the patient’s body.

TREATMENT:

In the majority of cases, doctors will combine four antibiotics to treat active TB, and it is essential for patients to take this medicine for a minimum of six months.

RIPE regimen
A six-month regimen that includes rifapentine, isoniazid, pyrazinamide, and ethambutol.

A majority of patients are cured of the TB bacteria if they take all the required medicine necessary to destroy the infection. If tests performed by a doctor reveal active TB is still present in the body after six months, treatment will continue for another two or three months. In the worst case scenario, if the TB bacteria is still resistant to multiple antibiotics, called multidrug-resistant TB, treatment will be necessary for one year or longer. Patients with latent TB may be treated with one antibiotic they consume daily for nine months or with a combination of antibiotics taken once a week for twelve weeks. Ensuring every dose is taken reduces the risk of a patient with latent TB to develop active TB.

Patients should be aware that if they miss a dose of their medication or if they stop taking it too soon, the treatment may fail or have to continue for an extensive period. Some patients may even have to start their treatment all over again. This can result in the infection becoming worse or even lead to an infection resistant to antibiotics, which is much more difficult to treat.

There is no guaranteed way for an individual to prevent TB from happening to them or a loved one, but there are some helpful tips individuals can implement if they are at risk or around someone with active TB. As previously stated, latent TB is not contagious and extrapulmonary TB is much more challenging to spread compared to active pulmonary TB. One thing everybody can do to stop the spread of this infection is to get vaccinated, whether as a child or as an adult.

Individuals who are at risk of developing TB or who work with patients who have active TB should always wash and sanitize their hands after they have come into contact with the patient. If an individual is visiting a loved one with TB or taking care of a patient, due to the airborne nature of this infection, uninfected individuals should also keep a healthy distance and wear a mask to prevent them from coming into contact with TB bacteria. Patients who have severe TB should also be quarantined for a time to reduce the risk of spreading the disease as well.

Despite the stigma surrounding this curable disease, with the proper treatment and a bit of patience, individuals infected with tuberculosis can get onto the road to recovery and be healthy sooner rather than later!

Despite the stigma surrounding this curable disease, with the proper treatment and a bit of patience, individuals infected with tuberculosis can get onto the road to recovery and be healthy sooner rather than later!

QUOTE FOR TUESDAY:

“A total of 1.3 million people died from TB in 2022 (including 167 000 people with HIV). Worldwide, TB is the second leading infectious killer after COVID-19 (above HIV and AIDS).

In 2022, an estimated 10.6 million people fell ill with tuberculosis (TB) worldwide, including 5.8 million men, 3.5 million women and 1.3 million children. TB is present in all countries and age groups. TB is curable and preventable.

Multidrug-resistant TB (MDR-TB) remains a public health crisis and a health security threat. Only about 2 in 5 people with drug resistant TB accessed treatment in 2022.”

World Health Organization – WHO  (https://www.who.int/news-room/fact-sheets/detail/tuberculosis)

Part I Tuberculosis What it is and risk factors that prone you in getting TB.

  TB commonly affects lungs.

 

Spreads via coughing and talking near someone so in active TB the patient is put in droplet isolation.  A restricted room and anyone who visits the pt in the room wears a mask.

Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. Tuberculosis generally affects the lungs, but can also affect other parts of the body.

Approximately 8.6 million individuals are diagnosed with tuberculosis (TB), and 1.3 million will die of the disease globally, but it is commonly found in the developing world. TB is a highly contagious but treatable infection that predominantly affects the lungs and throat, but can also spread to the kidney, bones, and brain. So what is tuberculosis exactly? Find out what causes this highly contagious infection, who is most at risk for developing it, and how to treat the different kinds and prevent the spreading of this old world disease.

Tuberculosis, commonly abbreviated to TB, is an infection caused by slow-growing bacteria that festers in areas of the body containing an abundant amount of blood and oxygen, hence why it is commonly found in the lungs. TB found in the lungs is known as pulmonary TB and tuberculosis that spreads to other organs is called extrapulmonary TB. TB is highly contagious, but treatment is often effective and can take between six to nine months to treat, or in severe cases, can take up to two years to treat an infected patient. TB can also be either latent or active. Latent TB is when the immune system is defending the body against TB bacteria and keeping it from becoming active, with no visible symptoms. Active TB is when the TB bacteria are growing inside of the body and symptoms have become noticeable in the patient, and it is easy to spread the disease to others= CONTAGIOUS.

