“Every year, there are an estimated 20 MILLION new STD infections in the U.S.  There are steps you can take to prevent them!”

Columbia Presbyterian (wwwcolumbiadoctors.org)

“Myasthenia gravis (my-us-THEE-nee-uh GRAY-vis) is characterized by weakness and rapid fatigue of any of the muscles under your voluntary control. Myasthenia gravis is caused by a breakdown in the normal communication between nerves and muscles.”

MAYO CLINIC

“Prostate cancer is the most common cancer among men, excluding skin cancer.  African-American men are at the greatest risk to develop prostate cancer. ”

John Hopkins Hospital

Normal Prostate                            vs.   Benign Prostatic Hyperplasia

The prostate is a walnut-shaped gland that is part of the male reproductive system. The main function of the prostate is to make a fluid that goes into semen. Prostate fluid is essential for a man’s fertility. The gland surrounds the urethra at the neck of the bladder. The bladder neck is the area where the urethra joins the bladder. The bladder and urethra are parts of the lower urinary tract. The prostate has two or more lobes, or sections, enclosed by an outer layer of tissue, and it is in front of the rectum, just below the bladder. The urethra is the tube that carries urine from the bladder to the outside of the body. In men, the urethra also carries semen out through the penis.

What is benign prostatic hyperplasia?

Benign prostatic hyperplasia––also called BPH––is a condition in men in which the prostate gland is enlarged and not cancerous. Benign prostatic hyperplasia is also called benign prostatic hypertrophy or benign prostatic obstruction.

The prostate goes through two main growth periods as a man ages. The first occurs early in puberty, when the prostate doubles in size. The second phase of growth begins around age 25 and continues during most of a man’s life. Benign prostatic hyperplasia often occurs with the second growth phase.

As the prostate enlarges, the gland presses against and pinches the urethra. The bladder wall becomes thicker. Eventually, the bladder may weaken and lose the ability to empty completely, leaving some urine in the bladder. The narrowing of the urethra and urinary retention––the inability to empty the bladder completely––cause many of the problems associated with benign prostatic hyperplasia.

Ending line the prostate enlarges pushes up to the superior both front and back aspects of the penis (just below the urinary bladder) narrowing the urethra in the penis shaft (on both sides of the urethra) causing urination difficulty and frequently urinating.  (See figure below  the picture shows in the top part the urinary bladder and the prostate below it Left normal Right BPH).

What causes benign prostatic hyperplasia?

The cause of benign prostatic hyperplasia is not well understood; however, it occurs mainly in older men. Benign prostatic hyperplasia does not develop in men whose testicles were removed before puberty. For this reason, some researchers believe factors related to aging and the testicles may cause benign prostatic hyperplasia.

Throughout their lives, men produce testosterone, a male hormone, and small amounts of estrogen, a female hormone. As men age, the amount of active testosterone in their blood decreases, which leaves a higher proportion of estrogen. Scientific studies have suggested that benign prostatic hyperplasia may occur because the higher proportion of estrogen within the prostate increases the activity of substances that promote prostate cell growth.

Another theory focuses on dihydrotestosterone (DHT), a male hormone that plays a role in prostate development and growth. Some research has indicated that even with a drop in blood testosterone levels, older men continue to produce and accumulate high levels of DHT in the prostate. This accumulation of DHT may encourage prostate cells to continue to grow. Scientists have noted that men who do not produce DHT do not develop benign prostatic hyperplasia.

How common is BPH?

Benign prostatic hyperplasia is the most common prostate problem for men older than age 50. In 2010, as many as 14 million men in the United States had lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Although benign prostatic hyperplasia rarely causes symptoms before age 40, the occurrence and symptoms increase with age. Benign prostatic hyperplasia affects about 50 percent of men between the ages of 51 and 60 and up to 90 percent of men older than 80.

Signs and Symptoms

BPH, the prostate gland grows in size. It may compress the urethra which courses through the center of the prostate. This can impede the flow of urine from the bladder through the urethra to the outside. It can cause urine to back up in the bladder (retention) leading to the need to urinate frequently during the day and night. Other common symptoms include a slow flow of urine, the need to urinate urgently and difficulty starting the urinary stream. More serious problems include urinary tract infections=pain in pelvic region and complete blockage of the urethra, which would be a medical emergency and can lead injury to the kidneys.

Treatment:

Is BPH always treated?

No. Treatment of BPH is usually reserved for men with significant symptoms. Watchful waiting with medical monitoring once a year is appropriate for most men with BPH.

How is BPH treated?

There are several different ways to treat BPH:

Men should carefully weigh the risks and benefits of each of these options. Prostate surgery has traditionally been seen as offering the most benefits for BPH but unfortunately carries the most risks.

