The Facts About Stevens-Johnson Syndrome (SJS/TEN) as of 2023 through Stevens-Johnson Syndrome Foundation state the following:

“FIRST What is this condition SJS – Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe adverse reactions to medication and, in some instances, viruses and mycoplasma pneumonia.

According to the FDA, adverse drug reactions (ADRs) account for 2,216,000 hospitalizations each year that result in injury or death.

SJS is one of the most debilitating ADR’s recognized. It was first discovered in 1922 by pediatricians Albert Stevens and Frank Johnson after diagnosing two children with severe ocular and oral involvement due to drug reactions

The Signs and Symptoms of SJS or TEN:

Recognition of the early symptoms of SJS and prompt medical attention are the most invaluable tools in minimizing the possible long-term effects of SJS.

-Rash, blisters or red splotches on skin
-Persistent fever
-Blisters in mouth, eyes, ears, nose or genital area
-Swelling of eyelids, red eyes, Conjuctivitis
-Flu-like symptoms

*Have recently taken a prescription or over-the counter (OTC) medication
Target lesions are not always seen in SJS/TEN!

IF YOU NOTICE TWO OR MORE OF THESE SYMPTOMS,
CONTACT A PHYSICIAN IMMEDIATELY!

Treatments for SJS/TEN:

The offending drug must be stopped immediately to prevent
complications.

Supportive care.

IV fluids and high-calorie formulas are given to promote
healing.

Antibiotics are given when necessary to prevent secondary
infections.

Pain medications are given for comfort.

Most SJS patients are treated in ICU, but TEN patients
should be treated in a burn unit.

Treatments can include the following medications:
-pulse steroids,
-Immunoglobulin (IVIG),
and Cyclosporine therapies.

The doctors to see for this condition:

Dermatologists, ophthalmologists and infectious disease doctors should be consulted.

If ocular involvement occurs, amniotic membrane grafts in the first 3 to 5 days of diagnosis may prevent serious eye damage

Side Effects from SJS/TEN patients:

-Blindness or Visual impairment
-Photophobia
-Dry eye syndrome
-Lung damage including Asthma
and Chronic Obstructive Pulmonary Disease (COPD)
-Permanent loss of nail beds
-Scarring and hyperpigmentation
-Alopecia
-Arthritis
-Chronic fatigue

These are some of the side effects reported to the Stevens Johnson Syndrome Foundation through their SJS registry fact sheet in 2023.

** Almost any DRUG can cause SJS/TEN, including over-the-counter drugs. SJS and TEN do not discriminate against anyone! Everyone should be aware of adverse drug reactions.