Pulmonary TB is contagious, however extrapulmonary TB does not spread as easily as it is usually contained within another part of the body. TB spreads when an individual has active TB breathes out air that has the TB bacteria in it and another individual breathes in the bacteria from the air. Even more bacteria can become airborne when an infected person coughs or laughs as well.

RISK FACTORS IN DEVELOPING TUBERCULOSIS:

1-Those at risk of developing TB are individuals who have HIV or another illness that weakens the immune system, individuals who have close contact with a patient with active TB such as living in the same house as an infected patient, and those caring for a patient with active TB, such as doctors and nurses.

2-Other risk factors include individuals who live or work in crowded places such as prisons, nursing homes, homeless shelters or wherever individuals may have active TB, as well as individuals who abuse drugs and alcohol.

3- Individuals with poor access to health care, where it is commonly seen in the developing world, as well as homeless individuals and migrant farm workers.

4-As well, traveling to places where untreated TB is common puts an individual at risk, such as Latin America, Africa, Asia, Eastern Europe, and Russia. It is important to note individuals who are at a high risk for developing TB should get tested once or twice a year.

5-As well, traveling to places where untreated TB is common puts an individual at risk, such as Latin America, Africa, Asia, Eastern Europe, and Russia. It is important to note individuals who are at a high risk for developing TB should get tested once or twice a year.  So people who make it in the United States via customs with this disease or left here to another country picking up TB bringing it in America passing customs put many at risk and pick up the TB and continue spreading it till treated and healed.  Just like the others who pick it up in or out of America but spread it in the U.S.  There needs to be closer checking on visitors coming in or citizens that leave home and come back in America to be checked for TB.  This will help decrease the amount of people in America with TB by getting diagnosed immediately with treatment.

 

 

QUOTE FOR MONDAY:

“According to the Centers for Disease Control and Prevention, Health Literacy is the degree to which an individual has the capacity to obtain, communicate, process, and understand basic health information and services to make appropriate health decisions.

Health literacy is important for everyone because, at some point in our lives, we all need to be able to find, understand, and use health information and services.

Studies consistently show that a significant number of people have problems reading, understanding, and acting on health information.

This is an issue because health information is complex and can be hard to understand, and health providers are not necessarily skilled communicators. When organizations or people create and give others health information that is too difficult for them to understand, or we expect them to figure out health services with many unfamiliar, confusing or even conflicting steps, a health literacy problem is created.

Patients also bring a wide range of learning needs to the healthcare experience.

Basic literacy skills, language, age, disability, cultural context, and emotional responses can all affect the way people receive and process information — and the way people process information, in turn, has a direct impact on health outcomes and cost.”

District Health Department (https://www.dhd10.org/healthy-literacy-month/)

QUOTE FOR THE WEEKEND:

“Domestic Violence Awareness Month (DVAM) is a national campaign dedicated to raising awareness about domestic violence. Every October, organizations and individuals unite across the country for a national effort to uplift the needs, voices, and experiences of survivors. Congress declared the month of October to be Domestic Violence Awareness Month in 1989.”

Domestic Violence Awareness Project (https://www.dvawareness.org/HealHoldCenter)

 

QUOTE FOR FRIDAY:

“During hip replacement, a surgeon removes the damaged sections of the hip joint and replaces them with parts usually constructed of metal, ceramic and very hard plastic. This artificial joint (prosthesis) helps reduce pain and improve function.

Also called total hip arthroplasty, hip replacement surgery might be an option if hip pain interferes with daily activities and nonsurgical treatments haven’t helped or are no longer effective. Arthritis damage is the most common reason to need hip replacement.”

MAYO CLINIC (https://www.mayoclinic.org/tests-procedures/hip-replacement/about/pac-20385042)

Types of Hip surgeries & know the components involved.

 

To understand hip replacement, you need to understand the structure of the hip joint, a ball-and-socket joint. The ball, at the top of the femur (thighbone) is called the femoral head. The socket, called the acetabulum, is a part of the pelvis. The ball rotates in the socket, allowing the leg to move forward, backward, and sideways.