• Watchful waiting is often chosen by men who are not bothered by symptoms of BPH. They have no treatment but get regular checkups and wait to see whether or not the condition gets worse.

Medical Treatment through drugs is used by some men rangaing from alpha blockers relax the smooth muscles of the prostate, and the bladder neck.  An example of these meds are  tamzulosin (Flomax),  alfusozin, (Uroxatral), and older medications such as  terazosin (Hytrin), slidosin (Rapaflo) or doxazosin (Cardura).  

Also 5-alpha reductase inhibitors block the conversion of the male hormone testosterone into its active form in the prostate.  Examples of 5-alpha reductase inhibitors include Finasteride (Proscar) and dutasteride (Avodart). Side effects of finasteride may include declining interest in sex, problems getting an erection, and problems with ejaculation.

Surgery or office procedures may also be used to treat BPH, most commonly in men who have not responded satisfactorily to medication or those who have more severe problems, such as a complete inability to urinate.

• Transurethral resection of the prostate (TURP) has been used for the longest period of time. After the patient is given anesthesia, the doctor inserts a special instrument into the urethra through the penis. With the instrument, the doctor then shaves away part of the inner prostate to relieve the outflow of urine from the bladder.
• Laser procedures: A number of laser procedures are available, some of which can be performed in the doctor’s office with minimal anesthesia. These procedures also involve the removal of obstructing prostate tissue. They are generally associated with less bleeding and quicker recovery than TURP.
• Microwave therapy: This procedure is generally performed in the office and involves the use of microwave energy delivered to the prostate to kill some of the cells leading eventually to shrinkage of the prostate.

NIH National Institute of Aging

“Dementia with Lewy bodies (DLB) is a type of progressive dementia that leads to a decline in thinking, reasoning and independent function because of abnormal microscopic deposits that damage brain cells over time.“

Alzheimer’s Association (alz.org)

“We don’t have stems and we don’t flower, but our body parts, like those of plants, are controlled by circadian clocks,”. Clocks operate more or less the same way in all organisms, but some aspects of clock function are easier to study in plants.

Laurie Tompkins-NIH geneticist, (National Institute of General Medicine Sciences).

Look at medical proof, in July 2011 by online publication of Nature, investigated why Arabidopsis does its major stem-growing in the dark—a pattern common to most plants.

Biologist Steve Kay and colleagues at the University of California, San Diego, report that a specific trio of proteins regulates the rhythm in Arabidopsis stems.  Arabidopsis thaliana helped scientists not very long ago too unearth new clues about the daily cycles of many organisms, including humans. This is the latest in a long line of research, much of it supported by the National Institutes of Health, that uses plants to solve puzzles in human health.  While other model organisms may seem to have more in common with us, greens like Arabidopsis provide an important view into genetics, cell division and especially light sensing, which drives 24-hour behavioral cycles called circadian rhythms.

Some human cells, including cancer cells, divide with a 24-hour rhythm. One of the main human circadian rhythm genes, cryptochrome, has been associated with diabetes and depression. Both of these discoveries grew from work with plants.

The Arabidopsis Thaliana Plant

T group of proteins, called the evening complex, interacts in the early evening to silence two genes that usually promote plant growth. When the evening complex’s activity trails off a few hours before dawn, proteins release the brakes on growth and plants enter their nightly phase of rapid stem elongation.

When Kay’s team mutated the three genes that code for the evening complex, they noticed that this made the Arabidopsis biological clock run out of sync—stems grew unusually long and flowered early.

Scientists aren’t yet certain why night is the best time for stems to grow, but Kay speculates it has to do with using resources efficiently. Plants pick up carbon and nitrogen during the day, then store these essential nutrients as starch and proteins. “In the later night, they can release these resources in a coordinated fashion to provide the building blocks for stem growth,” says Kay.  “

Our understanding of human health and the role of clocks in health and disease can greatly benefit from studying how clocks work in plants,” he adds.

Scientists like Kay are interested in answering basic biological questions, but others who work with plants have their eyes on future disease therapies. Plant-based molecules, for instance, are being used to target reservoirs of HIV that hide out in their hosts. At the University of California, Berkeley, chemist Jay Keasling is looking for simple ways to get microbes to produce greater quantities of these plant-based molecules at lower cost.

How plants like Arabidopsis suppress harmful genes may also help improve HIV therapies. A team of biologists led by Craig Pikaard at Washington University in St. Louis is investigating RNA polymerases, chemicals important in determining which genes get switched on, to learn how plants silence harmful virus-derived genes. Similar silencing pathways could be harnessed for HIV therapies.