Regarding the surgery its repairing the hip to do fixation like it use to without pain.  Fixation is simply the action of making something firm or stable.  Hopkins Medicine states in a hip surgical procedure ORIF (open reduction internal fixation),  for example, is a surgery used to treat a broken thigh bone. … In a “broken hip,” it is actually part of your femur that breaks, and not part of the hipbone itself. … Most people do very well after ORIF for their femur fracture. … you sleep through the operation, so that you won’t feel any pain or discomfort …

In a healthy hip, soft tissue called cartilage covers the ball and the socket to help them glide together smoothly. If this cartilage wears down or gets damaged, the bones scrape together and become rough. This causes pain and can make it difficult to walk.  Think of a car, our brake pads allow our car not to walk but drive, the pads (like cartilage) when thinning down to the point hitting metal (not bone) will scrape on the rotors and don’t repair like the cartilage gone hitting bone to bone the damage to the car will scrape on the rotors till they break and new rotors with brake pads needed.  Where in patient hitting bone to bone, pain results, limitation of the movement takes place at that area (example Hip) and become immobile.  Repair it with surgery and mobilization reoccurs so you can move around like you use to and do regular of activities you previously did.

TYPES OF HIP SURGERY:

The most common type of hip replacement surgery is called a total hip replacement (THR). In this surgery, worn-out or damaged sections of the hip are replaced with artificial implants. The socket is replaced with durable plastic or polyethylene cup with or without a metal titanium shell. The femoral head is removed and replaced with a ball made from ceramic or a metal alloy. The new ball is attached to a metal stem that is inserted into the top of the femur.

Information hip replacements is more easily available than ever before. But direct-to-consumer advertising, online articles and other reports in the media may make it more difficult for people considering these surgeries to understand their options. Becoming familiar with the key considerations that go into selection of the implant that is used to replace the injured or damaged joint can make the process easier.

Total hip replacement surgery – in which the damaged joint is replaced with an implant – is associated with a high degree of successful and predictable outcomes.

Orthopedic surgeons may approach the surgery in one of three different ways:

  • the direct anterior approach in which the incision is made on the front of the hip; this approach may be less disruptive to the muscles and soft tissues surrounding the hip joint, however, surgeons who employ this approach usually use a custom operating table and fluoroscopy (a type of X-ray) to guide placement of the implant during surgery; fluoroscopy is not routinely used with the other two surgical approaches
  • the anterolateral approach in which the incision is made on the side of the hip, toward the front of the body
  • the posterolateral approach in which the incision is made on the side of the hip toward the back of the body

The majority of people who undergo hip replacement receive a traditional hip arthroplasty in which the surgeon uses a stemmed device and prosthetic head to replace the upper part of the femur (the head and neck of the bone) and a hemispherical shaped cup to replace the acetabulum. [Figure A, below]

However, some patients may be candidates for hip resurfacing in which the head and neck of the femur are not removed. In this procedure, the surgeon resurfaces or sculpts the femoral head to accept a metal cap with a short stem. Hip resurfacing is usually most successful in male patients under the age of 55, who are larger in stature There is little data to support functional benefit of one type of hip replacement over the other, although if revision surgery is needed, this may be easier after hip resurfacing.

Illustrations and X-ray imaging of a tradtional hip replaement implant at left and a hip resurfacing implant at right.
Figure A: Illustrations and X-ray images of a traditional hip replacement versus a hip resurfacing implant (Hip resurfacing images courtesy of Smith and Nephew)

It should be noted that while the procedure has vastly improved the ability to treat certain hip disorders with minimal surgical trauma, it is not always an appropriate replacement for other larger operations. If the hip has severe degeneration, total hip replacement may be the only procedure that will provide long-term pain relief. Conversely, in younger patients with skeletal deformities ( i.e. dysplasia, impingement) hip arthroscopy will usually provide relief. But the relief may be short-lived because the underlying pathologic condition has not been corrected.

Total Hip Replacement – Total hip replacement is extremely effective at relieving pain and restoring function as well as range of motion. But, it is an artificial joint and should be performed only if other “joint saving” procedures are not appropriate.

Other forms of orthopedic surgery for the hip are:

Osteotomy – Osteotomy (cutting the bone) is a technique were the anatomy of the femur or socket is altered to relieve pain and prolong survival of the joint by reducing the abnormal loads on the cartilage.

Fusion – Fusion (arthrodesis) makes the hip permanently stiff by obliterated the joint via bone bridging across the joint. This procedure was performed much more frequently in the past and is still appropriate in certain conditions, such as severe arthritis of one hip in a young person.