More generally, scientists are looking toward plants as a medicinal source. Chemist Sarah O’Connor at MIT is genetically engineering periwinkle plants, the natural source of the anticancer drug vinblastine, to produce variations of the drug with halogens attached. Halogens make some medicines last longer in the body, meaning that probing periwinkle’s capabilities could make cancer treatments more effective.

Plant compounds present in carrots and parsley may one day support more effective delivery of chemotherapy treatments, new research has found. Specific plant compounds are able to inhibit transport mechanisms in the body that select what compounds are absorbed into the body, and eventually into cells. These same transport mechanisms are known to interfere with cancer chemotherapy treatment.

Some further examples of good compounds coming from plants for human lives are:

Flavonoids are one class of secondary plant metabolites that are also known as Vitamin P or citrin. These metabolites are mostly used in plants to produce yellow and other pigments which play a big role in coloring the plants. In addition, Flavonoids are readily ingested by humans and they seem to display important anti-inflammatory, anti-allergic and anti-cancer activities. Flavonoids are also found to be powerful anti-oxidants and researchers are looking into their ability to prevent cancer and cardiovascular diseases. Flavonoids help prevent cancer by inducing certain mechanisms that may help to kill cancer cells, and researches believe that when the body processes extra flavonoid compounds, it triggers specific enzymes that fight carcinogens. Good dietary sources of Flavonoids are all citrus fruits, which contain the specific flavanoids hesperidins, quercitrin, rutin, berries, tea, dark chocolate and red wine that includes many of the health benefits attributed to these foods come from the Flavonoids they contain.

Phytic acid is the main method of phosphorus storage in plant seeds, but is not readily absorbed by many animals (only absorbed by ruminant animals). Not only is phytic acid a phosphorus storage unit, but it also is a source of energy and cations, a natural antioxidant for plants, and can be a source of mycoinositol which is one of the preliminary pieces for cell walls.

Phytic acid is also known to bond with many different minerals, and by doing so prevents those minerals from being absorbed; making phytic acid an anti-nutrient. There is a lot of concern with phytic acids in nuts and seeds because of its anti-nutrient characteristics. In preparing foods with high phytic acid concentrations, it is recommended they be soaked in after being ground to increase the surface area. Soaking allows the seed to undergo germination which increases the availability of vitamins and nutrient, while reducing phytic acid and protease inhibitors ultimately increasing the nutritional value. Cooking can also reduce the amount of phytic acid in food but soaking is much more effective.

Phytic acid is an antioxidant found in plant cells that most likely serves the purpose of preservation. This preservation is removed when soaked, reducing the phytic acid and allowing the germination and growth of the seed.

Atropine is a type of secondary metabolite called a tropane alkaloid.

Alkaloids contain nitrogens, frequently in a ring structure, and are derived from amino acids. Tropane is an organic compound containing nitrogen and it is from tropane that atropine is derived from. Atropine is synthesized by a reaction between tropine and tropate, catalyzed by atropinase. Within Atropa belladonna atropine synthesis has been found to take place primarily in the root of the plant. The concentration of synthetic sites within the plant is indicative of the nature of secondary metabolites.

Gossypol has a yellow pigment and is found in cotton plants. It occurs mainly in the root and/or seeds of different species of cotton plants.  Gossypol can have various chemical structures. It can exist in three forms: gossypol, gossypol acetic acid, and gossypol formic acid. All of these forms have very similar biological properties. Gossypol is a type of aldehyde, meaning that it has a formyl group. The formation of gossypol occurs through an isoprenoid pathway. Isoprenoid pathways are common among secondary metabolites.  3Gossypol’s main function in the cotton plant is to act as an enzyme inhibitor. An example of gossypol’s enzyme inhibition is its ability to inhibit nicotinamide adenine dinucleotide-linked enzymes of Trypanosoma cruzi. Trypanosoma cruzi is a parasite which causes Chaga’s disease.

For some time it was believed that gossypol was merely a waste product produced during the processing of cottonseed products. Extensive studies have shown that gossypol has other functions. Many of the more popular studies on gossypol discuss how it can act as a male contraceptive. Gossypol has also been linked to causing hypokalemic paralysis. Hypokalemic paralysis is a disease characterized by muscle weakness or paralysis with a matching fall in potassium levels in the blood. Hypokalemic paralysis associated with gossypol in-take usually occurs in March, when vegetables are in short supply, and in September, when people are sweating a lot. This side effect of gossypol in-take is very rare however. Gossypol induced hypokalemic paralysis is easily treatable with potassium repletion.

Believe or not, plants enhanced our lives.

Remembering all of those who gave the ultimate sacrifice.