Arthrotomy – Arthrotomy (opening the joint) is a procedure where the joint is opened to clean out bone spurs, loose bodies, tumors, or to repair fractures.

Know your components involved in the hip surgery:

Dr Padgett is a M.D. from 1987 a resident in orthopedic surgery at Hospital for Special Surgery (HSS) to chief of the Hip Service, and in 2008 to the present chief of the Adult Reconstruction and Joint Replacement Service at HSS.  Learn much more about him in tomorrow’s topic with an excellent hospital to go to if you need this in N.Y.C.   If not you can also find out where to go for help in finding excellent hospitals in hip surgery out on NY to California.

Knowing your components is very helpful.  Hip implants come in two primary types: the traditional single-piece implants and modular models, in which the stem and head of the implant portion that is placed in the femur can be matched independently. Although the single piece implants provide a good fit for many patients, “modular devices were developed to improve the fit of the implant to the patient’s specific anatomy,” explains Dr. Padgett.   However, he adds, some modular implants have recently been found to be associated with problems related to the linkage between the various parts.

Some degree of corrosion and fretting has been seen with these metal on metal components, a process that can result in the creation of metallic debris that is destructive to the soft tissue surrounding the joint. As a result, some of these implants have been recalled.

Implants may be made of a variety of materials including metal (usually titanium), ceramic or polyethylene (a type of hard plastic). Ongoing research and enabling technology will determine new directions in materials used in hip replacement surgery. At present, bearing surfaces – where the femoral component of the implant meets the acetabulum – may combine in three different ways:

  • Metal or ceramic on polyethylene, in which the metal or ceramic head meets a medical-grade polyethylene socket or acetabulum in the pelvis. This combination is now generally regarded to be the “gold standard” for hip replacement. The polyethylene components currently in use are significantly more wear-resistant and resistant to degradation than earlier generations of these plastics.
  • Metal-on-metal, in which a large metal ball at the top of the femur articulates with a metal socket or acetabulum in the pelvis. This combination was originally developed to offer the benefits of increased stability – related to the size of the head – and the ability to create a very thin, but durable metal shell. Owing to the creation of metal fragments or metallic debris that is destructive to the soft tissue surrounding the joint, use of some of these total hip replacement implants has been discontinued in the United States. Metal-on-metal bearing surfaces continue to be used for hip resurfacing.
  • Ceramic on ceramic, in which both components are made of the same material; this combination has been shown to have good durability, but there is a risk of the ceramic breaking and ceramic on ceramic hips can produce an audible squeak.

Placement of the hip implant components involves an additional consideration: how the implants are bonded to the bones. This can be accomplished either through the use of acrylic cement or with uncemented fixation, in which the surface of the implant is composed of a porous, honeycomb-like surface that allows for the in-growth of new bone tissue to help hold the component in place.

“On the cup portion of the implant, uncemented fixation is clearly superior,” Dr. Padgett a orthopedic M.D. and from 2008  says. “However, cemented fixation may be preferable in older patients or others with compromised bone quality.” With regard to fixation of the stem, Dr. Padgett notes, available data shows no advantage of one type of fixation over the other, and the decision to use one over the other is left to the surgeon’s discretion.

With a history of excellent surgical technique and outcomes, the focus of new development in this area is on the use of enabling technology to improve preparation and component positioning in hip and knee replacement surgery. These tools include navigation devices that provide three-dimensional spatial orientation and robotics which can also provide tactile feedback during surgery. “The role of these emerging technologies is still evolving,” Dr. Padgett notes.

Much of the important early work in the development of successful hip implants took place in the late 1960s and early 1970s, including that of British surgeon John Charnley, MD and introduced at HSS by Philip D. Wilson, Jr. MD.

 

 

 

 

QUOTE FOR THURSDAY:

“October was first designated as National Down Syndrome Awareness Month in the 1980s and has been recognized every October since. It is a time to celebrate people with Down syndrome and make others aware of their abilities and accomplishments.

People with Down syndrome are just like everyone else. They have similar dreams and goals, and they want to have successful careers and families. They can drive, go to work, go to college, go on dates, get married, and contribute to society.”

Special Oympics (ttps://www.specialolympics.org/stories/news/national-down-syndrome-awareness-month#:~:text=October was first designated as,are just like everyone else.)